Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1081-17-0
Corydalis bungeana Turcz. attenuates LPS-induced inflammatory responses via the suppression of NF-kappaB signaling pathway in vitro and in vivo
Ethnopharmacological relevance Corydalis bungeana Turcz. (C. bungeana) is one of traditionally used medicines in China and possesses various biological effects, such as anti-inflammatory, antibacterial activity and inhibition of the immune function of the host. Aim of the study we studied the anti-inflammatory effect and molecular mechanism involved of C. bungeana both in vitro and in vivo model system in which the inflammatory response was induced by LPS treatment. Materials and methods Anti-inflammatory activity of C. bungeana was investigated by LPS-induced RAW 264.7 macrophages and BALB/c mice. The production and expression of pro-inflammatory cytokines were evaluated by Griess reagent, ELISA kits and RT-qPCR, respectively. Phosphorylation status of IkappaBalpha and p65 was illustrated by western blot assay. Results C. bungeana reduced the secretion of NO, TNF-alpha, IL-6 and IL-1beta through inhibiting the protein expression of iNOS, TNF-alpha, IL-6 and IL-1beta in vitro and in vivo. Western blot analysis suggested that C. bungeana supressed NF-kappaB activation via regulating the phosphorylation of IkappaBalpha and p65. Immunohistochemical assay also demostrated the histological inflammatory change in liver tissue. Conclusions The results indicate that C. bungeana supresses the activation of NF-kappaB signaling pathway through inhibiting phosphorylation of IkappaBalpha and p65, which results in good anti-inflammatory effect. In addition, C. bungeana attenuates inflammatory reaction by supressing the expression of various inflammatory cytokines both in vivo and in vitro.
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem