Category: 5264-35-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.,5264-35-7

To a solution of ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[3-carbamoyl-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate (500 mg) obtained in example 71(a) in ethanol (15 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole (340 mg), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (0.77 ml) at room temperature, and the resulting mixture was stirred at room temperature overnight and then evaporated in vacuo.. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 15 percent acetonitrile/water).. Subsequently, to a solution of the amorphous solid obtained in ethanol (5 ml) was added a 4N solution of hydrogen chloride in dioxane (0.50 ml), and the resulting mixture was evaporated to dryness in vacuo to afford the title compound (420 mg, yield: 67 percent) as a colorless amorphous solid. 1H NMR (500MHz, DMSO-d6) delta ppm: 1.23 (3H, t, J=7.0), 1.80-1.95 (2H, m), 2.00-2.15 (4H, m), 2.96 (2H, m), 3.45-3.55 (1H, m), 3.55-3.65 (1H, m), 3.61 (2H, m), 3.65-3.75 (1H, m), 3.75-3.85 (1H, m), 4.20 (2H, q, J=7.0), 4.37 (2H, s), 4.47 (2H, d, J=6.0), 4.86 (1H, m), 6.44 (1 H, dt, J=16.0, 6.0), 6.58 (1H, d, J=16.0), 7.28 (1H, d, J=9.0), 7.51 (1H, dd, J=9.0, 2.5), 7.55 (1H, t, J=8.0), 7.68 (1H, d, J=8.0), 7.72 (1H, d, J=8.0), 7.77 (1H, d, J=2.5), 7.87 (1H, s); IR (KBr, cm-1): 1737, 1670.

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (520mg) in MeOH (8 mL) was added (1 S)- 1 H-inden-1 -amine, 2,3-dihydro (538 mg, 4.04 mmol, CAS 61341 -86-4) at room temperature. The mixture was stirred at room temperature for 40 h. The reaction was then cooled to room temperature and concentrated. Flash column chromatography (5percent 7N NH3 in MeOH/DCM) yielded (S)-N-(2,3-dihydro-1 H-inden-1 -yl)-3,4-dihydro-2H- pyrrol-5-amine, as a white solid. 1H NMR (300MHz, CDCI3) delta: 7.30 – 7.39 (m, 5H), 7.13 – 7.28 (m, 3H), 5.25 – 5.38 (m, 1 H), 3.72 (t, J = 6.7 Hz, 2H), 2.91 – 3.04 (m, 1 H), 2.77 – 2.91 (m, 1 H), 2.54 – 2.72 (m, 1 H), 2.35 – 2.54 (m, 2H), 1.93 – 2.10 (m, 2H), 1.76 – 1.91 (m, 1H).

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALLERGAN, INC.; CHOW, Ken; GIL, Daniel W.; DONELLO, John E.; WANG, Liming; CORPUZ, Evelyn G.; FANG, Wenkui K.; SINHA, Santosh C.; DIBAS, Mohammed I.; WO2011/44229; (2011); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5264-35-7, Triethylamine is added to a mixture of 5 -methoxy-3,4-dihydro-2H- pyrrole (SM-2: 73 g, 0.73 mmol) and 3-oxopentanedioic acid diethyl ester (200 g, 0.99 mmol) at room temperature. The resulting solution is stirred for 5 days after which the reaction mixture is filtered to give 39 g (24percent yield) of 7-hydroxy-5-oxo-l,2,3,5-tetrahydro-indolizine-8- carboxylic acid ethyl ester as a white solid. The NMR spectrum of the title compound is consistent with the structure.1H NMR (CDCI3, 300 MHZ): delta 11.4 (s, 1H), 5.80 (s, 1H), 4.40 (q, 2H), 4. 15 (t, 2H), 3.50 (t, 2H), 2.3-2.15 (m, 2H), 1.40 (t, 3H).

