In an article, author is Zhao, Xuna, once mentioned the application of 3317-61-1, Safety of 5,5-Dimethyl-1-pyrroline N-oxide, Name is 5,5-Dimethyl-1-pyrroline N-oxide, molecular formula is C6H11NO, molecular weight is 113.1576, MDL number is MFCD00005279, category is pyrrolines. Now introduce a scientific discovery about this category.
In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of beta-Oxoamides with Amine Hydrochlorides for the Synthesis of Pyrrolin-4-ones
A novel in situ generated TEMPO oxoammonium salt inediated one-pot tandem reaction has been developed for the straightforward construction of pyrrolin-4-ones from readily available beta-oxoamides with amine hydrochlorides. The reaction tolerates various functional groups and represents a reliable method for the synthesis of highly substituted pyrrolin-4-oes in good yields under mild conditions. Detailed mechanistic studies disclosed that TEMPO oxoammonium salt generated in situ was crucial for the transformation involving the formation of enaminone precursors in situ by condensation of the beta-oxoamides with amines, followed by sequential oxidative coupling with beta-oxoamides, intramolecular eyclization and 1,2-alkyl migration steps.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem