Chemical Research Letters, May 2021.Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to bind in a process of adsorption. , Recommanded Product: Tiopronin, Introducing a new discovery about 1953-02-2, Name is Tiopronin, molecular formula is C5H9NO3S, belongs to pyrrolines compound. In a document, author is Liu, Zhuqing.
Selective 1,4-Addition of Organolithiums to Maleate Monoesters with Application for a Short Efficient Route to Azaindanones
The ability of maleate half-ester salts to serve as electrophilic partners in 1,4-conjugate addition reactions with control of regioselectivity has previously been explored in only a limited context with soft nucleophiles. We have demonstrated that benzylic anions of picolines, as well as enolates of ketones, esters, and nitriles, react with lithium 4-( tert -butoxy)-4-oxobutenoate in a completely regioselective manner. This new method was applied to an expedient two-step process for preparing a key azaindanone intermediate for the clinical-candidate drug MK-8666.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem