Month: November 2020

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid, below Introduce a new synthetic route., 1334177-86-4

N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (28 mg, 0.146 mmol, I eq) was added to asolution of 42 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) inchloroform (5 mL). The reaction was stirred for 1.5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/I0% methanol] gave 43 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 mm; MS (ES+)m/z (relative intensity) 982.90 (100), 1963.70 (5).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid

Reference£º
Patent; SPIROGEN SARL; ADC THERAPEUTICS SARL; HOWARD, Philip Wilson; VAN BERKEL, Patricius Hendrikus Cornelis; WO2015/52534; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.25021-08-3, name is 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid. An updated downstream synthesis route of 25021-08-3 as follows.

200 mg (0.594 mmol) of tert-butyl (14-amino-3,6,9,12-tetraoxatetradec-1-yl)carbamate, 111 mg (0.713 mmol) of (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid and 410 mul (2.4 mmol) of N,N-diisopropylethylamine were dissolved in 6 ml of dimethylformamide, and 339 mg (0.892 mmol) of HATU were added. The reaction mixture was stirred at RT for 1 h and purified directly by preparative RP-HPLC (column: Reprosil 250¡Á30; 10mu, flow rate: 50 ml/min, MeCN/water, 0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 130 mg (43% of theory) of tert-butyl [17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]carbamate. LC-MS (Method 1): Rt=0.71 min; MS (ESIpos): m/z=474 (M+H)+.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; MARX, Leo; JOHANNES, Sarah Anna Liesa; STELTE-LUDWIG, Beatrix; DIETZ, Lisa; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (481 pag.)US2019/77752; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

2973-17-3, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.2973-17-3, name is 1-Allyl-1H-pyrrole-2,5-dione. An updated downstream synthesis route of 2973-17-3 as follows.

General procedure: A mixture of maleimide 3 (0.24 mmol), anthrone 2 (0.2 mmol), and the catalyst (20 mol %) in 1,2-dichloroethane (0.6 mL) at -10 C was stirred for 12 h (monitored by TLC). After evaporation under reduced pressure, the residue was purified through column chromatography on silica gel (petroleum ether/ethyl acetate=3/1) to yield pure products.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1-Allyl-1H-pyrrole-2,5-dione, you can also browse my other articles.

Reference£º
Article; Bai, Jian-Fei; Guo, Yun-Long; Peng, Lin; Jia, Li-Na; Xu, Xiao-Ying; Wang, Li-Xin; Tetrahedron; vol. 69; 3; (2013); p. 1229 – 1233;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1122-10-7, name is 3,4-Dibromo-1H-pyrrole-2,5-dione. An updated downstream synthesis route of 1122-10-7 as follows.

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1)., 1122-10-7

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 3,4-Dibromo-1H-pyrrole-2,5-dione. We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 17057-04-4, name is 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid, introduce a new downstream synthesis route., 17057-04-4

General procedure: To a solution of vinylallene 1 (0.29 g, 1mmol) in dry toluene (5 ml) was added a solution of N-(4-substituted-phenyl)maleimide 2a-g(1.5 mmol) or maleic anhydride 2 (0.15 g, 1.5 mmol) in the same solvent (5 ml) under an argonatmosphere, and the mixture was stirred for 15 min. Then, the mixture was heated at reflux forseveral hours (see Table 2, in the case of maleic anhydride 2 – for 12 hours). After the reactionwas completed as monitored by TLC (eluent: ethyl acetate-hexane 4:1), the solvents wereevaporated under reduced pressure to give a residue, which was purified by silica gel with ethylacetate/hexane as eluent to afford the cyclic products 4-[5-(Diphenylphosphinoyl)-4-isopropylidene-1,3-dioxo-1,3,3a,4,7,7a-hexahydroisoindol-2-yl]benzoic acid (3f). Pale yellow crystals, yield 80%, 0.41 g, mp 290-292 oC; IR (max, cm-1):1778 and 1709 (C=O), 1589-1605 (C=C-C=C), 1437, 1462 (Ph), 1150 (P=O). 1H NMR (600.1MHz, DMSO-d6): H 1.50 (s, 3H, CH3), 1.85 (s, 3H, CH3), 2.21 (m, 2H, H7), 3.62 (tt, J 7.2 Hz,J 4.9 Hz, 1H, H7a), 4.55 (d, J 7.2 Hz, 1H, H3a), 6.62 (tt, J 4.2 Hz, J 17.2 Hz, 1H, H6), 7.43-7.75(m, 10H, 2Ph), 8.05-8.20 (m, 4H, C6H4), 9.32 (1H, s, CO2H). 13C NMR (150.9 MHz, DMSO-d6):dC 23.6 (2CH3), 25.3 (J =8.1 Hz, C-7), 44.0 (J 4.9 Hz, C-7a), 46.7 (J 7.9 Hz, C-3a), 126.0-128.2(C6H4), 128.4-135.2 (2Ph), 134.0 (J 6.1 Hz, C-4), 136.3 (J 7.8 Hz, C(CH3)2), 146.3 (J =119.4 Hz,C-5), 149.0 (J 6.7 Hz, C-6), 169.9 (CO2H), 176.7 (C-1), 178.8 (C-3). 31P NMR (242.9 MHz,DMSO-d6): dP = 23.3. Anal. Calcd for C30H26NO5P (511.50): C, 70.44; H, 5.12; N, 2.74. Found:C, 70.48; H, 5.05; N, 2.70, 17057-04-4

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 17057-04-4. We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Ivanov, Ivaylo K.; Ismailov, Ismail E.; Christov, Valerij Ch.; ARKIVOC; vol. 2013; 4; (2013); p. 152 – 163;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.134272-64-3, name is N-(2-Aminoethyl)maleimide Hydrochloride, below Introduce a new synthetic route.

Reaction of commercially available Boc-Gly-Gly-Gly-OH (compound 8) with Nhydroxyxuccinimide and EDC coupling agent affords compound 9. Reaction of compound 9 with 1-(2-aminoethyl)-maleimide HC1 in the presence of a base such as diisopropyl ethyl amine (DIPEA) followed by Boc deprotection with HC1 in methoxymethyl ether gives compound 10. Reaction of compound 10 with glutamic anhydride gives compound 11. Reaction of compound 11 with DM? using EDC as coupling agent will give the desired product compound 12.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of N-(2-Aminoethyl)maleimide Hydrochloride. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; IMMUNOGEN, INC.; WIDDISON, Wayne, C.; WO2014/134457; (2014); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.63468-63-3, name is 2,5-Dihydro-1H-pyrrole hydrochloride. Here is a downstream synthesis route of the compound 63468-63-3. 63468-63-3

63468-63-3, To a solution of 2,5-dihydro-lH-pyrrole hydrochloride (12 g, 0.11 mol) in H2O (100 niL) was added EtOAc (100 niL) and K2CO3 (89 g, 0.64 mol). The mixture was stirred at RT for 30 min. Cbz-Cl (22 g, 0.13 mol) was added dropwise at 0C and the mixture was stirred for 1 h. The organic layer was separated and the aqueous layer was extracted with EtOAc (3×20 mL). The combined organic layers were dried over Na2SO4. The solvent was removed in vacuo to afford the crude product (25 g, 95%), as a light oil, which was carried directly to the next step.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 63468-63-3

Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.57079-01-3, name is 11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid. Here is a downstream synthesis route of the compound 57079-01-3. 57079-01-3

57079-01-3, N-Maleimidyunndecanoic acid (171.4 g, 0.61 mol) and ethyl acetate (300 ml) were added to a 500 ml three-necked flaskand then thionyl chloride (142 g, 1.21 mol) A lot of gas released.After refluxing for 3h,almost no gas was released, the ethyl acetate was removed by concentration and excess thionyl chloride was added, and 200 ml of ethyl acetate was added to remove the residualacidonce toobtain crude N-maleimido undecanoyl chloride.The crude product was dissolved in 200 ml of ethyl acetate and added dropwise to a solution of N-hydroxysuccinimide (92 g, 0.8 mol) and diisopropylethylamine (129 g, 1.0 mol) in 300 ml of ethyl acetate. IceWater cooling control temperature does not exceed 20 , drip finished room temperature stirring 3h.The reaction mixture was washed with 200 ml of water to remove diisopropylethylamine hydrochloride, 100 ml of 1N hydrochloric acid to remove excess diisopropylethylamine, 200 ml of saturated saline, washed, dried and concentrated to give196 g of a white solid, ethyl acetate and petroleum Ether mixed solvent was recrystallized to give a white solid 152g,HPLC purity 98.2%, yield 66.1%.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 57079-01-3

Reference£º
Patent; Suzhou Haofan Biological Technology Co., Ltd.; Lv Minjie; Zhang Haiyan; Wang Guichun; Sun Fangchao; (10 pag.)CN105037237; (2017); B;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate, introduce a new downstream synthesis route., 55750-48-6

55750-48-6, A mixture of N-Boc-ethylenediamine (5.6 mL, 35.4 mmol, 1.1 eq. ) and saturated NaHCO3(60 mL) was cooled to 0 , to which compound 409 (5.00 g, 32.2 mmol, 1.0 eq. ) was added in portions. After stirring at 0 for 30 min, the reaction was warmed to r.t. and stirred for 1 h. The precipitate was collected by filtration and washed with cold water, then dissolved in EtOAc and washed with brine, dried over anhydrous Na2SO4and concentrated to give a white solid (6.69 g, 87%yield) .

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 55750-48-6. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.1122-10-7, name is 3,4-Dibromo-1H-pyrrole-2,5-dione, below Introduce a new synthetic route., 1122-10-7

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 3,4-Dibromo-1H-pyrrole-2,5-dione

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem