Month: September 2020

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reaction of commercially available Boc-Gly-Gly-Gly-OH (compound 8) with Nhydroxyxuccinimide and EDC coupling agent affords compound 9. Reaction of compound 9 with 1-(2-aminoethyl)-maleimide HC1 in the presence of a base such as diisopropyl ethyl amine (DIPEA) followed by Boc deprotection with HC1 in methoxymethyl ether gives compound 10. Reaction of compound 10 with glutamic anhydride gives compound 11. Reaction of compound 11 with DM? using EDC as coupling agent will give the desired product compound 12.

134272-64-3, The synthetic route of 134272-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; WIDDISON, Wayne, C.; WO2014/134457; (2014); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

MeVal-Val-Dil-Dap-Phe-OtBu (compound 1, 35 mg, 0.044 mmol) was suspended in DMF (0.250 mL). 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid (11 mg, 0.049 mmol) and HATU (17 mg, 0.044 mmol) were added followedby DIEA (0.031 mL, 0.17 mmol). This reaction mixture was allowed to stir for 2.0 hr. HPLC analysis indicated completeconsumption of starting compound 1.[0565] Product was isolated via preparatory RP-HPLC, using a Phenomenex C12 Synergi Max-RP 80A Column (250x 21.20 mm). Eluent: linear gradient 10% to 80% MeCN/0.05% TFA (aq) over 8 minutes, then isocratic 80% MeCN/0.05%TFA (aq) for an additional 12 minutes. A total of 20 mg of pure product (14) was isolated (0.02 mmol, 46% yield). ESMSm/z 987.85 [M+H]+; 1019.41 [M+Na]+; 985.54 [M-H]-., 17057-04-4

As the paragraph descriping shows that 17057-04-4 is playing an increasingly important role.

Reference£º
Patent; Seattle Genetics, Inc.; Doronina, Svetlana O.; Senter, Peter D.; Toki, Brian E.; Ebens, Allen J.; Kline, Toni Beth; Polakis, Paul; Sliwkowski, Mark X.; Spencer, Susan D.; EP2486933; (2015); B1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

Trifluoroacetic acid/N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamide (1:1) 200 mg (0.805 mmol) of tert-Butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate, 150 mg (0.966 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 560 mul (3.2 mmol) of N,N-diisopropylethylamine were dissolved in 10 ml of dimethylformamide, and 459 mg (1.21 mmol) of HATU were added. The reaction mixture was stirred at RT for 30 minutes. The solvents were evaporated under reduced pressure and the residue was dissolved in dichloromethane. The organic phase was washed twice with 5% strength citric acid solution and dried over magnesium sulphate, and the solvent was evaporated under reduced pressure. The residue was purified using Biotage Isolera (silica gel, column 25 g SNAP, dichloromethane:methanol 98:2). This gave 276 mg (89% of theory) of tert-Butyl {2-[2-(2-{[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]amino}ethoxy)ethoxy]ethyl}carbamate. LC-MS (Method 1): Rt=0.67 min; MS (ESIpos): m/z=386 (M+H)+.

25021-08-3, 25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; WITTROCK, Sven; BERNDT, Sandra; GRITZAN, Uwe; FITTING, Jenny; STELTE-LUDWIG, Beatrix; JONES, Patrick; MAHLERT, Christoph; VOTSMEIER, Christian; SCHOeNFELD, Dorian; TRAUTWEIN, Mark; WEBER, Ernst; PAWLOWSKI, Nikolaus; GREVEN, Simone; GLUeCK, Julian Marius; HAMMER, Stefanie; DIETZ, Lisa; MAeRSCH, Stephan; (357 pag.)US2020/138970; (2020); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 mg (0.594 mmol) of tert-butyl (14-amino-3,6,9,12-tetraoxatetradec-1-yl)carbamate, 111 mg (0.713 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 410 mul (2.4 mmol) of N,N-diisopropylethylamine were dissolved in 6 ml of dimethylformamide, and 339 mg (0.892 mmol) of HATU were added. The reaction mixture was stirred at RT for 1 h and purified directly by preparative RP-HPLC (column: Reprosil 250*30; 10mu, flow rate: 50 ml/min, MeCN/water/0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 130 mg (43% of theory) of tert-butyl [17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]carbamate. LC-MS (Method 1): Rt=0.71 min; MS (ESIpos): m/z=474 (M+H)+., 25021-08-3

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1334177-86-4,1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid,as a common compound, the synthetic route is as follows.

EDCI .HCI (0.13 g, 0.66 mmol, 1 .1 eq.) was added to a cloudy solution of compound 21 (0.61 g, 0.6 mmol, 1 .0 eq.) and Mal-dPEG8-OH (0.393 g, 0.66 mmol, 1 .1 eq.) in CHCI3 (25 mL). The clear solution was stirred at room temperature for 1 .5h., diluted with CHC (100 mL) washed with brine (2 x 100 mL), dried (MgS04) and evaporated under reduced pressure to give a yellow foam. Purification by flash column chromatography [CHCb/MeOH 0% to 6% in 1 % increments gave the product as a white foam (0.786 g, 82%). Analytical Data: RT 1 .44 min; MS (ES+) m/z (relative intensity) 1586 {[M + H]+ ,40), 1609 {[M + Na]+ , 100)

1334177-86-4, As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.

Reference£º
Patent; MEDIMMUME LIMITED; HOWARD, Philip Wilson; DUNNY, Elizabeth; MASTERSON, Luke; (151 pag.)WO2017/137553; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1193-54-0, 3,4-Dichloro-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-(7-methoxynaphthalen-1-yl)ethanamine (compound 3, 101 mg, 0.5 mmol), sodium acetate (82 mg, 1.0 mmol) and cyclic anhydrides 1.0 mmol) in 5mL acetic acid was heated to reflux for 3 h in a round bottomed flask. After the completion of reaction (as evidenced by TLC), the resulting mixture was concentrated under reduced pressure and washed with ethyl acetate (10 mL¡Á3), then the concentrated organic layer was purified by column chromatography on silica gel to obtain pure product., 1193-54-0

As the paragraph descriping shows that 1193-54-0 is playing an increasingly important role.

Reference£º
Article; Chang, Ying; Pi, Weiyi; Ang, Wei; Liu, Yuanyuan; Li, Chunlong; Zheng, Jiajia; Xiong, Li; Yang, Tao; Luo, Youfu; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1672 – 1676;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

6913-92-4,6913-92-4, 1-Benzyl-3-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cyanonitrone 13 (550 mg, 3.44 mmol) and N-benzyl-3-pyrroline2 (1.3 mL, 6.83 mmol) were dissolved in toluene (4 mL) and themediumwas stirred for 2 h at 80 C under micro-waves irradiation.The solvent was removed under reduced pressure before purificationby silica gel column chromatography (eluent: EtOAc/toluene 1/10). This allowed the separation of a minor more mobileregioisomer (60 mg, 6%) from the main racemic cycloadduct expected(¡À)-17 (500 mg, 45%). Compound (¡À)-17: Yellowish oil.Rf 0.4 (1:4 EtOAc/toluene). 1H NMR (500 MHz, 80 C, toluene-d8)d 7.4e7.0 (m, 10H, HeAr), 4.28 (ddd, 1H, J 3.4 Hz, J 6.0 Hz,J 7.5 Hz, H-4), 4.15 (d, 1H, J 13.4 Hz, H-8), 3.80 (d, 1H, J 13.4 Hz,H-8), 3.29 (d, 1H, J 13.1 Hz, H-9), 3.23 (d, 1H, J 13.1 Hz, H-9), 3.07(d, 1H, J 3.6 Hz, H-6), 2.79 (ddd, 1H, J 4.0 Hz, J 7.8 Hz,J 11.6 Hz, H-3), 2.48 (dd, 1H, J 3.1 Hz, J 10.1 Hz, H-50), 2.22 (br s,1H, H-5), 2.17 (br m, 1H, H-20), 2.09 (br m, 1H, H-2). 1D NOE experimentswith selective irradiations (H-3, H-4, or H-6), showedsignals enhancements as follows: H-3 irradiation: enhancements ofH-2: 2.5%, H-2?: 1.9%, H-4: 2%, H-6: 1.1%; irradiation of H-4: enhancementsof H-3: 2.1%, H-5: 1.9%, H-5?: 1.4%; irradiation of H-6:enhancements of H-2: 2%, H-2?: 1.8%. 13C NMR (126 MHz, 80 C,toluene-d8): d 139.8 (Caear), 137.2 (Ca?-ar), 130.2, 129.5, 129.4,129.3, 128.6, 128.1 (10C-ar), 116.9 (C-7), 81.9 (C-4), 60.0 (C-9), 59.9(C-6), 59.8, 59.7 (C-5, C-8), 57.5 (C-2), 53.6 (C-3). HRMS-ESI, positivemode: m/z calcd for C20H22N3O [MH]: 320.1757; found:320.1767.Compound (¡À)-18: yellow clear oil. Rf 0.6 (1/4 EtOAc/toluene).1H NMR (500 MHz, toluene-d8) d 7.5e7.0 (m, 10H, HeAr), 4.40 (dd,1H, J 4.7 Hz, J 7.7 Hz, H-4), 3.71 (d, 1H, J 8.1 Hz, H-6), 3.39 (s,2H, H-9), 3.20 (d, 1H, J 17.2 Hz, H-7), 3.01 (d, 1H, J 10.8 Hz, H-50),2.77 (d, 1H, J 17.2 Hz, H-7), 2.71 (d, 1H, J 9.7 Hz, H-20), 2.64 (app.q, 1H, J 7.3 Hz, H-3), 1.73 (m, 2H, H-2, H-5). 13C NMR (126 MHz,toluene-d8) d 140.02 (Caear), 138.41 (Ca?-ar), 129.84,129.35, 129.35,129.31, 128.93, 128.02 (10C-ar), 115.00 (C-8), 82.19 (C-4), 76.02 (C-6), 59.54 (C-9), 59.28 (C-5), 58.04 (C-3), 56.60 (C-2), 42.16 (C-7). 2DNMR (HMBC) showed correlations between H-6 and aromaticcarbons, as well as correlations between methylene H-7 and C-8 inthe nitrile group. 1D NOE experiments with selective irradiations(H-3, H-4, or H-6), showed signals enhancements as follows: H-3irradiation: enhancements of H-2: 4.6%, H-4: 4.2%, H-6: 1.1%, HeAr:3.5%; irradiation of H-4: enhancements of H-3: 3.8%, H-5: 4.1%, H-5?: 1.2%; irradiation of H-6: enhancements of H-2?: 2.9%, H-5?: 0.3%,HeAr: 5.4%. HRMS-ESI, positive mode: m/z calcd for C20H22N3O[MH]: 320.1757; found: 320.1750.

6913-92-4 1-Benzyl-3-pyrroline 561506, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Cecioni, Samy; Aouadi, Kaiss; Guiard, Julie; Parrot, Sandrine; Strazielle, Nathalie; Blondel, Sandrine; Ghersi-Egea, Jean-Francois; Chapelle, Christian; Denoroy, Luc; Praly, Jean-Pierre; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 237 – 249;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2973-17-3,1-Allyl-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: (All the reactions were performed on 50mg scale of aldehyde.) A reaction mixture containing K2CO3 (80mol%), NHC precatalyst A (15mol%), maleimide 2 (1.5 equiv) and aldehyde 1 (1.0 equiv) in THF (2mL) under argon atmosphere was stirred at 50C for 30min to 2h. When the reaction was complete, the crude reaction mixture was allowed to attain room temperature, followed by filtration of the reaction mixture through a bed of celite. The residue was washed with ethyl acetate (5mL x 3) and the combined filtrate was evaporated under reduced pressure. The crude reaction mixture was purified by column chromatography on silica gel using solvent gradient of petroleum ether:ethyl acetate to furnish the desired products 4-13, 15-21 in 10-90% yield., 2973-17-3

The synthetic route of 2973-17-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ahire, Milind M.; Mhaske, Santosh B.; Tetrahedron; vol. 74; 16; (2018); p. 2079 – 2084;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3

Example 9:conversion of an amine to a maleimide moiety /V-(Methoxycarbonyl)maleimide (37) Methyl chloroformate (0.87 ml_, 11.3 mmol) was added slowly to a solution of maleimide (1.00 g, 10.3 mmol) and /V-methyl morpholine (1.24 ml_, 1 1.3 mmol) in EtOAc (80 ml_) at 0 C and stirred for 1 hr. The precipitate was separated out through filtration through a celite pad and the filtrate concentrated in vacuo. It was attempted to recrystallise the crude oil with hexane: CH2CI2 but no crystallisation occurred. The crude product was redissolved in EtOAc (100 ml_), adsorbed onto silica and purified using column chromatography (Hex: EtOAc 6:4) to yield a white solid (1 .07 g, 67%). 5H (CDCI3, 300 MHz): 6.83 (2H, s, CH-3/4), 3.94 (3H, s, CH3-2′) 8c (CDCI3, 100 MHz): 165.6 (C-2/5), 148.1 (C-1 ‘), 132.3 (C-3/4), 54.2 (C-2’)

541-59-3 Maleimide 10935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED; UNIVERSITY OF CAPE TOWN; DRIVER, Cathryn Helena Stanford; ZEEVAART, Jan Rijn; PARKER, Mohamed Iqbal; HUNTER, Roger; (67 pag.)WO2016/46793; (2016); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2,3-dibromomaleimide23 (1.0 mmol) in CH2Cl2 (20ml) Et3N (2.0mmol) and thiol (2.1mmol) were added under argon atmosphere and stirred for 3 h at room temperature. The reaction mixture was evaporated,and the crude product was purified by flash chromatography to give the desired compound.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem