Month: September 2020

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-beta-alanine The title compound was prepared from commercially available (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid by coupling with tert-butyl beta-alaninate hydrochloride (1:1) in the presence of EDCI/HOBt and N,N-diisopropylethylamine and subsequent deprotection with trifluoroacetic acid. LC-MS (Method 1): Rt=0.32 min; MS (ESIpos): m/z=227 (M+H)+.

25021-08-3, As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3,541-59-3, Maleimide is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of maleimide (6.35 g, 65.4 mmol) in ethyl acetate (120 niL) at 0 C was added NMM (8.6 niL, 78.5 mmol), followed by methyl chloroformate (6.0 mL, 78.5 mmol). The reaction was stirred at 0 C for 30 min and r.t. 1 h. The solid was filtered off and filtrate was concentrated. The residue was dissolved in methylene chloride and filtered through a silica gel plug and eluted with methylene chloride to remove the red color. After concentration, the solid was triturated with ethyl acetate and petroleum ether to give a white solid (9.0 g, 88% yield).

541-59-3 Maleimide 10935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO, LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; GAI, Shun; YE, Hangbo; YANG, Chengyu; GUO, Huihui; ZHOU, Xiaomai; XIE, Hongsheng; TONG, Qianqian; CAO, Minjun; ZHAO, Linyao; JIA, Junxiang; LI, Wenjun; ZUO, Xiaotao; LIN, Chen; XU, Yifang; GUO, Zixiang; (274 pag.)WO2017/46658; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1122-10-7, In a 50 mL two-necked flask,A mixture of NaH (30 mg, 0.75 mmol, 60% by mass, dispersed in paraffin) was suspended in 5 mL of DMF, and 5 mL of DMF dissolved in 2,3-dibromomaleimide (127.5 mg, 0.5Mmol) and low temperature reaction for 30 min,(47muL, 0.75mmol), low temperature reaction 30min, dropping saturated NH4Cl solution to terminate the reaction, CH2Cl2 extraction, organic layer evaporated, silica gel column chromatography,Petroleum ether: ethyl acetate = 30: 1 (v / v) to give 92 mg of white crystals (82a) in 69% yield.

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; Ocean University of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; (142 pag.)CN106083830; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

151038-94-7, 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

151038-94-7, Example 8. Preparation of Compound 19 [0281] [0282] The hydrazide-TFA salt of Compound 19-2 (6.4mg, 20 mumol) was added to a mixture of Compound 19-1 (7.7 mg, 10 mumol) in 5 methanol/dichloromethane at 0 . The reaction mixture was warmed to the ambient temperature and stirred for 5h, then concentrated under reduced pressure and purified on a silica gel column eluting with 3 methanol/dichloromethane to give 3.3 mg of Compound 19-3. MS [M+H] +: 973.42.

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD.; YUAN, Jiandong; SONG, Yunsong; HUANG, Yangqing; ZHU, Rui; HU, Xiaowei; FANG, Cheng; WO2015/106599; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2973-17-3,1-Allyl-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

Synthesis Example f-III-4 Synthesis of Silicone Compound: 1 = 1, m = n = 0, X1 = X3 = Substituent A-6 in the Chemical Structure 1 Drip 3.95 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.055 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 3.0 parts of silicone compound: (1,1,3,3,5,5-hexamethyl trisiloxane (manufactured by Sigma-Aldrich Co) and 3.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 4.85 parts of the target silicone compound f-M4. The infra-red absorption spectrum graph is shown as Fig. 8D., 2973-17-3

2973-17-3 1-Allyl-1H-pyrrole-2,5-dione 18098, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3, Maleimide is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

541-59-3, 1) Ethyl-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 9.7 g (0.1 mol) of maleimide are solubilized in 50 ml of ethyl acetate and 1.1 ml of N-methylmorpholine at 5 C. 1.1 ml of ethyl chloroformate are added dropwise. The mixture is stirred for 1/2 hour. The insoluble material is removed by filtration. The filtrate is washed with 50 ml of water. The organic phase is dried over MgSO4 and is then concentrated under vacuum. The oil obtained is purified on Merck Geduran silica gel (40-63 mum). Elution: CH2Cl2/ACOEt 66/34. 16.9 g are isolated with a yield of 50%. Mass spectrum: M/z=170.1 (ES+) theoretical M=169

541-59-3 Maleimide 10935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Guerbet.; US2010/297025; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: In a 100 mL dry one-neck round bottom flask equipped with a magnetic stir bar, 3,4-dibromomaleimide (1.00 equiv) was added under N2 atmosphere. Acetone (0.62 M) and K2CO3 (1.10 equiv) were successively added and vigorously stirred for 10 min. Then, the corresponding alkylating reagent (1.20-1.40 equiv) was added to one portion. The reaction was stirred during the overnight period and quenched by solvent evaporation and extraction with AcOEt (3 x 20 mL). The crude sample from the reaction was purified by column chromatography. The spectroscopic data match perfectly with those previously described.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Mendoza-Macias, Claudia Leticia; Solorio-Alvarado, Cesar Rogelio; Alonso-Castro, Angel Josabad; Alba-Betancourt, Clara; Deveze-Alvarez, Martha Alicia; Padilla-Vaca, Felipe; Reyes-Gualito, Arturo; Chemical Papers; vol. 74; 5; (2020); p. 1429 – 1438;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of the free thiol, Dl (88 mg, 0.105 mmol) and l-((2,5- dioxopyrrolidin-l-yl)oxy)-l-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid (sulfo- SPDB) (64.0 mg, 0.158 mmol) in anhydrous dichloromethane (2.10 mL) was added DIPEA (55.0 mu, 0.315 mmol) under nitrogen at room temperature. The mixture stirred for 16 hours and then l-(2-aminoethyl)-lH-pyrrole-2,5-dione hydrochloride (55.6 mg, 0.315 mmol), anhydrous dichloromethane (1.0 mL) and DIPEA (0.055 mL, 0.315 mmol) were added. The mixture stirred for an additional 5 hours at room temperature upon which the reaction was concentrated in vacuo. The resulting residue was purified by RP-HPLC (CI 8, CH3CN/H2O). Fractions containing desired product were frozen and lyophilized to give maleimide, D4 (20 mg, 16% yield) as a white solid. LCMS = 4.92 min (8 min method). MS (m/z): 1158.6 (M + 1)+.

134272-64-3, The synthetic route of 134272-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; MACROGENICS, INC.; HICKS, Stuart William; YODER, Nicholas C.; BARAT, Bhaswati; BONVINI, Ezio; DIEDRICH, Gundo; JOHNSON, Leslie S.; LOO, Deryk; SCRIBNER, Juniper A.; (260 pag.)WO2018/119196; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

766-36-9, 3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

766-36-9, Example 2Preparation of 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl ] benzene sulfonamide (IV)3-Ethyl-4-methyl-2,5-dihydro-lH- pyrrole-2-one (II) (1.0 Kg) and beta-phenylethyl isocyanate (1.488 Kg) were mixed in anhydrous toluene (4.0 L) and refluxed for 4 hrs. The toluene was distilled off and hexane (8.0 L) was added to the reaction mixture at 5O0C. The product precipitated is cooled to 0 to 5 C to obtain the solid compound viz. 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene (2.17 Kg). It was filtered washed with 2.0 L of hexane.To a cooled (15 to 25 C) solution of chlorosulfonic acid (2.8 L), 4-[2-(3-Ethyl-4- methyl-2-carbonyl pyrrolidine amido) ethyl] benzene (2.0 Kg) was added in small portions over a period of 2 to 3 hrs. Further it was stirred for 30 min at this temperature and then temperature was gradually raised to 30 to 350C. The reaction mass is stirred further for 2 hrs. The reaction mixture was then quenched into ice- water and stirred for 1 hr and filtered to obtain the product 4-[2-(3-Ethyl-4-methyl-2- carbonyl pyrrolidine amido) ethyl] benzene sulfonyl chloride (2.0 kg). To a cooled (15 to 200C) solution of diluted ammonia (1.4 L) 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonyl chloride was added in small portion over 1 to 2 hrs. The reaction mixture was then heated to 7O0C for 2 hrs when ammonolysis is complete. The product converted is then stirred for 1 hr at R.T. and filtered and dried at 90. to 100 C to obtain crude 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (2.2 Kg) having HPLC purity in the range of 82 to 88percent. The crude compound 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide (2.2 Kg) is then purified from mixture of organic solvents chosen from Methanol, Acetone toluene.

The synthetic route of 766-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; USV LIMITED; WO2006/103690; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-methoxycarbonyl-dibromomaleimide (4)0::xcTo a solution of dibromomaleimide (1.00 g, 3.9 mmol) and N-methylmorpholine (0.433 mL, 3.9 mmol) in THF (35 mL) was added methylchloroformate (0.304 mL, 3.9 mmol) and the mixture was stirred for 20 mm. at room temperature. Then CH2C12 (40 mL) was added, the organic phase was washed with H20, dried over MgSO4 and the solvent removed in vacuo to yield the desired product as a pink powder (1.18 g, 3.8 mmol, 97%).m.p. 115-118C; Vmax (cm?) 3236, 2962, 1809, 1769, 1730, 1602; oH (CDC13, 500MHz)4.00 (3H, s, CH3); Oc (CDC13, 125 IVIHz) 159.3, 147.0, 131.5, 54.9; MS (CI) m/z (%)314 (MPH, 100), 206 (13), 111(12); Mass calculated for C6H3O4N79Br2: 310.8423,observed: 310.8427., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; SMITH, Mark Edward Brennan; WO2013/121175; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem