Month: September 2020

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EDCI.HCI (56 mg, 0.29 mmol, 3 eq.) was added to a stirred solution of bis- amine (9) (0.123 g, 98 pmol, 1.0 eq.) and MaldPEGOH (0.128 g, 0.22 mmol, 2.2 eq.) in CHCI3 (15 mL). The reaction mixture was stirred at room temperature for 30 min then diluted with CHCI3 (50 mL) washed with H2O (100 mL), saturated brine (100 mL), dried (MgS04) and evaporated under reduced pressure. Purification by preparative HPLC followed by lyophilisation gave the product as a white foam (0.047 g, 20%). Analytical Data: LC/MS,RT 6.61 min; MS (ES+) m/z (relative intensity) 1205 ([ M + 2H]+, 55)., 1334177-86-4

The synthetic route of 1334177-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MEDIMMUNE LIMITED; MASTERSON, Luke; VIJAYAKRISHNAN, Balakumar; CHRISTIE, Ronald, James; (118 pag.)WO2019/224340; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

2973-17-3, 1-Allyl-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of maleimide 3 (0.24 mmol), anthrone 2 (0.2 mmol), and the catalyst (20 mol %) in 1,2-dichloroethane (0.6 mL) at -10 C was stirred for 12 h (monitored by TLC). After evaporation under reduced pressure, the residue was purified through column chromatography on silica gel (petroleum ether/ethyl acetate=3/1) to yield pure products.

2973-17-3, As the paragraph descriping shows that 2973-17-3 is playing an increasingly important role.

Reference£º
Article; Bai, Jian-Fei; Guo, Yun-Long; Peng, Lin; Jia, Li-Na; Xu, Xiao-Ying; Wang, Li-Xin; Tetrahedron; vol. 69; 3; (2013); p. 1229 – 1233;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

17057-04-4, As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

General Procedure for the synthesis of Pauson-Khand adducts. To a solution of the acetylene (1.1 eq) (of general formula III (see above)) in 1,2-dichloroethane, was added Co2(CO)8 (1.1 eq) and the mixture was stirred 2 hours at room temperature. A solution of the pyrroline (1 eq) (of general formula II (see above and different examples 0 below)) in 1,2-dichloroethane and the additive (dimethylsulfoxide or cyclohexylamine) (3.5 eq) were added and the mixture was heated at 83C for 20 hours. The reaction mixture was filtered through celite and washed with CH2Cl2. The filtrate was concentrated and the crude was purified by flash chromatography. From phenylacetylene (5.0 g, 48.3 mmol), Co2(CO)8 (16.5 g, 48.3 mmol), 1-benzyl-3-pyrroline (7.0 g, 43.9 mmol), dimethylsulfoxide (12-0 g, 153.8 mmol) and 1,2-dichloroethane (200 ml). Purification: silica gel, gradient dichloromethane to dichloromethane:methanol 1%, afforded the product (5.9 g, 46%) as yellow oil. 1H NMR (400 MHz, CDCl3): delta (ppm) 7.72 (m, 2H), 7.65 (d, J=3Hz, 1H), 7.40-7.18 (m, 8H), 3.49-3.63 (AB system, 2H), 3.36 (m, 1H), 3.19 (d, J=9Hz, 1H), 2.94 (m, 1H), 2.83 (d, J=9Hz, 1H), 2.43 (t, J=9Hz, 1H), 2.37 (t, J=9Hz, 1H). 13C NMR (75 MHz, CDCl3) delta (ppm) 208.94, 159.74, 143.79, 138.30, 131.47, 128.45, 128.38, 128.34, 128.18, 58.91, 56.79, 55.89, 50.24, 42.58. MS (El+) m/z: 289.14 (M+)., 6913-92-4

6913-92-4 1-Benzyl-3-pyrroline 561506, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; EP1849770; (2007); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57079-01-3,11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid,as a common compound, the synthetic route is as follows.,57079-01-3

Example L1a 11-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-undecanoyl chloride 2.0 g (7.11 mmol) of 11-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-undecanoic acid is mixed with 15.5 ml of thionyl chloride and refluxed for 15 minutes. After cooling, it is mixed with toluene and evaporated to the dry state. 2.13 g (max. 7.11 mmol) of the title compound, which is further reacted without purification, is isolated.

57079-01-3 11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid 4618600, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Klar, Ulrich; Willuda, Joerg; Menrad, Andreas; Bosslet, Klaus; US2005/234247; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

17057-04-4, 17057-04-4 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid 86925, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

A suspension of 2,5-dihydro-2,5-dioxopyrrol-1-ylacetic acid (821 mg) in thionyl chloride (15.9 ml) was heated under reflux for 0.5 hours and the excess thionyl chloride was removed under vacuum. The residue was evaporated twice with dry toluene to afford 2,5-dihydro-2,5-dioxopyrrol-1-ylacetyl chloride [(5) where m=1] as a colourless, readily hydrolyzed liquid. (The compound has been prepared previously by a less convenient route5).

25021-08-3, As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Medical Research Council; US5434272; (1995); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

511 mg (1.95 mmol) of triphenylphosphine was dissolved in 5 mL of anhydrous THF and stirred.0.38 mL (1.95 mmol) of azoxylene diisopropyl ester was added dropwise to the above solution, and stirred at -78 C for 5 min.After 0.25 mL (1.56 mmol) of triethylene glycol monomethyl ether was dissolved in 5 mL of anhydrous THF, the reaction mixture was added dropwise to the azoazolyl diisopropyl ester solution, and stirring was continued at -78 C for 5 min.Thereafter, neopentyl alcohol 121 mg (1.37 mmol) was dissolved in 2 mL of anhydrous THF, added to triethylene glycol monomethyl ether, and stirred at -78 C for 5 min.Finally, 497 mg (1.95 mmol) of dibromomaleimide was added to the above reaction solution, stirred at -78 C for 10 min, then transferred to room temperature, and magnetically stirred at room temperature for 20 h.The crude product was purified by column chromatography (volume ratio EA_PA=1:10-1:4), and then isolated by medium pressure to obtain the white target product, intermediate 1 325 mg, yield 52.2%.

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Henan Normal University; Jiang Tao; Wang Zhiying; Wang Jie; Chi Yanwei; Dong Wenpei; Zhang Yue; Xin Pengyang; Chen Changpo; (11 pag.)CN109293683; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A cooled suspension (0 C) of molecule 3 (211 mg, 0.97 mmol) in methylene chloride (4.5 mL) was treated with triethylamine (190 mu, 1.36 mmol) and isobutyl chloroformate (175 mu, 1.34 mmol). The mixture was stirrred for 1 h at 0C and at room temperature (22 C) for about 1 h. Afterwards, tert-butyl carbazate (128 mg, 0.97 mmol) dissolved in methylene chloride (0.8 mL) was added dropwise to the mixture and stirred for an additional 12 h at 22C. The reaction mixture was diluted with ethyl acetate (55 mL) and methylene chloride (20 mL) and washed twice with saturated NaHC03(2 x 50 mL), twice with 0.1 N HCl (2 x 50 mL), twice with saturated NaCl (2 x 50 mL), and finally with H20 (50 mL). The organic phase was dried (MgS04) and evaporated to give crude derivative 4. The product was purified by flash chromatography, using a mixture of hexanes / acetone (3/2), to yield 173 mg (54%) of 4. The spectral data of this derivative correspond to those reported in the literature.10IR (v, cm”1): 3360-3240 (NH), 3087 (C=C), 2988 (CH, aliphatic), 1733 (C=0), 1706 (C=0); 1H NMR (acetone-d6, delta ppm): 9.05 (s, 1H, NH), 8.02 and 7.53 (2 x d, J=8.6 Hz, 4H, aromatic), 7.07 (s, 2H, maleimide), 2.84 (br s, 1H, NH), 1.45 (s, 9H, 3 x CH3);13C NMR (acetone-d6, delta ppm): 169.3 (2), 166.0, 155.7, 135.1, 134.6 (2), 131.6, 127.9 (2), 125.9 (2), 79.6, 27.5 (3); ESI+HRMS: (M+Na)+ calculated for C16H17N3NaO5 = 354.1060; found = 354.1072; (M -2-methylpropene +H)+ calculated for C12H11N3O5= 276.0620; found = 276.0627., 17057-04-4

17057-04-4 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid 86925, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; 3R VALO, S.E.C.; BERUBE, Gervais; REYES-MORENO, Carlos; (121 pag.)WO2017/177316; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the NHS ester, 6b (12.3 mg, 0.011 mmol) and N-(2- aminoethyl)maleimide hydrochloride (2.0 mg, 0.011 mmol) in anhydrous dichloromethane (0.3 mL) was added DIPEA (0.0022 mL, 0.013 mmol). The mixture was stirred at room temperature for 3 hours then it was stripped under reduced pressure. The residue was purified by semi-preparative reverse phase HPLC (CI 8 column, CH3CN/H2O). The fractions that contained pure product were combined, frozen and lyophilized to give the desired maleimide, compound D6 (10 mg, 80% yield). LCMS = 8.3 min (15 min method). MS (m/z): 1181.8 (M + D+)., 134272-64-3

As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; YODER, Nicholas, C.; BAI, Chen; MILLER, Michael, Louis; (179 pag.)WO2017/4025; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem