Chemical Research Letters, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. Computed Properties of https://www.ambeed.com/products/56-12-2.html,56-12-2, Name is 4-Aminobutyric acid, SMILES is O=C(O)CCCN, belongs to pyrrolines compound. In a document, author is Rostovskii, Nikolai, V, introduce the new discover.
Acid-catalyzed rearrangement of 1-acyl-2-azabuta-1,3-dienes to 4-pyrrolin-2-ones
1-Acyl-2-azabuta-1,3-dienes underwent rearrangement to 4-pyrrolin-2-ones in the presence of acidic catalysts (silica gel or ZnCl2) and water. The reaction proceededviathe formation of 2,3-dihydroxy-3,4-dihydropyrrole and 2-hydroxy-2H-pyrrole intermediates, the latter of which was transformed by [1,5]-sigmatropic shift of carbonyl substituent and prototropic isomerization. 4-Chloro-substituted 1-acetyl-2-azabuta-1,3-dienes were stable toward rearrangement, while brominated analogs rearranged into 4-pyrrolin-2-ones, probably as a result of the initial radical hydrodebromination. According to calculations performed at the DFT level, two steps of the reaction were catalyzed by acid: the cyclization of 2-azabutadiene and the sigmatropic shift in the 2-hydroxy-2H-pyrrole intermediate.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. 56-12-2, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/56-12-2.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem