New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.1953-02-2, Name is Tiopronin, molecular formula is C5H9NO3S, belongs to pyrrolines compound, is a common compound. In a patnet, author is Cores, Angel, once mentioned the new application about 1953-02-2, SDS of cas: 1953-02-2.
Three-component access to 2-pyrrolin-5-ones and their use in target-oriented and diversity-oriented synthesis
The Hantzsch-type microwave-assisted, solvent-free sequential three-component reaction between primary amines, beta-dicarbonyl compounds and alpha-bromoesters in the presence of indium trichloride afforded 2-pyrrolin-5-ones, which are difficult to access by alternative methods. Ready access to these compounds allowed their use as synthetic building blocks in a target-oriented project aimed at the synthesis of a compound that had previously been postulated as a candidate for HIV integrase inhibition on the basis of computational studies. The versatility of 2-pyrrolin-5-ones was further verified by their use in a diversity-oriented synthesis context, leading to a library of highly functionalized bispiro compounds. The overall process leading to these compounds involved the generation of six bonds and two cycles over three steps, two of which are multicomponent, and the fully controlled generation of up to four stereocenters, including two quaternary ones.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem