Category: 1122-10-7

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.1122-10-7, name is 3,4-Dibromo-1H-pyrrole-2,5-dione. Here is a downstream synthesis route of the compound 1122-10-7. 1122-10-7

Ac-Arg-Arg-Arg-Arg-Cys-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys-Arg-Arg-Arg-Arg-NH2 (2 mg) was dissolved in Dulbecco’s phosphate buffered saline (5 mL, without Ca, Mg) and acetonitrile (5 mL). 3,4-dibromomaleimide (0.2 mg, 1 eq.) was added to the solution, and the mixture was stirred for 1 h at room temperature. To the resulting mixture was added H2O (10 mL) and the solution was filtered and applied to the preparative HPLC, and linear density gradient elution (60 min) was then performed with eluents A/B: 75:25-65:35 using eluent A: 0.1% TFA in water and eluent B: 0.1% TFA-containing acetonitrile on preparative HPLC using YMC-Actus Triart Prep C8-S S-10mum 20 nm column (30 ¡Á 250 mm); flow rate: 15 mL/min. The fractions containing the product were collected and lyophilized to give 1.6 mg of peptide 15 as a yellow powder; mass spectrum: (M + H)+ 2655.54 (calcd 2655.38). Elution time on RP-HPLC: 8.05 min. Elution conditions: YMC Triart C8 column (4.6 ¡Á 100 mm), linear density gradient elution with eluents A/B = 80/20-30/70 (25 min), using 0.1% TFA in water as eluent A and 0.1% TFA-containing acetonitrile as eluent B; flow rate: 1 mL/min., 1122-10-7

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1122-10-7

Reference£º
Article; Niida, Ayumu; Sasaki, Shigekazu; Yonemori, Kazuko; Sameshima, Tomoya; Yaguchi, Masahiro; Asami, Taiji; Sakamoto, Kotaro; Kamaura, Masahiro; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2757 – 2761;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: Dried pressure tube was charged with magnetic stir bar and50 mg of PdSiO2 catalysts (1 mol% with respect to amine). Then,1.0 mL o-xylene was added, followed by the addition of 0.5 mmolof amine and 1 mmol of benzyl alcohol. The pressure tube wasflushed with argon was closed with screw cap. Then it was placedin the preheated aluminum block and reaction was allowed to progressfor 30 h at 150 C. After completion of the reaction, pressuretube was removed from aluminum block and cooled down to roomtemperature. The catalyst was filtered out by ciliate and reactionproducts were analyzed by GC-MS and the corresponding amineswere purified by column chromatography. The yields of selectedamines were determined by GC analysis using n-hexadecane asstandard. For this purpose, after completion of the reaction, nhexadecane(100 mL) as standard was added to the reaction pressuretube and the reaction products were diluted with ethyl acetate followed by filtration using plug of silica and then subjected GCanalysis., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Alshammari, Ahmad S.; Natte, Kishore; Kalevaru, Narayana V.; Bagabas, Abdulaziz; Jagadeesh, Rajenahally V.; Journal of Catalysis; vol. 382; (2020); p. 141 – 149;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,3-dibromomaleimide (0.255 g, 1.0mmol) in tetrahydrofuran (4 ml) N-methylmorpholine (76 mul, 1.1mmol) and methyl chloroformate (85 mul, 1.1mmol) were added at 0 C. When TLC (nhexane:acetone=8:2) showed complete conversion of the starting material(3 h), the reaction mixture was diluted with CH2Cl2, filtered through a pad ofCelite and evaporated. The obtained crude 4 (0.308 g) was reacted, withoutpurification, with t-butyl mercaptan 2g (237 mul, 2.1mmol) according to generalmethod A to give compound 6g (0.150 g). The crude product was used forfurther step without purification.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 2,3-dibromo-N-isobutane-maleimide:Dissolve 200 mg of sodium hydride in 10 mL of N, N-dimethylformamide in an ice-water bath.Dissolve 600mg of 2,3-dibromomaleimide in 10mLN, N-dimethylformamide was added dropwise to sodium hydride,After stirring for 30min, 1-bromo-2-methylpropane was added, and the reaction was heated to 60 C for 1h.Quenched by saturated ammonium chloride after cooling,Ethyl acetate extraction, drying over anhydrous sodium sulfate, concentration, column chromatography403 mg of product was obtained., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Wang Ying; Wang Ruifang; Wang Pengfei; Liu Yanwei; Wei Xiaofang; Liu Jianjun; Li Zhiyi; Hu Xiaoxiao; (24 pag.)CN110551054; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1)., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dibromomaleimide 1a, 2.0 g (7.84 mmol), was dissolved in 15 mL of anhydrous DMF, and 0.9 mL (9.51 mmol) of 4-fluoroaniline and 2 mL (11.5 mmol) of DIPEA were added. The mixture was stirred for 24 h at 50C and poured into a mixture of water and ethyl acetate. The organic layer was separated, washed with dilute aqueous HCl, and evaporated under reduced pressure, and the residue was purified by column chromatography using petroleum ether-ethyl acetate (5 : 1) as eluent.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Panov; Simonov, A. Yu.; Korolev; Russian Journal of Organic Chemistry; vol. 55; 12; (2019); p. 1847 – 1852; Zh. Org. Khim.; vol. 55; 12; (2019); p. 1850 – 1856,7;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2,3-dibromomaleimide23 (1.0 mmol) in CH2Cl2 (20ml) Et3N (2.0mmol) and thiol (2.1mmol) were added under argon atmosphere and stirred for 3 h at room temperature. The reaction mixture was evaporated,and the crude product was purified by flash chromatography to give the desired compound., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1122-10-7

The 2,3-dibromomaleimide (2.55 g, 10.0 mmol) was placed in a 100 mL three-necked flask,Dissolved in 30 mL of dry DMF,Nitrogen protection, down to 0 C,Sodium hydride was added in two portions(480 mg, 12 mmol, 60% mass fraction in paraffin). After 1 h, 10 mL of dry DMF dissolved chloromethylbenzyl ether (2.08 mL, 15 mmol) was added,Rose to room temperature reaction 2h.After the drop to 0 C, adding 20 mL of saturated ammonium chloride solution to stop the reaction,Ethyl acetate, and the organic phase was dried over anhydrous sodium sulfate and concentrated.Column separation by petroleum column: Ethyl acetate = 50: 1 (v / v) eluting the compound4-benzyloxymethyl-2,3-dibromomaleimide 3.55 g, 94% yield.Magnesium wire (432 mg, 18.0 mmol) was placed in 100 mL dry three-necked flask,Add 4 mL of dry tetrahydrofuran, replace with argon,After the introduction of ethyl bromide (1.35 mL, 18.0 mmol)After reaction at room temperature for 15 min, the reaction was brought to 40 C for 30 min.The indole (2.11 g, 18.0 mmol) was introduced via a catheter for 1 h.Followed by the addition of N-benzyloxymethyl-2,3-dibromomaleimide (3.29 g, 8.9 mmol)Room temperature reaction 4h.The reaction was terminated by the addition of 20 mL of saturated ammonium chloride solution, extracted with ethyl acetate,The organic phase was dried over anhydrous sodium sulfate and concentrated. The column was separated by column chromatography,Petroleum ether: ethyl acetate = 4: 1 (v / v) to give 3.46 g of compound 185a in 94% yield.

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Ocean University of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; (142 pag.)CN106083830; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 2.5 g of 3,4-dibromo-1H-pyffole-2,5-dione (10 mmol) and 1 g of NMM in 60 mL of THF, MeOCOC1 (10 mmol, 940 mg in 10 ml DCM) was added dropwise, stuffed for 20 mm, then the reaction solution was diluted with 6o mL of DCM, washed 3 time by water, the organic phase was stirred by sodium sulfate anhydrous, concentrated, 2.65g of methyl 3,4-dibromo-2,5-dioxo-2H-pyrrole-1(5H)-carboxylate was obtained. To 311mg, 1 mmol of this compound, 2-(2-azidoethoxy)ethanamine (130 mg, 1 mmol) and 5 mL DCM was added, TLC shown the reaction finished in 20 mm, then extracted by DCM and brine, washed by NH4C1 solution, dried on sodium sulfate anhydrous, and then concentrated for column purification, flashed by 2:1 hexane and ethyl ethylate, 230 mg of 1-(2-(2-azidoethoxy)ethyl)-3,4-dibromo-1H-pyffole-2,5-dione obtained. 1HNMR: 3.32 ppm (t, J = 5.0 Hz, 1H), 3.40 ppm (t, J = 5.0Hz, 1H), 3.50 ppm (q, J =5.0 Hz, 1H), 3.62 ppm (t, J = 5.0 Hz, 1H), 3.63-3.69 ppm (m, 3H),3.84 ppm (t, J = 5 hz, 1H). Fw: 365.9, C8H8Br2N4O3 Mass Peaks (1:2:1): 366.9, 368.9,370.9.

1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SORRENTO THERAPEUTICS, INC.; FU, Yanwen; KAUFMANN, Gunnar, F.; JONES, Bryan; TOUGHIRI, Raheleh; (82 pag.)WO2015/175357; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,4-dibromo-N-methyl ester maleimide was synthetized from the corresponding 3,4-dibromomaleimide by adapting the procedure disclosed by Castaeda et al. in Tetrahedron Lett. 2013, 54, 3493-3495.3,4-dibromomaleimide (5 g, 19.92 mmol) was dissolved in THE (175 ml). N-methylmorpholine (2.16 ml, 19.92 mmol) and methyl chloroformate (1.51 ml, 19.92 mmol) were added at room temperature under argon. The reaction mixture was stirred at room temperature under argon for 20 mm, then diluted with DCM (200 ml). The organic layer was washed with water (200 ml), dried over MgSO4, concentrated and lyophilized to yield 6.15 g (100%) of product.[00252] 1H NMR (500 MHz, CDCI3): 5= 4.01 (5, 3H). 130 NMR (126 MHz, CDCI3): 5= 159.23, 146.91, 131.41, 54.79., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; HEIDELBERG PHARMA RESEARCH GMBH; GALLO, Francesca; KORSAK, Barbara; MUELLER, Christoph; HECHLER, Thorsten; PAHL, Andreas; KULKE, Michael; SIMON, Werner; LUTZ, Christian; (163 pag.)WO2019/57964; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem