55750-48-6, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. An updated downstream synthesis route of 55750-48-6 as follows.
Compound 10 (CAS Reg. No. 73259-81-1, available from Chem-Impex, 50.0 mg, 0.245 mmol) was dissolved in 2 mL saturated sodium bicarbonate solution at RT. Compound 9 (CAS Reg. No. 55750-48-6, available from Sigma-Aldridge, 38.0 mg, 0.245 mmol) was added at 5 C. It took about 10 min for the suspension to become homogeneous and the reaction vessel was left in a freezer overnight. The mixture was acidified with 10% TFA and purified by preparative chromatography to give compound 7 (25.0 mg, 0.088 mmol, 35.9% yield) as a mixture of rotamers. MS: (+) m/z, 284.9 (M+l). For the major rotamer: NMR (400 MHz, METHANOL-di) delta ppm 1.38 (s, 9 H), 3.56 – 3.66 (m, 1 H), 3.69 – 3.80 (m, 1 H), 4.80 (dd, (0142) J=10.4, 4.3 Hz, 1 H), 6.87 (s, 2 H). Preparative chromatography conditions: Column: XBridge BEH Shield RP18 OBD Prep Column, 13thetaAlpha, 5 muiotaeta, 30 mm X 150 mm, 1/pkg [186002990], flow rate: 40 mL /min, 23 min gradient: 5-50%, acetonitrile (with 0.1% TFA)/ water (with 0.1% TFA). Fractions were collected at 20% acetonitrile in water.
This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. We look forward to the emergence of more reaction modes in the future.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; CONG, Qiang; GANGWAR, Sanjeev; RANGAN, Vangipuram S.; SUNG, Mei-Chen; (36 pag.)WO2017/196598; (2017); A1;,
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