Synthetic Route of 272786-64-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 272786-64-8, Name is 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, SMILES is O=C1CCC2CN(S(=O)(C3=CC=C(F)C=C3)=O)CCN21, belongs to pyrrolines compound. In a article, author is Api, A. M., introduce new discover of the category.
RIFM fragrance ingredient safety assessment, 2-benzyl-2-methylbut-3-ene-nitrile, CAS Registry Number 97384-48-0
The existing information supports the use of this material as described in this safety assessment. 2-Benzyl-2-methylbut-3-enenitrile was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-benzyl-2-methylbut-3-enenitrile is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-benzyl-2-methylbut-3-enenitrile is below the ITC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data show that there are no safety concerns for 2-benzyl-2-methylbut-3-enenitrile for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 2-benzyl-2-methylbut-3-enenitrile is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 2-benzyl-2-methylbut-3-enenitrile was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1. Synthetic Route of 272786-64-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 272786-64-8 is helpful to your research.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem