The Absolute Best Science Experiment for 4-Methoxy-1H-pyrrol-2(5H)-one

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Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors

The direct Mukaiyama-Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et3N mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly manipulable gamma-substituted pyrrolinone products were practically synthesized in acceptable to excellent yields, and with diastereoselectivities heavily relying upon the substituent at the nitrogen atom of the pyrrolinone donor.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem