New Advances in Chemical Research, May 2021.Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 54663-78-4, Name is Tributyl(thiophen-2-yl)stannane, molecular formula is C16H30SSn, belongs to pyrrolines compound, is a common compound. In a patnet, author is Tayu, Masanori, once mentioned the new application about 54663-78-4, Name: Tributyl(thiophen-2-yl)stannane.
A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N-Arylynamides
Treatment of ynamides with a catalytic amount of TpRuCl(PPh3)(2) resulted in the construction of indole scaffolds known as privileged structure motifs. This reaction involved a cascade of 1,2-rearrangement and cyclization carrying out C-C bond formation via a ruthenium vinylidene intermediate, as revealed by a deuterium-labeling experiments. Furthermore, the transformation of multi-functionalized ynamide, derived from a practical drug molecule, showed a high functional group tolerance of this reaction.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 54663-78-4. Name: Tributyl(thiophen-2-yl)stannane.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem