Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 67604-48-2, Name is 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, molecular formula is C15H12O5. In an article, author is Dolfen, Jeroen,once mentioned of 67604-48-2, Product Details of 67604-48-2.
Concise Synthesis of 3-(Aminomethyl)pyrrolizidines via an In(OTf)(3)-Mediated Ring Rearrangement of 2-[2-(1-Pyrrolin-2-yl)alkyl]aziridines
In this study, an efficient ring rearrangement of 2-[2-(1-pyrrolin-2-yl)alkyl]aziridines, prepared from 2-(bromomethyl) aziridines, toward novel trans-and cis-3-aminomethyl-substituted pyrrolizidines was developed. To that end, addition of In(OTf)(3) as an appropriate Lewis acid catalyst resulted in the formation of intermediate pyrrolizidinium salts via regioselective aziridine ring opening, which were then trapped by a hydride or cyanide nucleophile. Column chromatographic purification allowed the isolation of the major trans-isomers, exclusively.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem