So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Yang; Xia, Yihong; Lai, Yongji; Tang, Fang; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Zhang, Yonghui; Zhang, Jinwen researched the compound: (R)-4-Hydroxydihydrofuran-2(3H)-one( cas:58081-05-3 ).Reference of (R)-4-Hydroxydihydrofuran-2(3H)-one.They published the article 《Efficient synthesis of kinsenoside and goodyeroside A by a chemo-enzymatic approach》 about this compound( cas:58081-05-3 ) in Molecules. Keywords: kinsenoside chemoenzymic synthesis; goodyeroside chemoenzymic synthesis. We’ll tell you more about this compound (cas:58081-05-3).
Kinsenoside (1) and goodyeroside A (2), two naturally occurring stereoisomers with diverse biol. activities, have been synthesized efficiently by a chemo-enzymic approach with a total yield of 12.7%. The aglycons, (R)- and (S)-3-hydroxy-γ-butyrolactone, were prepared from d- and l-malic acid by a four-step chem. approach with a yield of 75%, resp. These butyrolactones were then successfully glycosidated using β-D-glucosidase as a catalyst in a homogeneous organic-water system. Under the optimized enzymic conditions, the yields of kinsenoside and goodyeroside A in the enzymic steps both reached 16.8%.
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Reference:
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem