Research speed reading in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 525-76-8, Name is 2-Methyl-4H-benzo[d][1,3]oxazin-4-one, molecular formula is C9H7NO2. In an article, author is Groselj, Uros,once mentioned of 525-76-8, Safety of 2-Methyl-4H-benzo[d][1,3]oxazin-4-one.
Synthesis of Spiro-Delta(2)-Pyrrolin-4-One Pseudo Enantiomers via an Organocatalyzed Sulfa-Michael/Aldol Domino Sequence
Delta(2)-Pyrrolin-4-ones undergo organocatalyzed sulfa-Michael/aldol domino spirocyclizations with mercaptoacetaldehyde dimer. The products contain three contiguous stereocenters (ee up to 99%, dr up to 95:5, 25 examples) and can be transformed into analogues of natural products. With the use of a single catalyst, the absolute configuration of the products were determined by the configuration of the exocyclic double bond of the starting material. These results point at the possibility of a widespread use of unsaturated Delta(2)-pyrrolin-4-ones in various (organo)catalyzed (cascade) transformations for accessing libraries of 3D-rich pyrrolone-based (spiro)heterocycles.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 525-76-8. Safety of 2-Methyl-4H-benzo[d][1,3]oxazin-4-one.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem