Category: 1122-10-7

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 19 Preparation of 3,4-Bis-phenylsulfanyl-pyrrole-2,5-dione To dibromomaleimide (80.0 mg, 0.3 mmol) and sodium hydrogencarbonate (130.2 mg, 1.6 mmol) in methanol (6 ml) was slowly added benzenethiol (66.6 mul, 0.7 mmol) in methanol (1 ml). The reaction was stirred for 15 min at RT. The solvent was removed in vacuo and the residual material was purified by flash chromatography on silica gel (petroleum ether: ethyl acetate, gradient elution from 9:1 to 7:3) to afford the desired product as bright yellow crystals (73 mg, 75%). lambdamax (50 mM sodium phosphate, pH 6.2, 40% MeCN, 2.5% DMF)/412 nm (epsilon/dm3 mol-1 cm-1 2245); 1H NMR (500 MHz, MeOD): delta=7.27-7.22 (m, 6H, Ar-H), 7.16-7.14 (m, 4H, Ar-H); 13C NMR (125 MHz, MeOD): delta=169.3 (C), 137.6 (C), 135.4 (C), 132.4 (CH), 130.1 (CH), 129.1 (CH); IR (solid, cm-1): 3285 (m), 3059 (w), 2924 (w), 1774 (m), 1715 (s); MS (CI) m/z, (%): 314 (M+H, 100), 206 (13), 111 (12); Mass calc. for C16H11O2NS2[H]: 314.0231. Found: 314.0309; m.p. 102-104 C. (Literature: 123-126 C.)., 1122-10-7

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; UCL Business Plc; Smith, Mark; Caddick, Stephen; Baker, James; Chudasama, Vijay; (80 pag.)US9295729; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-methoxycarbonyl-dibromomaleimide (4)0::xcTo a solution of dibromomaleimide (1.00 g, 3.9 mmol) and N-methylmorpholine (0.433 mL, 3.9 mmol) in THF (35 mL) was added methylchloroformate (0.304 mL, 3.9 mmol) and the mixture was stirred for 20 mm. at room temperature. Then CH2C12 (40 mL) was added, the organic phase was washed with H20, dried over MgSO4 and the solvent removed in vacuo to yield the desired product as a pink powder (1.18 g, 3.8 mmol, 97%).m.p. 115-118C; Vmax (cm?) 3236, 2962, 1809, 1769, 1730, 1602; oH (CDC13, 500MHz)4.00 (3H, s, CH3); Oc (CDC13, 125 IVIHz) 159.3, 147.0, 131.5, 54.9; MS (CI) m/z (%)314 (MPH, 100), 206 (13), 111(12); Mass calculated for C6H3O4N79Br2: 310.8423,observed: 310.8427., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; SMITH, Mark Edward Brennan; WO2013/121175; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: In a 100 mL dry one-neck round bottom flask equipped with a magnetic stir bar, 3,4-dibromomaleimide (1.00 equiv) was added under N2 atmosphere. Acetone (0.62 M) and K2CO3 (1.10 equiv) were successively added and vigorously stirred for 10 min. Then, the corresponding alkylating reagent (1.20-1.40 equiv) was added to one portion. The reaction was stirred during the overnight period and quenched by solvent evaporation and extraction with AcOEt (3 x 20 mL). The crude sample from the reaction was purified by column chromatography. The spectroscopic data match perfectly with those previously described.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Mendoza-Macias, Claudia Leticia; Solorio-Alvarado, Cesar Rogelio; Alonso-Castro, Angel Josabad; Alba-Betancourt, Clara; Deveze-Alvarez, Martha Alicia; Padilla-Vaca, Felipe; Reyes-Gualito, Arturo; Chemical Papers; vol. 74; 5; (2020); p. 1429 – 1438;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1122-10-7, In a 50 mL two-necked flask,A mixture of NaH (30 mg, 0.75 mmol, 60% by mass, dispersed in paraffin) was suspended in 5 mL of DMF, and 5 mL of DMF dissolved in 2,3-dibromomaleimide (127.5 mg, 0.5Mmol) and low temperature reaction for 30 min,(47muL, 0.75mmol), low temperature reaction 30min, dropping saturated NH4Cl solution to terminate the reaction, CH2Cl2 extraction, organic layer evaporated, silica gel column chromatography,Petroleum ether: ethyl acetate = 30: 1 (v / v) to give 92 mg of white crystals (82a) in 69% yield.

As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Patent; Ocean University of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences; Zhu, Weiming; Ma, Hongguang; Wang, Liping; Xu, Zhihong; Zhang, Yapeng; Wang, Yi; Liu, Peipei; (142 pag.)CN106083830; (2016); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

511 mg (1.95 mmol) of triphenylphosphine was dissolved in 5 mL of anhydrous THF and stirred.0.38 mL (1.95 mmol) of azoxylene diisopropyl ester was added dropwise to the above solution, and stirred at -78 C for 5 min.After 0.25 mL (1.56 mmol) of triethylene glycol monomethyl ether was dissolved in 5 mL of anhydrous THF, the reaction mixture was added dropwise to the azoazolyl diisopropyl ester solution, and stirring was continued at -78 C for 5 min.Thereafter, neopentyl alcohol 121 mg (1.37 mmol) was dissolved in 2 mL of anhydrous THF, added to triethylene glycol monomethyl ether, and stirred at -78 C for 5 min.Finally, 497 mg (1.95 mmol) of dibromomaleimide was added to the above reaction solution, stirred at -78 C for 10 min, then transferred to room temperature, and magnetically stirred at room temperature for 20 h.The crude product was purified by column chromatography (volume ratio EA_PA=1:10-1:4), and then isolated by medium pressure to obtain the white target product, intermediate 1 325 mg, yield 52.2%.

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Henan Normal University; Jiang Tao; Wang Zhiying; Wang Jie; Chi Yanwei; Dong Wenpei; Zhang Yue; Xin Pengyang; Chen Changpo; (11 pag.)CN109293683; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 18 Preparation of 3,4-Bis-(2-hydroxy-ethylsulfanyl)-pyrrole-2,5-dione To 2-mercaptoethanol (683.8 mul, 9.8 mmol) in buffer (100 ml, 150 mM NaCl, 100 mM sodium phosphate, pH 8.0, 5.0% DMF) was added di-bromomaleimide (1 g, 3.9 mmol) in DMF (2.5 ml, final concentration DMF 7.5%). The reaction was stirred for 30 min at RT and lithium chloride (20 g) was added. The aqueous reaction mixture was extracted with ethyl acetate (7*150 ml). The organic layers were combined, the solvent removed in vacuo and the residual material was purified by flash chromatography on silica gel (petroleum ether:ethyl acetate, gradient elution from 1:1 to 1:9). Fractions containing the product were collected and the solvent were removed in vacuo. The still impure product was purified by flash chromatography on silica gel (methanol:dichloromethane, gradient elution from 0.5-10.0% methanol) to afford the desired compound as a yellow solid (518 mg, 53%). lambdamax (50 mM sodium phosphate, pH 6.2, 40% MeCN, 2.5% DMF)/318 nm (epsilon/dm3 mol-1 cm-1 1855); 1H NMR (500 MHz, MeOD): delta=3.74 (t, 4H, J=6.4, 2*HO-CH2), 3.41 (t, 4H, J=6.3, 2*S-CH2) 13C NMR (125 MHz, MeOD): delta=168.5 (C), 137.2 (C), 62.3 (CH2), 34.4 (CH2); IR (solid, cm-1): 3344 (s), 2500 (m), 2078 (w); MS (EI) m/z, (%): 250 (M, 43), 232 (100), 161 (37); Mass calc. for C8H11O4NS2: 250.02077. Found: 250.02126; m.p. 46-50 C.

1122-10-7, The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCL Business Plc; Smith, Mark; Caddick, Stephen; Baker, James; Chudasama, Vijay; (80 pag.)US9295729; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (Indolin-3-yl)ethanole 2a (1.700 g, 10.4 mmol) and Et(iPr)2N(3.5 mL, 20 mmol) were added to solution of 3,4-dibrommalemide 1 (2.540 g, 10 mmol) in dry DMF (5 mL). The reaction mixture was left to stir overnight at 50 C. The cooled to rt reaction mixture was diluted with EtOAc (100 mL), washed with water (200 mL), brine (50 mL), dried, and evaporated. The residue was chromatographed (33.3% EtOAc/petroleum ether) to give 4a as a red amorphous solid (2.642 g, 7.8 mmol, 80%), 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various.

Reference£º
Article; Simonov, Alexander Y.; Bykov, Evgeny E.; Lakatosh, Sergey A.; Luzikov, Yury N.; Korolev, Alexander M.; Reznikova, Marina I.; Preobrazhenskaya, Maria N.; Tetrahedron; vol. 70; 3; (2014); p. 625 – 630;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0059] Example 2 – Synthesis of 39-(3,4-dibromo-2,5-dioxopyrrolyl)- 3, 6,9, 12, 15, 18,21, 24,27, 30,33, 36-dodecaoxanonatriacontanoic acid: [0060] A 100 mL two-necked round bottom flask was flame dried and cooled under nitrogen. The cooled flask was charged with 200 mg (0.296 mmol) of ieri-butyl 39-hydroxy- 3, 6, 9, 12,15, 18,21, 24,27, 30,33, 36-dodecaoxanonatriacontanoate. Triphenylphosphine, 106 mg, was dissolved in about 5 mL anhydrous tetrahydrofuran in a vial, and the solution was added to thelOO mL flask via cannula under nitrogen. The 100 mL flask was cooled in an ice-water bath for 15 minutes. To the cooled solution was added 55 mg (0.217mmol) 3,4-dibromopyrrole-2,5-dione with stirring until a clear solution was observed. DIAD, 58.3 muL¡¤, was added to the cooled reaction mixture, which was stirred in the ice bath for an additional 10 minutes. The reaction mixture was stirred and allowed to reach room temperature over about 20 hours, then concentrated on a rotary evaporator until dry, giving a yellow viscous oil, which was absorbed onto about 1 g silica gel and dry-loaded onto a Reveleris normal phase chromatography unit. The oil was eluted over a 12 g silica gel cartridge with a methanokdichloromethane gradient from 1:0 to 9:1 over 28 column volumes. The fractions containing the desired product were pooled and concentrated to dryness. The purified product was suspended in 50:50 acetonitrile: water and lyophilized overnight to provide a clear light yellow viscous oil. By LC-MS analysis, the of ieri-butyl-protected carboxylic acid product had been partially deprotected during the work-up. To fully deprotect the material to the free acid, the lyophilized material was treated with 5% trifluoroacetic acid in dichloromethane, concentrated to dryness and lyophilized in acetonitrile: water (50:50) overnight., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; IGENICA, INC.; JACKSON, David, Y.; HA, Edward; WO2013/85925; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem