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NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer’s disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

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Pyrroline – Wikipedia,
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Toward Transition Metal-Catalyzed Carbonylation of Methanol without HI as Copromoter: Catalytic Exocyclic Carbonylation of Cycloimino Esters

(Formula presented). Initial studies of a rare exocyclic C-O bond carbonylation are reported. Under the catalysis of Co2(CO) 8 in the absence of HI as the copromoter, cycloimino esters are carbonylated to afford N-acyllactams in high yields under relatively mild conditions (100-160C and 200-1000 psi). The reaction is interesting because it opens up the possibility of carbonylation of alcohols in the absence of HI.

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NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1? RECEPTOR LIGANDS

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

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SYNTHESIS OF NOVEL BICYCLIC 2-AMINO-4(1H)-PYRIDONES. REACTION OF LACTIM ETHERS WITH alpha-CYANOACETONE DIANION.

Reaction of lactim ethers with alpha-cyanoacetone dianion gave bicyclic 2-amino-4(1H)-pyridones.

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Pyrroline – Wikipedia,
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NEW PYRIDINE ANALOGUES VIII 518

The present invention relates to certain new pyridin analogues of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

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Ring-Chain Transformations, IX. Synthesis and Ring-Chain Tautomerism of 2-(omega-Aminoalkyl)-1,3,4-thiadiazoles

Thiohydrazide compounds 1 react with lactam acetals 2 or lactim ethers 3 by condensation giving unusual zwitterionic tautomers 5 of lactam thioacylhydrazones 4.These compounds 5 form mixtures of tautomers in neutral solution.In acidic solution, however, most of them undergo a reversible ring-chain transformation to novel 2-(omega-aminoalkyl)-1,3,4-thiadiazole salts 9.Alkylation of zwitterionic thioacylamidrazones 5 gives S-alkylation products 6.

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Pyrroline – Wikipedia,
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Chelate-assisted synthesis of pyrazolylidene derivatives from cyanoacetic acid hydrazide and O-methyl lactims

Diphenylboron chelate of cyanoacetic acid hydrazide and O-methyl lactims were used to synthesize pyrrolidin-, piperidin-, and azepan-2-ylidene derivatives of 3-aminopyrazol-5-one.

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PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.

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Study of reactions of lactim ethers with cyanoacetohydrazide

Main pathways in reactions of lactim ethers with cyanoacetic acid hydrazide depend on the ring size of the starting lactim ether. Five-membered O-methylbutyrolactim produces pre-dominantly 3-amino-4-(pyrrolidin-2-ylidene)-4, 5-dihydropyrazol-5-one, whereas condensation of six-and seven-membered lactim ethers (O-methylvalero-and O-methylcaprolactim, respectively) affords the corresponding polymethylenetriazoles as the major products.

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A new bicyclic oxazaborines with a bridged nitrogen atom, their thermic rearrangement and fluorescence properties

Cyclic beta-enaminones bearing secondary amino group react with 4-substituted benzenediazonium tetraphenylborates in dichloromethane to form substituted bicyclic [1,3,2lambda4]oxazaborines The oxazaborines rearrange, on heating to 200 C in the absence of solvent or in DMF or DMSO, to isomeric 2H-[1,2,4,3lambda4]triazaborines. Previously prepared [1,3,2lambda4]oxazaborines derived from acyclic beta-enaminones bearing secondary amino group either did not undergo the rearrangement or with a lot of difficulties and with negligible yield. The fluorescence behaviour of the prepared triazaborines was observed. These compounds fluoresce in 2-methyltetrahydrofurane and in solid state under low temperatures.

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Pyrroline – Wikipedia,
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