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; WAYKOLE, Liladhar Murlidhar; KARPINSKI, Piotr H.; WO2011/67348; (2011); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

A 2L 3-necked flask equipped with a mechanical stirrer was charged with ethyl 2-amino-1 /-/-pyrrole-3-carboxylate (100 g, 0.648 mol) and 5-methoxy-3,4-dihydro-2/-/-pyrrole (128.6 g, 1.5 mol) and the mixture was stirred at 90¡ãC. After 8 h, 5-methoxy-3,4-dihydro-2H-pyrrole (45 g, 0.454 mol) was added then the mixture was kept at the same temperature overnight. It was purged with argon for 4 h then cooled to room temperature (rt). EtOAc (1 L) was added, the mixture was sonicated for 1 h and left to stand at rt overnight. The suspension was stirred for 4 h, then filtered. The solid was washed with EtOAc and dried to afford 1 ,6,7,8-tetrahydro-4H-dipyrrolo[1 ,2-a:2′,3′-d]pyrimidin-4-one as a greenish solid (96.8 g, 85.3 percent yield); LCMS [M+H]+ 176., 5264-35-7

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; (191 pag.)WO2019/119145; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

Ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate (8b) Compound 8a (Aust. J. Chem., 1999, 52, 1013-1020, 7 g, 32.3 mmol) was added to a mixture of triethylamine (0.16 mL, 1.15 mmol) and 2-methoxy-1-pyrroline (2.9 g, 29.4 mmol) and the reaction was stirred at room temperature for 10 days. The solution was concentrated in vacuo and the resulting solid was filtered and washed with diethyl ether to give 1.83 g (22percent) of the title compound as a white solid powder. 1H NMR (400 MHz,DMSO-d6): delta 11.47 (s, 1H), 4.33 (q, 2H, J=7.1 Hz), 4.00 (t, 1H, J=7.6 Hz), 3.44 (t, 2H, J=8.0 Hz), 2.03-2.16 (m, 2H), 1.83 (s, 3H), 1.33 (t, 3H, J=7.1 Hz). MS (ES) [m+H] calc’d for C12H15NO4, 238; found 238.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/124595; (2009); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5264-35-7, To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (crude) in DCM (200 mL) was added MeOH (800 mL) and aminoacetaldehyde dimethyl acetal (105 g, 1000 mmol). The mixture was stirred at 60¡ã C. for 6 h before being concentrated under reduced pressure to afford N-(2,2-dimethoxyethyl)-3,4-dihydro-2H-pyrrol-5-amine (82 g, 48percent). The crude product was dissolved in formic acid (400 mL) and stirred at reflux for 17 h before being concentrated under reduced pressure to afford 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole (46 g, 90percent). 1H NMR (400 MHz, DMSO-d6, 30¡ã C.) 2.51-2.44 (2H, m), 2.69-2.65 (2H, m), 3.91-3.88 (2H, m), 6.84 (1H, s), 7.02 (1H, s).

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca AB; Barlaam, Bernard; De Savi, Christopher; Hawkins, Janet; Hird, Alexander; Lamb, Michelle; Pike, Kurt; Vasbinder, Melissa; (134 pag.)US2016/376287; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

[0143] a) A mixture of 6.2 g 2-amino-3-cyano-thiophen and 5,95 g 5-methoxy-3,4-dihydro-2H-pyrrol are heated for 2 hrs. at 120¡ã C. and 1 hr. at 155¡ã C. with stirring. Upon cooling down to ambient temperature the mixture is diluted with acetone and solid particles are filtered off. The mixture is concentrated and methanol is added. The mixture is acidified with alcoholic HCl. Subsequently the product is precipitated by addition of diethylether and the crystals and dried to yield 4.5 g of 6,7-dihydro-5H-1-thia-4a,8-diaza-s-indacen-4-ylideneamine hydrochloride as light yellow crystals.

5264-35-7, The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Boehringer Ingelheim International GmbH; US2005/27122; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5264-35-7, To a solution of ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[4-(piperidin-4-yloxy)phenyl]sulfamoylacetate dihydrochloride (0.52 g) obtained in example 59(a) in ethanol (5 ml) were added successively 5-methoxy-3,4-dihydro-2H-pyrrole (0.26 g), which was prepared from 2-pyrrolidinone according to the method described in Org. Prep. Proced. Int., 24, 147 (1992), and triethylamine (0.60 ml) at room temperature, and the resulting mixture was stirred at room temperature for 29 hours and then evaporated in vacuo.. The residue obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: 25 percent acetonitrile/water).. Subsequently, to a solution of the amorphous solid obtained in ethanol (40 ml) was added a 4N solution of hydrogen chloride in dioxane (0.75 ml), and the resulting mixture was evaporated to dryness in vacuo.. The residue obtained was dissolved in water and then lyophilized to afford the title compound (0.43 g, yield: 77 percent) as a colorless amorphous solid. 1H NMR (400MHz, DMSO-d6) delta ppm: 1.23 (3H, t, J=7.0), 1.68-1.80 (2H, m), 2.00-2.14 (4H, m), 2.96 (2H, t, J=8.0), 3.46-3.87 (6H, m), 4.20 (2H, q, J=7.0), 4.34 (2H, s), 4.45 (2H, d, J=6.0), 4.67-4.73 (1H, m), 6.44 (1H, dt, J=16.0, 6.0), 6.55 (1H, d, J=16.0), 7.04 (2H, d, J=9.0), 7.39 (2H, d, J=9.0), 7.55 (1H, t, J=8.0), 7.68-7.73 (2H, m), 7.88 (1H, s); IR (KBr, cm-1): 1738, 1671, 1349, 1157.

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; Sankyo Company, Limited; EP1375482; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5264-35-7, To 1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethanamine (258 mg, 0.97 mmol) in methanol (5 mL) was added 5-methoxy-3,4-dihydro-2H-pyrrole (96 mg, 0.97 mmol) followed by acetic acid (2 drops). The mixture was heated at 70¡ã C. for 16 hours. The mixture was cooled to room temperature and methanol was removed. Purification by chromatography on silica gel (5percent 7N NH3 in MeOH/CH2Cl2) gave N-(1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethyl)-3,4-dihydro-2H-pyrrol-5-amine (161 mg, 50percent) as an off white solid.1H NMR (300 MHz, CD3OD) delta 1.79-1.90 (m, 2H), 2.41-2.49 (m, 2H), 2.87-2.94 (m, 1H), 3.14-3.21 (m, 1H), 3.34-3.41 (m, 2H), 5.28-5.33 (m, 1H), 7.30-7.47 (m, 4H), 7.77-7.81 (m, 1H), 8.36-8.42 (m, 1H), 8.43 (s, 1H).

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; ALLERGAN, INC.; US2010/145061; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The title compounds were synthesized according to the literature [25]. A mixture of diketone 1a or 1b (234 mmol), corresponding lactim-methylethers (258 mmol) and a catalytic amount of nickel(II) acetylacetonate (0.59 g, 2.3 mmol)was heated at 100 ¡ãC for 24 h. Then the reaction mixture was cooled. The solid products were filtered and crystallized. (In the case of 3e and 4b, water (170 mL) was added and the reaction mixture was extracted with dichloromethane (3 x 90 mL). The combined organic layers were dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the crude product. The crude product was purified chromatographically on silica gel.) The compounds prepared according to the procedure are summarised in Supplementary material., 5264-35-7

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Article; Josefi?k, Frantis?ek; Svobodova?, Marke?ta; Bertolasi, Valerio; S?imu?nek, Petr; MacHa?c?ek, Vladimi?r; Almonasy, Numan; C?ernos?kova?, Eva; Journal of Organometallic Chemistry; vol. 699; (2012); p. 75 – 81;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem