Synthetic Route of 1081-17-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1081-17-0, Name is 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, molecular formula is C11H9NO3. In a Article£¬once mentioned of 1081-17-0
Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine
Studies are described on the cytochrome P450 (CYP) isoenzyme dependence of the main metabolic steps of the Eschscholtzia californica alkaloids californine and protopine using rat liver microsomes. Preparations of E. californica are in use as phytopharmaceuticals and as herbal drugs of abuse. CYP isoenyzme dependences were studied using specific chemical inhibitors for CYP1A2, CYP2D1, and CYP3A2 (alpha-naphthoflavone, quinine, and ketoconazole, respectively). CYP2C11 was inhibited by specific antibodies for lack of specific chemical inhibitors. Californine N-demethylation was mainly catalyzed by CYP3A2 and to a minor extent by CYP1A2 and CYP2D1, but not by CYP2C11. CYP2D1 and CYP2C11 were shown to be mainly involved in demethylenation of both, californine and protopine, while CYP1A2 and CYP3A2 showed only minor contribution. Kinetic parameters of the reactions were established. Km and Vmax values for the californine N-demethylation were 4.5¡À4.7 muM and 22.9¡À13.7 min/mg protein (high affinity) and 161.3¡À16.7 muM and 311.8¡À39.4 min/mg protein (low affinity), respectively. Californine demethylenation and protopine demethylenation showed substrate inhibition and Km and Vmax values were 5.0¡À0.5 and 7.1¡À0.6 muM and 83.3¡À2.6 and 160.7¡À4.0 min/mg protein, respectively.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1081-17-0, and how the biochemistry of the body works.Synthetic Route of 1081-17-0
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem