31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 3c: 3, 4-CIS-DIHYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ester To a solution of BENZYL 3-PYRROLINE-1-CARBOXYLATE (15 g, 90percent, 66.4 MMOL) IN THF (100 mL) and water (25 mL), was added osmium tetroxide (10 mL, 2.5 wt. percent solution in 2-methyl-2- propanol, 0.8 MMOL) and 4-methylmorpholine N-oxide (8.56 g, 73 MMOL) as solid. The mixture was stirred at room temperature overnight and CONCENTRATED, IN VACUO. The residue was re- dissolved in EtOAc (300 mL) and washed with aqueous NA2SO3 (1.5 G in 100 mL water) solution, aqueous NAHCO3 solution and brine. The combined aqueous layer was extracted once with EtOAc (100 mL). The combined organic extracts were dried over NA2SO4 and concentrated, in vacuo. The crude product was further purified by flash column chromatography eluting with 4-5 percent MeOH in CH2CI2 to give 15.26 G (97percent) of a white SOLID. H NMR (300 MHz, CDCl3) 8 7.34 (5H, m), 5.11 (2H, BS), 4.26 (2H, m), 3.66 (2H, m), 3.41 (2H, m), 1.56 (2H, bs).
31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER INC.; WO2005/21554; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem