Author: Jessica.F

541-59-3, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.541-59-3, name is Maleimide. An updated downstream synthesis route of 541-59-3 as follows.

To a solution of maleimide (6.35 g, 65.4 mmol, 1.0 eq. ) in EtOAc (120 mL) were added N-methyl morpholine (8.6 mL, 78.5 mmol, 1.2 eq. ) and methyl chloroformate (6.0 mL, 78.5 mmol, 1.2 eq. ) at 0 . The reaction was stirred at 0 for 30 min and r.t. 1 h. The solid was filtered off and filtrate concentrated. The residue was dissolved in CH2Cl2and filtered through a silica gel plug and eluated with CH2Cl2to remove the color. The appropriate fractions were concentrated and resulted solid was triturated with 10%EtOAc/PE to give a white solid (9.00 g, 89%yield) .

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of Maleimide, you can also browse my other articles.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 144; 5-Methoxy-3,4-dihydro-2H-pyrrole and triethylamine were added to ethyl 3-oxo-3-(2, 4,5-trifluorophenyl)propanoate, for stirring at 60¡ãC for 4 days, to obtain ethyl 3-oxo-2-pyrrolidin-2-ylidene-3-(2,4,5-trifluorophenyl)propanoate., 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astellas Pharma Inc.; EP1650192; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution OF BENZYL-2, 5-DIHYDRO-LH-PYRROLE-L-CARBOXYLATE (10. OG, 49. 3MMOL) in THF (200mL) was treated with osmium tetroxide solution (2.5percent in TERT-BUTANOL, 5ML) and N-METHYLMORPHOLINE (6.90g, 59. 0MMOL) and the reaction mixture stirred at rt under argon for 72h. Aqueous sodium thiosulfate solution (10percent, 200mL) was added and the mixture stirred for a further lh and then concentrated in vacuo. The resulting aqueous layer was extracted with ethyl acetate (3 x 200mL) and the combined organic layers washed with aqueous sodium thiosulfate solution (10percent, 300mL) and hydrochloric acid (LN, 300mL). The organic fraction was dried (MgS04) and concentrated in vacuo to give the title compound as an off-white solid. ON (CDCl3): 2. 67 (2H, br s), 3.38-3. 45 (2H, m), 3.63-3. 67 (2H, m), 4.22-4. 26 (2H, M), 5.12 (2H, s), 7.30-7. 38 (5H, m); m/z (ES+) = 238 [M+ H] +., 31970-04-4

31970-04-4 Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate 643471, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl (2-aminoethyl)carbamate (11.2 mL) and saturated NaHC03 (120 mL) was stirred vigorously at 0 C, to which compound 38 (10.0 g, 64.4 mmol) was added in portions. After stirring at 0 C for 30 min the reaction was warmed to r.t. and stirred for 1.0 h. The solid was then collected by vacuum filtration and then dissolved in ethyl acetate and washed with brine, dried over anhydrous Na2S04, filtered and concentrated to give a white foam (13.6 g, 87% yield)., 55750-48-6

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO, LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; GAI, Shun; YE, Hangbo; YANG, Chengyu; GUO, Huihui; ZHOU, Xiaomai; XIE, Hongsheng; TONG, Qianqian; CAO, Minjun; ZHAO, Linyao; JIA, Junxiang; LI, Wenjun; ZUO, Xiaotao; LIN, Chen; XU, Yifang; GUO, Zixiang; (274 pag.)WO2017/46658; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-pyrrolidinone was combined with dimethylsulphate in benzene and refluxed for 3 h. After purification including distillation, the resulting 2-methylimino ester pyrrolidine was combined with excess lithium phenoxide (PhLi) in dry ether at room temperature for 18 h to yield the title compound.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Benkovic, Stephen J.; Shapiro, Lucy; Wright, Rachel; Stephens, Craig; Kahng, Lyn Sue; Berdis, Anthony; Lee, Irene; US2005/227933; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate (2.00 g, 9.80 mmol) in CH2Cl2 (10 mL) was added slowly 3-chloroperbenzoic acid (3.00 g, 14.80 mmol) at 0¡ã C. The reaction mixture was stirred for 13 h at room temperature, then quenched with saturated sodium thiosulfate aqueous solution and extracted with EtOAc. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 6:1 (v/v) PE/EtOAc) to give the title compound as colorless oil (1.75 g, 81.02percent)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; Zhang, Jiancun; Zhang, Yingjun; Zhang, Weihong; Liu, Bing; Zhang, Jiquan; Liu, Jinlei; Zhang, Lu; US2014/228361; (2014); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, General procedure: The maleimide was added to a suspension of P25 in methanol (10%) and acetonitrile (90%). The resulting mixture was then purged with argon for 15 min. The mixture was irradiated with eight 29 cm 15 W Philips Cleo tubes (lambda = 350 nm). Following irradiation the P25 powder was removed via filtration through Celite.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manley, David W.; Buzzetti, Luca; MacKessack-Leitch, Andrew; Walton, John C.; Molecules; vol. 19; 9; (2014); p. 15324 – 15338;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 2; Ci5-l-methyl-3 (9Z,12ZVocta^^; Benzyl 3,4-dihvdroxypyrrolidine-l-carboxylate (9): In a 500 mL RBF, the Cbz Pyrroline (15 gs 73.8 mmol) was dissolved in a mixture of 100 mL THF, 60 mL t-BuOH and 40 mL water for addition of the NMO (30.6 ml, 148 mmol) solution followed by the osmium tetraoxide (0.925 ml, 0.074 mmol) solution. Heated in a 70C oil bath. Solution slowly went from yellow to brown. After 2h, cooled to RT and added 50 mL 10percent aqueous NaHS03. Concentrated and partitioned between 100 mL brine and 100 mL EtOAc. Separated layers and extracted with 100 mL EtOAc. Dried over MgS04, filtered and concentrated to 22.3 g of thick yellow oil. Flash column chromatography from 50-100percent EtOAc in hexane provided compound 9. .H NMR (400 MHz, CDC13) 5 7.35 (m, 5H), 5.22 (s, 2H), 4.42 (m, 4H), 3.63 (m, 2H), 3.42 (m, 3H), 3.20 (m, IH)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; STANTON, Matthew, G.; BEUTNER, Gregory, L.; WO2012/61259; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.,55750-48-6

[ 4313] 30 mg (30 f.tmol) oflntermediate 89 were taken up in2 ml of 1 ,4-dioxane and admixed with 4 ml of saturatedsodium hydrogencarbonate solution and then with 7.5 mg (50f.tmol) of methyl 2,5-dioxo-2,5-dihydro-18-pyrrole-1-carboxylate.The reaction mixture was stirred at RT for 1 handthen concentrated in vacuo. The remaining residue was purifiedby means of preparative HPLC. After lyophilization, 24mg (74% of theory) of the title compound were obtained.[4314] HPLC (Method 5): R,=2.2 min;[4315] LC-MS (Method 1): R,=l.Ol min; MS (ESipos):rnlz=1006 (M+Hr.

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

The reaction mixture comprising 1 mmol of 1-[N-(5,5-dimethyl-3,4,5,6-tetrahydropyrimidinium-2-yl)amino]dodecane-12-ammonium ditrifluoroacetate, 1 mmol (1 eq.) of 3,4-dihydro-5-methoxy-2H-pyrrole and 0.5 ml of triethylamine in 10 ml of absolute ethanol is heated under reflux for 20 hours. After cooling down to ambient temperature, the reaction mixture is evaporated to dryness and chromatographed on a silica column (CH2Cl2/CH3OH/NH4OH 85:13:2) in order to produce the product, in the form of an oil, with a yield of 65percent. NMR 1H (CD3OD, 360 MHz), delta (ppm): 1.12 (s, 6H); 1.36 (m, 16H); 1.60 (n, 2H); 1.69 (m, 2H); 2.28 (m, 2H); 2.93 (m, 2H); 3.09 (s, 4H); 3.22 (m, 2H); 3.31 (m, 2H); 3.75 (m, 2H). MS-ES+: [M+H]+: 378; [M+H+TFA]+: 492; [M+2H]++/2: 189.5

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2005/176819; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem