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N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa

This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compositions containing said derivatives, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Properties and Exciting Facts About 5264-35-7

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 5-Methoxy-3,4-dihydro-2H-pyrrole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO

HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Simple exploration of 5-Methoxy-3,4-dihydro-2H-pyrrole

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5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, belongs to pyrrolines compound, is a common compound. 5264-35-7In an article, authors is Anderskewitz, Ralf, once mentioned the new application about 5264-35-7.

Pyrrolidinohydroquinazolines – A novel class of CCR3 modulators

A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly proved to be an agonist.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Discovery of 5-Methoxy-3,4-dihydro-2H-pyrrole

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5264-35-7, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 5264-35-7

PYRROLIDINOHYDROCHINAZOLINES

The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Discovery of 5264-35-7

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, molecular formula is C5H9NO, 5264-35-7. In a Article, authors is Srairi, Driss£¬once mentioned of 5264-35-7

Hydroxylations microbiologiques de pyrrolidinones-2 (note de laboratoire)

Microbial hydroxylations of various pyrrolidin-2 ones, especially N-acylated, with Beauveria sulfurescens have been carried out.The regioselectivity depends on the nature of the substituent on the nitrogen atom and the hydroxylation may occur at position 3,4 or 5 of the heterocycle.Hydroxylations at position 3 or 4 occur with low enantioselectivity.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

The important role of 5264-35-7

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NEW APPROACHES TO THE SYNTHESIS OF SPERMINE AND SPERMIDINE ALKALOIDS

New approaches to the formation of macrocyclic lactams are described involving successive ring expansion of 8-lactams and other heterocyclic systems.These methods have been used in the synthesis of a number of spermine and spermidine alkaloids including homaline, celacinnine, dihydroperiphylline, chaenorhine and verbascenine.

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Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Properties and Exciting Facts About

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The reaction of lactim ethers 1-3 with organolithium reagents has been found to be an effective method for the preparation of cyclic 2-alkyl imines 4-6.The method is most effective for the preparation of 2-aryl and sterically hindered 2-alkyl imines.In addition, treatment of 1-3 with excess organolithium provides a facile route to the rare cyclic 2,2-dialkyl amine derivatives 7-9.These reactions are characterized by mild reaction conditions and good yields and constitute a superior route to the title compounds.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

New explortion of

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Substituted 2-amino-4(1H)pyridones are provided which are renal vasodilators and bronchodilators.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

More research is needed about

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As reported by Scheidt and Bode in 2005, sterically nonencumbered alpha,beta-enals are readily converted to saturated esters in the presence of alcohols and N-heterocyclic carbene catalysts, e.g., benzimidazolylidenes or triazolylidenes. However, substituents at the alpha- or beta-position of the alpha,beta-enal substrate are typically not tolerated, thus severely limiting the substrate spectrum. On the basis of our earlier mechanistic studies, a set of N-Mes- or N-Dipp-substituted 1,2,4-triazolium salts were synthesized and evaluated as (pre)catalysts in the redox esterification of various alpha- or beta-substituted enals. In particular the 1,4-bis-Mes/Dipp-1,2,4-triazolylidenes overcome the above limitations and efficiently catalyze the redox esterification of a whole series of alpha/beta-substituted enals hitherto not amenable to NHC-catalyzed transformations. The synthetic value of 1,4-bis-Mes/Dipp-1,2,4-triazolylidenes is further demonstrated by the one-step bicyclization of 10-oxocitral to (racemic) nepetalactone in diastereomerically pure form.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem

Discovery of

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3-(Piperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole was synthesized through a four-step process including etherification, hydrazonation, cyclization, and reduction with an overall yield of 39%. The final product was characterized by 1H NMR and ESI-MS/MS. The molecular structures of benzyl (Z)-4-(2-(pyrrolidin-2-ylidene)hydrazine-1-carbonyl)piperidine-1-carboxylate and related compounds were analyzed using DFT calculations at the B3LYP/6-311+G(d,p) level of theory. The results indicated a higher stability of the hydrazone tautomers.

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem