With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73286-71-2,N-Boc-2-pyrroline,as a common compound, the synthetic route is as follows.,73286-71-2
tert-butyl-(3-trimethylsilylethynyl)-3a,4, 5,6a-tetrahydropyrrolo[3,2-d]isoxazole-6-carboxylate (Intermediate 20b, alternative procedure) A solution of tert-butyl 2,3-dihydropyrrole-1-carboxylate (500 mg, 2.95 mmol) and 3-trimethylsilylprop-2-ynal oxime (459.06 mg, 3.25 mmol) in MTBE (15 mL) was cooled to 0-5 C. while stirring. Sodium hypochlorite (2.806 mL, 5.91 mmol) was added dropwise keeping the reaction temperature below 20 C. The reaction mixture was stirred at the same temperature for 3 hours; afterwards, it was quenched with Na2SO3 solution; the two phases were separated, the organic layer was washed with water and brine, dried over Na2SO4, filtered and evaporated to dryness in vacuo. The crude residue was purified by automated flash chromatography (Biotage SP1, cartridge type SNAP25) using a gradient from petroleum ether:EtOAc 95:5 to 7:3.
As the paragraph descriping shows that 73286-71-2 is playing an increasingly important role.
Reference£º
Patent; Recordati Ireland Ltd.; Riva, Carlo; De Toma, Carlo; Angelico, Patrizia; Poggesi, Elena; Graziani, Davide; (36 pag.)US2016/185798; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem