Month: September 2020

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of Diels-Alder Surfactant-Carboxylate Headgroup; A second embodiment of the precursor surfactant molecule of the present invention is prepared by providing a solution in an essentially identical process as was used to prepare molecule 4. In the present embodiment, 3.68 g (16.9 mmol) of n-(4-carboxyphenyl)maleimide (molecule 2) was added to a solution of 5.72 g (24.2 mmol) of 2-n-dodecylfuran (molecule 3) and 30 mL of acetone and heated to 55 C. The solution was again stirred and allowed to react at 55 C. until TLC (SiO2, 1:1 acetone-petroleum ether) indicated the starting materials had been consumed. The reaction was then concentrated to dryness, the residue purified by flash chromatography on 60 silica gel in a 1:4 mixture of acetone and chloroform acting as a carrier solvent and subsequently recrystallized in a mixture of chloroform and petroleum ether to yield 5.37 g (70% yield) of a second colorless solid precursor material again characterized using 1H/13C NMR and combustion analysis for confirmation of primary structure. The prepared isomer was identified as exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-carboxyphenyl)imide and is designated, hereinafter, as molecule 5., 17057-04-4

17057-04-4 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid 86925, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Sandia National Laboratories; US7022861; (2006); B1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57079-01-3,11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid,as a common compound, the synthetic route is as follows.

57079-01-3, S1, 28.1 g of undecylmaleimido-11-acid is added to 120 ml of thionyl chloride,The reaction solution was heated to reflux for 3 h until the bubbler had no gas, and the reaction was stopped.The reaction solution was concentrated to dryness.Obtaining a yellow solid without post-treatment, directly proceeding to the next reaction;

The synthetic route of 57079-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Haofan Biological Co., Ltd.; Lv Minjie; Wang Guichun; Liu Min; (14 pag.)CN109535058; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 500 ml three-necked flask, N-maleimidyl acetic acid (94 g, 0.6 mol)And dichloromethane 300ml,Oxalyl chloride (90 g, 0.72 mol) was then added,The reaction was warmed to reflux, a large amount of gas was released.After 2h the reaction became clear,Concentrate to remove methylene chloride and excess oxalyl chloride,Addition of 200 ml of methylene chloride to remove the residual acid in one pass afforded crude N-maleimidoacetyl chloride.The crude product was dissolved in 200 ml of dichloromethane,Was added dropwise to N-hydroxysuccinimide (69 g, 0.6 mol)Triethylamine (80.8 g, 0.8 mol)Dissolved in 300 ml of dichloromethane,Ice water cooling control temperature does not exceed 20 , drip finished room temperature 2h.The reaction solution was washed with 200 ml of water to remove triethylamine hydrochloride,1N hydrochloric acid 100ml washing to remove excess triethylamine,200ml saturated salt water, washed and dried,Concentrated to dry off like white solid 137g,After recrystallization from a mixed solvent of ethyl acetate and petroleum ether, 116 g of a white solid was obtained,HPLC purity 98.7%, 76.7% yield.

25021-08-3, The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Haofan Biological Technology Co., Ltd.; Lv Minjie; Zhang Haiyan; Wang Guichun; Sun Fangchao; (10 pag.)CN105037237; (2017); B;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.

To a solution of BP-1 (47 mg, 0.218 mmol) intetrahydrofuran (8 mL) were added N-ethylcarbodiimide hydrochloride (50 mg, 0.262 mmol), hydroxybenzotriazole (35 mg, 0.262 mmol), N-methylmorpholine (72 muL,0.654 mmol) and compound 3 (60 mg, 0.24 mmol, see the details in Supplementary Material). The mixture solution was stirred for 5 h under argon at room temperature (25 C).Solvent was evaporated under vacuum, and the residue was extracted with dichloromethane (3 ¡Á 10 mL) and deionized water. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4and concentrated. The residue was purified by silica gel column chromatography (eluent: 25% ethyl acetate in n-hexane) to afford BP-3as a bright yellow solid (98 mg, 61%). 1H NMR (CDCl3,300 MHz, 293 K): delta 6.40 (2H, m), 7.05 (2H, m), 7.20 (2H,m), 9.77 (2H, s). 13C NMR (CD3CN, 75 MHz, 293 K):169.70, 169.59, 148.73, 135.12, 134.60, 134.02, 132.49,130.74, 128.05, 126.20, 123.60, 117.29, 115.82, 114.41,113.35, 50.16, 38.72. HRMS (FAB) m/z: C22H18BF2N5O3found 449.15 (M+).

17057-04-4, The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kim, Dokyoung; Ma, Donghee; Kim, Muwoong; Jung, Yuna; Kim, Na Hee; Lee, Chiho; Cho, Seo Won; Park, Sungnam; Huh, Youngbuhm; Jung, Junyang; Ahn, Kyo Han; Journal of Fluorescence; vol. 27; 6; (2017); p. 2231 – 2238;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0001236] To a mixture of Example 2.160.3 (557.5 mg), 2-(2,5-dioxo-2,5-dihydro- lH-pyrrol-l- yl)acetic acid (272 mg) and 0-(7-azabenzotriazol-l-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (667 mg) inN N-dimethylformamide (1.75 mL) at 0 C was added Nu,Nu- diisopropylethylamine (0.459 mL). The resulting mixture was stirred at 0 C for 1 hour. The reaction mixture was mixed with saturated aqueous NH4C1 mixture, extracted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography, eluting with petroleum ether/ ethyl acetate (2/1), to provide the title compound. MS (LC-MS) m/e 795.3 (M+Na) +., 25021-08-3

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBVIE INC.; TAO, Zhi-Fu; DOHERTY, George; WANG, Xilu; SULLIVAN, Gerard M.; SONG, Xiaohong; KUNZER, Aaron R.; WENDT, Michael D.; MARIN, Violeta L.; FREY, Robin R.; CULLEN, Steve C.; WELCH, Dennie S.; SHEN, Xiaoqiang; BENNETT, Nathan B.; HAIGHT, Anthony R.; ACKLER, Scott L.; BOGHAERT, Erwin R.; SOUERS, Andrew J.; JUDD, Andrew S.; (623 pag.)WO2016/94509; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(l) 4-a2S,5S)-37-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-Isopropyl-2-methyl-4,7,35-trioxo-10,13,16,19,22,25,28,31-octaoxa-3,6,34-triazaheptatriacontanamido)benzyl (3-(3,5-bis((((S)-7-methoxy-2-methyl-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)methyl)phenyl)prop-2-yn-1-yl)carbamate 15 Mal-dPEG 8 acid (0.053 g, 0.09 mmol, 0.9 eq.) and EDCI (0.017 g, 0.09 mmol, 0.9 eq.) were added to a solution of crude amine 14 (0.094 g, 0.095 mmol, 1 eq.) in DCM. The solution was stirred at room temperature for 2 hours. The reaction mixture was washed with water, saturated brine, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography (Biotage Isolera) to give material which was further purified by prep HPLC (without the use of acid). This afforded two batches of the desired product 15 (5.47 mg, and 2.78 mg of purity 93% and 88% respectively).

1334177-86-4, 1334177-86-4 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 51340955, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; GREGSON, Stephen John; LEVY, Jean-Noel; (88 pag.)US2017/239365; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EDCI hydrochloride (8 mg, 0.042 mmol) was added to a suspension of Maleimide-PEG8-acid (25 mg, 0.042 mmol) in dry CH2CI2 (4 mL) under argon atmosphere. PBD 19 (42 mg, crude) was added straight away and stirring was maintained until the reaction was complete (3 hours). The reaction was diluted with CH2CI2 and the organic phase was washed with H20 and brine before being dried over MgS04, filtered and excess solvent removed by rotary evaporation under reduced pressure by rotary evaporation under reduced pressure. The product was purified by careful silica gel chromatography (slow elution starting with 100% CHCI3 up to 9: 1 CHCI3/MeOH) followed by reverse phase HPLC to remove unreacted maleimide-PEGs-acid. The product 20 was isolated in 10% over two steps (6.6 mg). LC/MS 1 .16 min (ES+) m/z (relative intensity) 770.20 ([M + 2H]+ , 40%)., 1334177-86-4

1334177-86-4 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid 51340955, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SPIROGEN SARL; HOWARD, Philip Wilson; TIBERGHIEN, Arnaud; CAILLEAU, Thais; WO2015/52321; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of NHS ester, 7a (5 mg, 4.82 muetaiotaomicron) and l-(2-aminoethyl)-lH-pyrrole- 2,5-dione hydrochloride (1.7 mg, 9.64 muiotaetaomicron) in anhydrous dichloromethane (200 mu) was added DIPEA (1.512 mu, 8.68 muiotaetaomicron) under nitrogen. The mixture was stirred at room temperature for 4 hours and then concentrated in vacuo. The resulting residue was purified by RP-HPLC (CI 8, CH3CN / H20). Fractions containing desired product were frozen and lyophilized to give maleimide, compound D7 (3.5 mg, 68% yield). LCMS = 4.61 min (15 min method). MS (m z): 1062.8 (M + 1)+., 134272-64-3

The synthetic route of 134272-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; CHITTENDEN, Thomas; DECKERT, Jutta; HICKS, Stuart, William; LAI, Katharine, C.; PARK, Peter, U.; RUI, Lingyun; TAVARES, Daniel, J.; KOHLI, Neeraj; (274 pag.)WO2018/129029; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

6913-92-4, Step 1 : To an ice-cooled solution of 26a (4.77g, 30mmol), 98% H2SO4 (1.95mL), H2O (4.5mL) and acetone (3OmL) was added 85% mCPBA (7.9 Ig, 39mmol) with stirring. The mixture was allowed to react for 48hrs at r.t. Acetone was evaporated and the mixture was neutralized with IN aq. NaOH and extracted with toluene. The organic phase was dried over anhy. MgSO4 and evaporated. The residue was purified by column chromatography (EArPE=I :4) to provide 26b (2.Og, 38%).

The synthetic route of 6913-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XCOVERY, INC.; WO2008/33562; (2008); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1334177-86-4, EDCI hydrochloride (8 mg, 0.042 mmol) was added to a suspension of Maleimide-PEG8-acid (25 mg, 0.042 mmol) in dry CH2Cl2 (4 mL) under argon atmosphere. PBD 85 (42 mg, crude) was added straight away and stirring was maintained until the reaction was complete (3 hours). The reaction was diluted with CH2Cl2and the organic phase was washed with H2O and brine before being dried over MgS04, filtered and excess solvent removed by rotary evaporation under reduced pressure by rotary evaporation under reduced pressure. The product was purified by careful silica gel chromatography (slow elution starting with 100% CHCI3 up to 9:1 CHCl3/MeOH) followed by reverse phase HPLC to remove unreacted maleimide-PEG8-acid. The product 86 was isolated in 10% over two steps (6.6 mg). LC/MS 1 .16 min (ES+) m/z (relative intensity) 770.20 ([M + 2H]+ , 40%).

As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.

Reference£º
Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (283 pag.)WO2016/166298; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem