Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Groselj, Uros, once mentioned the application of 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, molecular weight is 292.3782, MDL number is MFCD01730958, category is pyrrolines. Now introduce a scientific discovery about this category, Application In Synthesis of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine.
Synthesis of Spiro-Delta(2)-Pyrrolin-4-One Pseudo Enantiomers via an Organocatalyzed Sulfa-Michael/Aldol Domino Sequence
Delta(2)-Pyrrolin-4-ones undergo organocatalyzed sulfa-Michael/aldol domino spirocyclizations with mercaptoacetaldehyde dimer. The products contain three contiguous stereocenters (ee up to 99%, dr up to 95:5, 25 examples) and can be transformed into analogues of natural products. With the use of a single catalyst, the absolute configuration of the products were determined by the configuration of the exocyclic double bond of the starting material. These results point at the possibility of a widespread use of unsaturated Delta(2)-pyrrolin-4-ones in various (organo)catalyzed (cascade) transformations for accessing libraries of 3D-rich pyrrolone-based (spiro)heterocycles.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1977-07-7, Application In Synthesis of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem