With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
A mixture of tert-butyl (2-aminoethyl)carbamate (11.2 mL) and saturated NaHC03 (120 mL) was stirred vigorously at 0 C, to which compound 38 (10.0 g, 64.4 mmol) was added in portions. After stirring at 0 C for 30 min the reaction was warmed to r.t. and stirred for 1.0 h. The solid was then collected by vacuum filtration and then dissolved in ethyl acetate and washed with brine, dried over anhydrous Na2S04, filtered and concentrated to give a white foam (13.6 g, 87% yield)., 55750-48-6
The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HANGZHOU DAC BIOTECH CO, LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; GAI, Shun; YE, Hangbo; YANG, Chengyu; GUO, Huihui; ZHOU, Xiaomai; XIE, Hongsheng; TONG, Qianqian; CAO, Minjun; ZHAO, Linyao; JIA, Junxiang; LI, Wenjun; ZUO, Xiaotao; LIN, Chen; XU, Yifang; GUO, Zixiang; (274 pag.)WO2017/46658; (2017); A1;,
Pyrroline – Wikipedia
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