Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 38609-97-1, Name is 2-(9-Oxoacridin-10(9H)-yl)acetic acid, SMILES is O=C(O)CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O, belongs to pyrrolines compound. In a document, author is Schade, Markus, introduce the new discover, Computed Properties of C15H11NO3.
Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors
Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation of the adaptive immune system and many major diseases. Here, we used NMR fragment screening and crystal structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells. Noncovalent fragment hits revealed binding hotspots, while the covalent inhibitor structure-activity relationship enabled efficient potency optimization.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 38609-97-1 is helpful to your research. Computed Properties of C15H11NO3.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem