766-36-9,766-36-9, 3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-Ethyl-4-methyl-3-pyrrolin-2-one (300mg , 2.4mM), 2-Bromo-4-trifluoromethylpyridine (452 mg,2.0 mM), tris(dibenzylideneacetone)dipalladium (0) (37 mg, 0.04mM), xantphos (173 mg, 0.3mM) and caesium carbonate (978 mg, 3 mM) were dissolved in dioxane (5 mL), and heated in asealed vessel under nitrogen at 100 ¡ãC for 30 minutes in a microwave. The mixture was allowedto cool to ambient temperature, partitioned between water (30 mL) and ethyl acetate (30 mL). The aqueous phase was extracted with further ethyl acetate (2 x 20 mL). The ethyl acetate extracts were combined, washed with water (30 mL), dried over magnesium sulfate, filtered and evaporated to give N-(4-trifluoromethylpyrid in-2-yl )-3-m ethyl-4-ethyl-5-oxo-2 ,5-d ihyd ropyrrole asa yellow oil. This was purified by chromatography on silica to give 490 mg of a yellow oil that crystallised1H NMR (CDCI3), 8.80 (d, 1H), 8.45 (d, 1H), 7.19 (dd, 1H), 4.45 (s, 2h), 2.35 (q, 2H), 2.10 (s, 3H), 1.13 (t, 3H).
The synthetic route of 766-36-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; MORRIS, James Alan; HENNESSY, Alan Joseph; BOEHMER, Jutta Elisabeth; (99 pag.)WO2016/71360; (2016); A1;,
Pyrroline – Wikipedia
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