1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 2.5 g of 3,4-dibromo-1H-pyffole-2,5-dione (10 mmol) and 1 g of NMM in 60 mL of THF, MeOCOC1 (10 mmol, 940 mg in 10 ml DCM) was added dropwise, stuffed for 20 mm, then the reaction solution was diluted with 6o mL of DCM, washed 3 time by water, the organic phase was stirred by sodium sulfate anhydrous, concentrated, 2.65g of methyl 3,4-dibromo-2,5-dioxo-2H-pyrrole-1(5H)-carboxylate was obtained. To 311mg, 1 mmol of this compound, 2-(2-azidoethoxy)ethanamine (130 mg, 1 mmol) and 5 mL DCM was added, TLC shown the reaction finished in 20 mm, then extracted by DCM and brine, washed by NH4C1 solution, dried on sodium sulfate anhydrous, and then concentrated for column purification, flashed by 2:1 hexane and ethyl ethylate, 230 mg of 1-(2-(2-azidoethoxy)ethyl)-3,4-dibromo-1H-pyffole-2,5-dione obtained. 1HNMR: 3.32 ppm (t, J = 5.0 Hz, 1H), 3.40 ppm (t, J = 5.0Hz, 1H), 3.50 ppm (q, J =5.0 Hz, 1H), 3.62 ppm (t, J = 5.0 Hz, 1H), 3.63-3.69 ppm (m, 3H),3.84 ppm (t, J = 5 hz, 1H). Fw: 365.9, C8H8Br2N4O3 Mass Peaks (1:2:1): 366.9, 368.9,370.9.
1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SORRENTO THERAPEUTICS, INC.; FU, Yanwen; KAUFMANN, Gunnar, F.; JONES, Bryan; TOUGHIRI, Raheleh; (82 pag.)WO2015/175357; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem