55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N-(Methoxycarbonyl)maleimide (315 mg, 2.03 mmol, 1 eq) was added to a solution of Boc- L-lysine (500 mg, 2.03 mmol, 1 eq) in 10 mL of saturated aqueous NaHCO3 at 0 0C. The mixture was stirred vigorously at 0 0C for 40 minutes and at room temperature for an additional hour. After cooling to 0 0C, the solution was acidified to pH 3.0 with concentrated H2S O4 before extracting with ethyl acetate. The organic layers were combined and dried over anhydrous MgSO4. After removing the solvent in vacuo, the residue was purified by column chromatography on silica gel using a mixture of CHCl3-MeOH (5:1, v/v) to provide the product (458 mg, 69%): 1H NMR delta 1.39-1.87 (6 H, m, (CH2)3), 1-44 (9H, s, Boc), 3.52 (2H, t, J – 7.2 Hz, NCH2), 4.25-4.30 (IH, m, CH), 5.15 (IH, d, NH), 6.70 (2H, s, maleimide)., 55750-48-6
The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ENZON PHARMACEUTICALS, INC.; WO2008/34124; (2008); A2;,
Pyrroline – Wikipedia
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