The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ) is researched.Synthetic Route of C4H6O3.Panek, James S.; Masse, Craig E. published the article 《Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I》 about this compound( cas:58081-05-3 ) in Journal of Organic Chemistry. Keywords: mycotrienin I mycotrienol synthesis convergent asym; chiral allylsilane bond construction; Stille coupling macrocyclization triene incorporation. Let’s learn more about this compound (cas:58081-05-3).
A highly convergent asym. synthesis of the ansamycin antibiotics (+)-mycotrienin I (I) (R = cyclohexylcarbonyl-D-Ala) and (+)-mycotrienol (I) (R = H) (II) has been achieved through the synthesis and coupling of the C9-C16 subunit (III) and the aromatic subunit (IV). All four stereogenic centers were introduced using chiral allylsilane bond construction methodol. A key feature of the synthetic scheme includes the incorporation of the (E, E, E)-triene unit with simultaneous macrocyclization via a Stille-type coupling-macrocyclization.
As far as I know, this compound(58081-05-3)Synthetic Route of C4H6O3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem