Category: 1977-07-7

New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, belongs to pyrrolines compound, is a common compound. In a patnet, author is Li, Zhenghua, once mentioned the new application about 1977-07-7, HPLC of Formula: https://www.ambeed.com/products/1977-07-7.html.

Enantioselective Cyanoborylation of Allenes by N-Heterocyclic Carbene-Copper Catalysts

The simultaneous incorporation of both a cyano group and a boryl unit into the C=C double bonds of allenes in a regio- and stereoselective fashion is of much interest and importance but remains a significant challenge. We report herein a copper-catalyzed chemo-, regio-, and enantioselective cyanoborylation of allenes, which afforded a family of valuable enantiopure beta-boryl allyl nitriles. The high enantioselectivity was achieved by installing of appropriate substituents at the C2 and C6 positions of the naphthyl groups in our newly synthesized N-heterocyclic carbene (NHC) ligands. The reaction mechanism has been clarified by some stoichiometric reactions and computational studies. This work provides an inspiring example of the development of selective catalytic reactions for the synthesis of functional molecules through fine-tuning the ligands in catalysis.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New Advances in Chemical Research in 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage , causing turnover rates to depend strongly on interfacial structure. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is , belongs to pyrrolines compound. In a document, author is Castillo, MA, Formula: https://www.ambeed.com/products/1977-07-7.html.

Insecticidal, anti-juvenile hormone, and fungicidal activities of organic extracts from different Penicillium species and their isolated active components

Organic extracts from mycelium and culture broth of 21 Penicillium isolates have been tested for insecticidal, insect anti-juvenile hormone (anti-JH), and antifungal activities. Culture broth extracts were the most active, mainly against insects; nearly 25% of them have shown high entomotoxicity (100% mortality at 100 mu g/cm(2)). A strong in vivo anti-JH activity against Oncopeltus fasciatus Dallas was detected in the culture broth extracts from P. brevicompactum P79 and P88 isolates. The two new natural products isolated from P79, N-(2-methyl-3-oxodec-8-enoyl)-2-pyrrolin (1) and 2-hept-5-enyl-3-methyl-4-oxo-6,7,8, 8a-tetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (2), possessed anti-SN and insecticidal activity, respectively, against O. fasciatus. Synthesized natural compound 1 has-shown an ED50 of 0.7 mu g/nymph when assayed on newly molted fourth-instar nymphs of O. fasciatus. Promising biological activities have also been detected in the synthetic precursors.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New Advances in Chemical Research, May 2021.Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, belongs to pyrrolines compound, is a common compound. In a patnet, author is Smith, AB, once mentioned the new application about 1977-07-7, Product Details of 1977-07-7.

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors

The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with improved cellular transport properties relative to the earlier inhibitors based on bispyrrolinones and their peptide counterparts. The most potent inhibitor (-)-7 displayed 13% oral bioavailability in dogs. X-ray structure analysis of the monopyrrolinone compounds cocrystallized with the wild-type HIV-1 protease provided valuable information on the interactions between the inhibitors and the HIV-1 enzyme. In each case, the inhibitors assumed similar orientations for the P2′-P1 substituents, along with an unexpected hydrogen bond of the pyrrolinone NH with Asp225. Interactions with the S2 pocket, however, were not optimal, as illustrated by the inclusion of a water molecule in two of the three inhibitor-enzyme complexes. Efforts to increase affinity by displacing the water molecule with second and third generation inhibitors did not prove successful. Lack of success with this venture is a testament to the difficulty of accurately predicting the many variables that influence and build binding affinity. Comparison of the inhibitor positions in three complexes with that of Indinavir revealed displacements of the protease backbones in the enzyme flap region, accompanied by variations in hydrogen bonding to accommodate the monopyrrolinone ring. The binding orientation of the pyrrolinone-based inhibitors may explain their sustained efficacy against mutant strains of the HIV-1 protease enzyme as compared to Indinavir.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

New research progress on 1977-07-7 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, belongs to pyrrolines compound, is a common compound. In a patnet, author is Xu, Junwen, once mentioned the new application about 1977-07-7, Recommanded Product: 1977-07-7.

Thiol-functionalized PIM-1 for removal and sensing for mercury (II)

Polymers of intrinsic microporosity (PIMs) are a class of microporous polymers with rigid and contorted molecular structures. The special structures lead to incomplete space occupation, and the pores of PIMs originate from the formed void. In this work, we made attempts to expand the applications of PIMs to the aspect of heavy metal removal. First, PIM-1 was synthesized using tetrafluoroterephthalonitrile (TFTPN) and 5,5′,6,6′-tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobisindane (TTSBI) as precursors. The primary PIM-1 was quite hydrophobic, and thus could not be evenly dispersed in water, resulting in low adsorption capacity for mercury ions (Hg2+). A conversion of nitrile group in PIM-1 to thiol group was then carried out by two steps, namely carboxylation and introduction of thiol groups. The carboxylation made the polymers more active, and the final thiol-functionalization provided the polymers with hydrophilicity and affinity for Hg2+. The thiolethyl modified PIM-1 (assigned as PIM-G) and thiophenyl modified (assigned as PIM-B) possessed maximum Hg2+ adsorption capacity of 136 mg g(-1) and 127 mg g(-1) at pH 5, respectively. Besides, the thiol-functionalized PIMs had fluorescence property and showed potential in sensing for Hg2+.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Research speed reading in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4. In an article, author is Gein, V. L.,once mentioned of 1977-07-7, Application In Synthesis of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine.

Synthesis and antibacterial activity of 5-aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones

5-Aryl-4-acyl-3-hydroxy-1-(2-hydroxyethyl)-3-pyrrolin-2-ones were synthesized using the reaction of ethanolamine with a mixture of aromatic aldehyde and methyl acylpyruvates. The antibacterial activity of the synthesized compounds was studied.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemical Research Letters, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. Formula: https://www.ambeed.com/products/1977-07-7.html,1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, SMILES is CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1, belongs to pyrrolines compound. In a document, author is Ricko, Sebastijan, introduce the new discover.

Insights on the Pseudo-Enantiomeric Properties of Bifunctional Cinchona Alkaloid Squaramide-Derived Organocatalyst

The use of pseudo enantiomers is a well-known method of achieving products of complementary stereochemistry. Only rarely can different enantiomers of a product be accessed without modulation of the catalyst. Recently, a system was reported wherein two different enantiomers of spirocycles were obtained by a cascade reaction of unsaturated pyrrolin-4-ones with mercaptoacetaldehyde catalyzed by a single optimized cinchona alkaloid squaramide-derived organocatalyst. It was originally proposed that the E/Z geometry of the unsaturated pyrrolin-4-one dictated the stereochemistry of the spirocycle product, but this was not investigated further. In the present work, we have investigated the nature of a pseudo-enantiomeric organocatalyst conformation applying density functional theory calculations for investigating the transition states for the reaction. Furthermore, the influence of the double-bond geometry of the pyrrolin-4-one has been studied beyond what is possible to test experimentally. The results provide a greater understanding for this class of reactions that may be applicable in future methodology development.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine. In a document, author is Gao, Yang, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/1977-07-7.html.

Road performance of liquid nitrile-butadiene rubber modified unsaturated polyester resin concrete

Unsaturated polyester resin concrete (UPC) is currently gaining attention in many fields due to its functional compressive capacity and corrosion resistance. However, the toughness of UPC is poor due to the weak resistance to the deformation of the cured unsaturated polyester resin (UP). In this paper, the UP was modified with liquid nitrile-butadiene rubber (LNBR) and further used to make concrete. At the same time, two different initiators were used to cure the UPC and LNBR modified UPC. To study the mechanism and road performance of LNBR modified UPC performance, optical microscopy test, Marshall test, water immersion Marshall test, rutting test, freeze-thaw split test, and infrared spectroscopy experiments were carried out. Test results showed that LNBR could effectively improve the low-temperature toughness of UPC. Although LNBR slightly reduced the Marshall stability and rutting resistance of UPC, it hardly changed the water stability of the UPC. LNBR could crosslink with UP to form a joint body, and the amount of initiator may have a more significant impact on the performance of the UPC and LNBR modified UPC. (C) 2020 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1977-07-7 help many people in the next few years. COA of Formula: https://www.ambeed.com/products/1977-07-7.html.

Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ricko, Sebastijan, once mentioned the application of 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, molecular weight is 292.3782, MDL number is MFCD01730958, category is pyrrolines. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/1977-07-7.html.

Insights on the Pseudo-Enantiomeric Properties of Bifunctional Cinchona Alkaloid Squaramide-Derived Organocatalyst

The use of pseudo enantiomers is a well-known method of achieving products of complementary stereochemistry. Only rarely can different enantiomers of a product be accessed without modulation of the catalyst. Recently, a system was reported wherein two different enantiomers of spirocycles were obtained by a cascade reaction of unsaturated pyrrolin-4-ones with mercaptoacetaldehyde catalyzed by a single optimized cinchona alkaloid squaramide-derived organocatalyst. It was originally proposed that the E/Z geometry of the unsaturated pyrrolin-4-one dictated the stereochemistry of the spirocycle product, but this was not investigated further. In the present work, we have investigated the nature of a pseudo-enantiomeric organocatalyst conformation applying density functional theory calculations for investigating the transition states for the reaction. Furthermore, the influence of the double-bond geometry of the pyrrolin-4-one has been studied beyond what is possible to test experimentally. The results provide a greater understanding for this class of reactions that may be applicable in future methodology development.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

Reference of 1977-07-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1977-07-7, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, SMILES is CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1, belongs to pyrrolines compound. In a article, author is Lorenz, Peter, introduce new discover of the category.

Chemistry of Hermidin: Insights from Extraction Experiments with the Main Alkaloid of Mercurialis perennis L. Tracked by GC/MS and LC/MSn

Hermidin (1), a piperidine-2,3-dione alkaloid, has been previously detected as a lipophilic constituent in Mercurialis perennis L. and other Mercurialis species. Because of strong electron-withdrawing effects of its carbonyl groups, an acidic H-atom is easily subtracted from 1, whereas the latter shows high reactivity towards oxidation reactions or the attack of C-nucleophilic agents. To obtain a better understanding of possible chemical pathways upon extraction of root parts of M. perennis, the products obtained with different solvents from 1 were investigated. Extraction of M. perennis with aqueous MeOH or EtOH yielded a mixture of hermidin quinone (3), 5-hydroxy-4-methoxy-5-(alkoxycarbonyl)-1-methyl-3-pyrrolin-2-ones, 7 and 8, and d, l- and meso-isochrysohermidins, 5 and 6, all of them being investigated by GC/MS and LC/MSn. The latter compounds were supposedly formed by free-radical reactions, followed by spontaneous benzilic acid rearrangement and esterification. Furthermore, extraction of M. perennis with aqueous Me2CO produced an aldol condensation product, the known alkaloid speranskatine A (9a), which was identified by NMR after chromatographic purification. In a similar manner, a CH2 homolog of speranskatine A (10a) was obtained as a novel compound when ethyl methyl ketone (= butan-2-one; EtCOMe) instead of Me2CO was used for extraction. Consequently, 1 easily undergoes artefact formation upon extraction of plant material with polar or slightly polar solvents.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem

In an article, author is Roder, Anja, once mentioned the application of 1977-07-7, HPLC of Formula: C18H20N4, Name is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula is C18H20N4, molecular weight is 292.3782, MDL number is MFCD01730958, category is pyrrolines. Now introduce a scientific discovery about this category.

Vacuum-Ultraviolet Absorption Spectrum of 3-Methoxyacrylonitrile

The high-resolution absorption spectrum of 3-methoxyacrylonitrile (3MAN) was measured between 5.27 and 12.59 eV using a synchrotron-based Fourier-transform spectrometer. It was related to an absolute absorption cross-section scale. Complementary calculations at the DFT-MRCl/aug-cc-pVTZ level of theory document the vertical transition energies and oscillator strengths toward the first 19 states of both the E and Z geometrical isomers of 3MAN. Comparisons with the experimental absorption spectrum reveal the similarities and differences between 3MAN, a bifunctional molecule, with acrylonitrile and methyl-vinylether, where only one functional group is present. As in acrylonitrile, several broad valence transitions were observed up to the ionization limit. They are likely associated with the extended pi-system induced by the nitrile group but might also involve sigma sigma* transitions close to the ionization limit. As in methylvinylether, Rydberg series converging to the ionization limit are absent. This is attributed to a difference in neutral and cationic geometry due to a 60 degrees rotation of the methyl group.

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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem