Category: 5264-35-7

5264-35-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. Here is a downstream synthesis route of the compound 5264-35-7

5264-35-7, EXAMPLE I 5-Amino-2,3-dihydro-1H-indolizin-7-one Monohydrochloride To a solution of lithium diisopropylamide (LDA), prepared from n-BuLi (125 ml, 0.2M) and diisopropylamine (20.24 g, 0.2M), in dry THF (200 ml) was added under N2 at -10¡ã C. 5-methylisoxazole (8.31 g, 0.1 M). The resultant yellow suspension was stirred at -10¡ã C. for 1 hr before 1-aza-2- methoxy-1-cyclopentene (9.9 g, 0.1M) was added dropwise. A light yellow precipitate was immediately formed. The mixture was allowed to warm to ambient over a period of 19 hr. MeOH (100 ml) was slowly added with external cooling so that the internal temperature remained at 25¡ã-26¡ã C. The resulting reddish solution was then stirred at ambient for 24 hr and evaporated in vacuo. Flash column chromatography (30percent MeOH in CH2 Cl2 on silica gel, Em-60) followed by recrystallization (MeOH/Et2 O) gave the desired free base (3 g, 20percent); mp> 230¡ã C. It was then transformed into its HCl salt in MeOH with conc HCl. The salt was further recrystallized from MeOH/Et2 O to yield the title compound; mp>250¡ã C. yield 3 g, 81percent); TLC (30percent MeOH in CH2 Cl2); Rf=0.37; IR (KBr) cm-1, 3500, 3140, 1670, 1590. Anal. Calcd for C8 H10 N2 O. HCl: C, 51.48; H, 5.94; N, 15.01. Found: C, 51.08; H, 5.77; N, 14.89.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5264-35-7

Reference£º
Patent; Ortho Pharmaceutical Corporation; US4602013; (1986); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route.

5264-35-7, To 1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethanamine (258 mg, 0.97 mmol) in methanol (5 mL) was added 5-methoxy-3,4-dihydro-2H-pyrrole (96 mg, 0.97 mmol) followed by acetic acid (2 drops). The mixture was heated at 70¡ã C. for 16 hours. The mixture was cooled to room temperature and methanol was removed. Purification by chromatography on silica gel (5percent 7N NH3 in MeOH/CH2Cl2) gave N-(1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethyl)-3,4-dihydro-2H-pyrrol-5-amine (161 mg, 50percent) as an off white solid.1H NMR (300 MHz, CD3OD) delta 1.79-1.90 (m, 2H), 2.41-2.49 (m, 2H), 2.87-2.94 (m, 1H), 3.14-3.21 (m, 1H), 3.34-3.41 (m, 2H), 5.28-5.33 (m, 1H), 7.30-7.47 (m, 4H), 7.77-7.81 (m, 1H), 8.36-8.42 (m, 1H), 8.43 (s, 1H).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; ALLERGAN, INC.; US2010/145061; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route., 5264-35-7

5264-35-7, General procedure: A suspension containing 2,5-dimethyl-1H-pyrrole-3-carbohydrazide (2) (150 mg, 0.979 mmol,1.0 equiv.) and the appropriate methyl lactim (1.96 mmol, 2.0 equiv.) in toluene (2.00 mL, 0.5M) was heated in the microwave reactor at 180 ¡ãC for 1.0 h. The reaction mixture was allowedto cool to room temperature and was then concentrated under diminished pressure. The obtained15residue was applied to a silica gel column (50 g); eluting with 95:5 ? 75:25 DCM-MeOH(containing 10percent NH4OH) afforded the expected triazole.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5-Methoxy-3,4-dihydro-2H-pyrrole

Reference£º
Article; Duveau, Damien Y.; Yasgar, Adam; Wang, Yuhong; Hu, Xin; Kouznetsova, Jennifer; Brimacombe, Kyle R.; Jadhav, Ajit; Simeonov, Anton; Thomas, Craig J.; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 630 – 635;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, introduce a new downstream synthesis route., 5264-35-7

To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1 .98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 1 10 (M+H). 1 H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1 H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5264-35-7. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CHALTIN, Patrick; CHRIST, Frauke; DEBYSER, Zeger; DE MAEYER, Marc; MARCHAND, Arnaud; MARCHAND, Damien; VOET, Arnout; WO2012/65963; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. Here is a downstream synthesis route of the compound 5264-35-7

5264-35-7, Step 1 To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1.98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 110 (M+H). 1H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Katholieke Universiteit Leuven; Chaltin, Patrick; Christ, Frauke; Debyser, Zeger; De Maeyer, Marc; Marchand, Arnaud; Marchand, Damien; Voet, Arnout; US2013/245049; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. An updated downstream synthesis route of 5264-35-7 as follows.

5-methoxy-3,4-dihydro-2H-pyrrole (0.3 mL) was added to the solution of 5-propyl-8- [(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole tetraTFA salt (110 mg, 138 mg) in methanol (1 mL) at room temperature. The EPO mixture was stirred at room temperature overnight and purified by preparative HPLC (10-70percent CH3CN) to afford the title compound as its TFA salt (31mg). MS (M+l): 407.1. 1H NMR (400 MHz, CD3OD) delta ppm 0.91 (t, J=7.42 Hz, 3 H), 0.99 (d, J=6.44 Hz, 3 H), 1.06 – 1.28 (m, 2 H), 1.55 – 1.89 (m, 5 H), 2.14 – 2.39 (m, 2 H), 2.89 (s, 1 H), 3.00 – 3.21 (m, 4 H), 3.67 – 3.92 (m, 3 H), 3.94 – 4.06 (m, 2 H), 4.08 – 4.18 (m, 2 H), 4.60 (s, 1 H), 4.79 – 4.89 (m, 2 H), 7.17 – 7.27 (m, 1 H), 7.41 – 7.60 (m, 2 H)., 5264-35-7

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 5-Methoxy-3,4-dihydro-2H-pyrrole, you can also browse my other articles.

Reference£º
Patent; AstraZeneca AB; WO2006/101434; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 144; 5-Methoxy-3,4-dihydro-2H-pyrrole and triethylamine were added to ethyl 3-oxo-3-(2, 4,5-trifluorophenyl)propanoate, for stirring at 60¡ãC for 4 days, to obtain ethyl 3-oxo-2-pyrrolidin-2-ylidene-3-(2,4,5-trifluorophenyl)propanoate., 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astellas Pharma Inc.; EP1650192; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-pyrrolidinone was combined with dimethylsulphate in benzene and refluxed for 3 h. After purification including distillation, the resulting 2-methylimino ester pyrrolidine was combined with excess lithium phenoxide (PhLi) in dry ether at room temperature for 18 h to yield the title compound.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Benkovic, Stephen J.; Shapiro, Lucy; Wright, Rachel; Stephens, Craig; Kahng, Lyn Sue; Berdis, Anthony; Lee, Irene; US2005/227933; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

The reaction mixture comprising 1 mmol of 1-[N-(5,5-dimethyl-3,4,5,6-tetrahydropyrimidinium-2-yl)amino]dodecane-12-ammonium ditrifluoroacetate, 1 mmol (1 eq.) of 3,4-dihydro-5-methoxy-2H-pyrrole and 0.5 ml of triethylamine in 10 ml of absolute ethanol is heated under reflux for 20 hours. After cooling down to ambient temperature, the reaction mixture is evaporated to dryness and chromatographed on a silica column (CH2Cl2/CH3OH/NH4OH 85:13:2) in order to produce the product, in the form of an oil, with a yield of 65percent. NMR 1H (CD3OD, 360 MHz), delta (ppm): 1.12 (s, 6H); 1.36 (m, 16H); 1.60 (n, 2H); 1.69 (m, 2H); 2.28 (m, 2H); 2.93 (m, 2H); 3.09 (s, 4H); 3.22 (m, 2H); 3.31 (m, 2H); 3.75 (m, 2H). MS-ES+: [M+H]+: 378; [M+H+TFA]+: 492; [M+2H]++/2: 189.5

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2005/176819; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

3. 2-diphenylpyrrole (Compound 76) 2-pyrrolidinone was combined with dimethylsulphate in benzene and refluxed for 3h. After purification including distillation, the resulting 2-methylimino ester pyrrolidine was combined with excess lithium phenoxide (PhLi) in dry ether at room temperature for 18h to yield the title compound., 5264-35-7

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; The Penn State Research Foundation; EP1420021; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem