New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.229625-50-7, Name is Di-tert-butyl chloromethyl phosphate, molecular formula is C9H20ClO4P, belongs to pyrrolines compound, is a common compound. In a patnet, author is Qiu, Xiao-Feng, once mentioned the new application about 229625-50-7, Recommanded Product: Di-tert-butyl chloromethyl phosphate.
Late-Stage Transformation of Carboxylic Acids to N-Trifluoroethylimides with Trifluoromethyl Diazomethane
We report the first systematic evaluation of the reaction of trifluoromethyl diazomethane (2,2,2-trifluorodiazoethane, CF3CHN2) with drug-like molecules. We found our previous copper-catalyzed transformation of carboxylic acids to the corresponding N-trifluoroethylimides with CF3CHN2 and acetonitrile is well-suited for the latestage modification of drug and drug-like acids. A procedure that enables the use of solid nitriles and nitriles with high boiling points as viable substrates is also disclosed.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 229625-50-7. Recommanded Product: Di-tert-butyl chloromethyl phosphate.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem