Month: September 2020

6913-92-4, 1-Benzyl-3-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6913-92-4, a 5-benzyl-3-(tetrahydropyran-2-yloxymethyl)-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole To a solution of 1-benzyl-2,5-dihydro-1H-pyrrole (13.5 g, 84.8 mmol) in benzene (150 mL) was added 2-(2-nitroethoxy)tetrahydropyran (37 g, 211.2 mmol) and triethylamine (5.4 mL, 38.4 mmol). The solution was heated to reflux and phenyl isocyanate (37.8 mL, 347.8 mmol) was slowly added over 2 hours. After the addition was complete, the mixture was refluxed overnight and the resulting precipitate removed by filtration. The filtrate was concentrated in vacuo and the residue purified by column chromatography eluding with ethyl acetate:hexanes (1:4), to obtain 19.5 g the title compound. 1H NMR (200 MHz, CDCl3) delta 7.38-7.18 (m, 5H), 5.10-4.98 (m, 1H), 4.68-4.58 (bs, 1H), 4.50-4.18 (m, 2H), 3.86-3.42 (m, 5H), 3.25-3.05 (m, 2H), 2.44-2.24 (rA, 2H), 1.82-1.38 (m, 6H).

6913-92-4 1-Benzyl-3-pyrroline 561506, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Ellsworth, Edmund Lee; Kerschen, James Alan; Powell, Sharon Anne; Sanchez, Joseph Peter; Showalter, Howard Daniel Hollis; Stier, Michael Andrew; Tran, Tuan Phong; US2003/114666; (2003); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 17 Preparation of 3,4-Diiodo-pyrrole-2,5-dione To dibromomaleimide (500.0 mg, 2.0 mmol) in acetic acid (50 ml) was added sodium iodide (886.5 mg, 5.9 mmol). The reaction mixture was heated to 120 C. and refluxed for 2 h. The reaction was allowed to cool down to RT, H2O (50 ml) was added and kept at 4 C. for 15 h. The yellow precipitate was filtered off and air dried to afford the desired compound as an orange crystalline powder (415 mg, 60%). 1H NMR (500 MHz, MeOD): no signals; 13C NMR (125 MHz, MeOD): delta=169.3 (C), 119.5 (C); IR (solid, cm-1): 3244 (s), 2944 (m), 2833 (m); MS (EI) m/z, (%): 349 (M, 83), 179 (100); Mass calc. for C4H12O2N: 348.80912. Found: 348.81026. m.p. 238-241 C. (Literature: 254-255 C.).

1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCL Business Plc; Smith, Mark; Caddick, Stephen; Baker, James; Chudasama, Vijay; (80 pag.)US9295729; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

57079-01-3,57079-01-3, 11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A two-neck, 500 mL flask was charged with 26.24 g (0.1 mole) pentacyclopentadecane dimethanol, 9.04 g (0.105 mole) methacrylic acid, 29.54 g (0.105 mole) maleimidoundecanoic acid, 150 mL toluene, 2.0 g methanesulfonic acid, and 60 mg hydroquinone. A magnetic stir bar was placed in the flask and a gas inlet tube, Dean-Stark trap and condenser were attached. The mix was refluxed under an air sparge for 3.5 hours and 3.7 mL water (3.6 mL theoretical yield) was collected in the trap. The mixture was cooled to room temperature and neutralized with a mix of 15 g sodium bicarbonate and 5 mL water. The mix was dried with 12 g anhydrous magnesium sulfate and then passed over 20 g of silica gel. The bulk of the toluene was removed under vacuum on a rotary evaporator. The last trace of solvent was removed using an air sparge. The final product was a viscous, clear, red liquid that had a 40 C. viscosity of 3,028 centipoise. The product weighed 55.12 g (92.8% of theoretical yield). Thermogravimetric analysis (TGA) was performed on the compound (ramp rate of 10 C. per minute in air) and the retained weight was 100.0% and 99.9% at 200 C. and 300 C., respectively. The decomposition onset was 432.8 C. An FTIR was run on this compound and significant absorptions were found at 2925, 1714, 1638, 1407, 1172, 827, and 695 wavenumbers.

57079-01-3 11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid 4618600, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Designer Molecules, Inc.; US8039663; (2011); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1).

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3

To a solution of maleimide (6.35 g, 65.4 mmol, 1.0 eq. ) in EtOAc (120 mL) were added N-methyl morpholine (8.6 mL, 78.5 mmol, 1.2 eq. ) and methyl chloroformate (6.0 mL, 78.5 mmol, 1.2 eq. ) at 0 . The reaction was stirred at 0 for 30 min and r.t. 1 h. The solid was filtered off and filtrate concentrated. The residue was dissolved in CH2Cl2and filtered through a silica gel plug and eluated with CH2Cl2to remove the color. The appropriate fractions were concentrated and resulted solid was triturated with 10%EtOAc/PE to give a white solid (9.00 g, 89%yield) .

The synthetic route of 541-59-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3, Maleimide is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,541-59-3

The title compound was prepared using a modification of the method of Foley, et al., 2010 Biomol. Chem. 8:4601-4606). To a solution of maleimide (5.0 g, 51.5 mmole) in dry ethyl acetate (250 mL) was added N-methylmorpholine (5.7 mL, 51.5 mmole) and this mixture cooled to 0 C. (ice-bath) under anhydrous N2(g). Methyl chloroformate (4.8 mL, 61.8 mmole) was added slowly with stirring under anhydrous conditions, and the reaction allowed to stir at 0 C. for 30 min. and at room temperature for 30 min. The reaction mixture was filtered through a Buchner funnel and the white precipitate washed with ethyl acetate (100 mL). The combined filtrate was extracted with ice-water (1*100 mL) and brine solution (1*100 mL) and then dried over anhydrous magnesium sulfate. The product was filtered and evaporated to a clear oil that was co-evaporated with dry toluene (2*25 mL) and dried in vacuo under high vacuum overnight. The resulting clear oil was crystallized by trituration from anhydrous diethylether (50 mL) to give an off-white solid (2.77 g, 35%) homogeneous by t.l.c. (irrigant=9:1 dichloromethane:methanol, Rf=0.62).

541-59-3 Maleimide 10935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Marker Gene Technologies, Inc.; Naleway, John Joseph; Harlan, Fiona Karen; Lusk, Jason Scott; (72 pag.)US2018/207287; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1)., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an oven-dried 250 ml round bottom flask of dibromomaleimide (DBM) (1.001 g, 3.93mmol), dry methanol (25.0 mL) was added. The solution was allowed to stir at 40 C under N2 gas. In another flask, an anhydrous solution of trifluoromethylbenzyl mercaptan (3.18 g, 16.57 mmol), TCEP (0.50 g, 1.24 mmol), and sodium acetate (1.31 g, 15.99 mmol) in dry methanol (25.0 mL) was added in 6.25 mL increments to the flask with DBM every 30 minutes under anhydrous conditions at 40 C. The reaction mixture was stirred for 4 hours. The solvents were removed in vacuo. The crude product was dissolved in dichloromethane to vacuum filtrate product of sodium acetate and solution was dried in vacuo. The crude product was purified via column chromatography and dried in vacuo to yield intermediate product (1) as a yellow powder (0.918 g, 1.92 mmol, 49%). Rf data (9:1DCM/hexanes) 0.32; 1H NMR (400 MHz CDCl3) delta data 7.63 (4H, d, CH), 7.56 (4H, d, CH), 4.49 (4H, s, CH); 13CNMR (500 MHz CDCl3) delta data 165.7, 140.7, 136.5, 129.2, 129.2, 129.2, 129.2, 125.7, 35.4; HRMS calcd forC20H12F6NO2S2 (M-) 476.0219, found: 476.0214.

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Letter; Hidalgo, Francisco J.; Lorentz, Nathan A. P.; Luu, Tintin B.; Tran, Jonathan D.; Wickremasinghe, Praveen D.; Martini, Olnita; Iovine, Peter M.; Schellinger, Joan G.; Letters in Organic Chemistry; vol. 17; 2; (2020); p. 85 – 89;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3

Example 1 Preparation of N-Methoxycarbonylmaleimide STR13 To a 1000 ml 3-neck round bottom flask was added 400 ml of ethyl acetate. The flask was placed in an ice bath and the temperature was allowed to drop to about 0 C. To the cooled flask was sequentially added with stirring 7.76 g of maleimide and 8.8 ml of N-methylmorpholine. Then, through an addition funnel was added to the stirring mixture 6.26 ml of methyl chloroformate at a rate so as not to raise the temperature above 3 C. Through the addition funnel was then added 5 ml of ethyl acetate as washing and the washing was added to the reaction mixture. The reaction mixture was stirred for 30 minutes at between 0-3 C. Thereafter, the reaction mixture was filtered through a Buchner funnel. The flask was washed 2* with 10 ml of ethyl acetate and the washings were also filtered. The resulting precipitate was washed 2*with 10 ml of ethyl acetate. The combined filtrate and washings were extracted with 100 ml of ice cold water, dried (10 g Na2 SO4), and evaporated to dryness under reduced pressure.

As the paragraph descriping shows that 541-59-3 is playing an increasingly important role.

Reference£º
Patent; Hybritech Incorporated; US5091542; (1992); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3,541-59-3, Maleimide is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methylchloroformate (4.4 niL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 niL of EtOAc at 0 0C. The suspension was stirred at 0 C for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

As the paragraph descriping shows that 541-59-3 is playing an increasingly important role.

Reference£º
Patent; ENZON PHARMACEUTICALS, INC.; WO2008/34124; (2008); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem