A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 67604-48-2, Name is 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, molecular formula is C15H12O5. In an article, author is Shrivash, Manoj Kumar,once mentioned of 67604-48-2, Safety of 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one.
Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase
Stereoselective aldoximes, preferably Z form have been obtained from ci-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C-C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality. (C) 2020 Published by Elsevier B.V.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem