With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.
23.0 mL (2216.4 mmol) of toluene, 5.0 g (22.8 mmol) of 4-maleimidebenzoic acid, 2.2 mL (30.4 mmol) of thionyl chloride, and 4 mL of toluene were placed in a 100 mL three-necked flask equipped with a stirrer and a cooling tube,0.36 mL (4.6 mmol) of N, N-dimethylformamide was added,And the mixture was stirred at 80 DEG C for 1 hour in a nitrogen atmosphere to complete the chlorination reaction. Thereafter, the volatile components were removed by distillation under reduced pressure,Maleimide benzoic acid chloride was obtained as yellowish white crystals.Then, 5.4 g (22.8 mmol) of the obtained 4-maleimide benzoic acid chloride,40.0 mL (353.7 mmol) of O-dichlorobenzene,2.0 g (5.7 mmol) of the compound (1)3.2 mL (22.8 mmol) of triethylamine was stirred for 1 hour while heating at 80 DEG C under a nitrogen atmosphere to complete the esterification reaction. Thereafter, the reaction solution was cooled to room temperature, the precipitate was collected, washed with methanol, and dried to obtain 4.1 g (5.5 mmol) of the compound (2) as yellowish white crystals. The obtained compound (2) was identified by chemical analysis to have a chemical structure represented by the following formula (1-1) (molecular weight: 748.7). It was also confirmed that the compound (2) exhibited thermotropic liquid crystallinity by observation under a polarizing microscope. Further, it was confirmed that the compound (2) showed good solubility in DMSO, DMF and NMP.
17057-04-4, The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Da I Sel Co., Ltd.; Na Ka-ta-ni-, -go-u-ji; I No-u-e-, -ge-i-jo; (17 pag.)KR2018/130526; (2018); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem