Category: pyrrolines

55750-48-6, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. Here is a downstream synthesis route of the compound 55750-48-6

55750-48-6, Step 1: t-Butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate(250 mg, 1.0 mmol) andmethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (156 mg, 1.0 mmol) were combined in saturated aqueous NaHCO3 (10 ml) and stirred for 1.5 h at 0C. The reaction mixture was acidified to pH 2 with hydrochloric acid (2 M) and extracted with EtOAc. The organic phase was washed with brine, dried with MgSO4, and concentrated. The crude was purified by ISCO using 0-4% MeOH/DCM to give t-butyl (2- (2-(2-(2,5 -dioxo-2,5 -dihydro- 1 H-pyrrol- 1 -yl)ethoxy)ethoxy)ethyl)carbamate as a colorless oil. MS m/z 229.2(M+1-Boc). Retention time 0.963 mm. ?H NMR (400 MHz, Chloroform-d) 6 6.71 (s, 2H), 5.04 (bs,1H), 3.74 (t, J = 5.4 Hz, 2H), 3.64 (t, J = 5.4 Hz, 2H), 3.61-3.59 (m, 2H), 3.56-3.54 (m, 2H), 3.50 (t, J =5.2 Hz, 2H), 3.31-3.26(m, 2H), 1.44 (s, 9H).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 55750-48-6

Reference£º
Patent; NOVARTIS AG; ABRAMS, Tinya; COHEN, Steven; D’ALESSIO, Joseph Anthony; DAMIANO, Jason; DURR, Clemens; GEIERSTANGER, Bernhard Hubert; HU, Qi-Ying; HUBER, Thomas; IMASE, Hidetomo; JIN, Yunho; MENEZES, Daniel; MILLER, Kathy; MOHSENI, Morvarid; OU, Weijia; RENDAHL, Katherine; UNO, Tetsuo; WAN, Yongqin; WANG, Xing; (350 pag.)WO2016/203432; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route., 5264-35-7

Triethylamine is added to a mixture of 5-methoxy-3,4-dihydro-2H-pyrrole (73 g, 0.73 mmol) and 3-oxopentanedioic acid diethyl ester (200 g, 0.99 mmol) at room temperature. The resulting solution is stirred for 5 days after which the reaction mixture is filtered to give 39 g (24percent yield) of 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester as a white solid. The NMR spectrum of the title compound is according to theory.1H NMR (CDCl3, 300 MHZ): delta 11.4 (s, 1H), 5.80 (s, 1H), 4.40 (q, 2H), 4.15 (t, 2H), 3.50 (t, 2H), 2.3-2.15 (m, 2H), 1.40 (t, 3H).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5-Methoxy-3,4-dihydro-2H-pyrrole

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Patent; Novartis AG; US2009/275606; (2009); A1;,
Pyrroline – Wikipedia
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.31970-04-4, name is Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate. Here is a downstream synthesis route of the compound 31970-04-4. 31970-04-4

Benzyl 6-oxa-3-azabicvclo[3.1.Olhexane-3-carboxylate z To a solution of benzyl 2,5-dihydro-1 H-pyrrole-1-carboxylate (33 g, 163 mmol; 90% from Aldrich) in dichloromethane (540 ml_, 0.3 M solution) was added m-CPBA (44 g, 340 mmol, 77% from Aldrich). After the reaction mixture was stirred at room temperature for 18 h, 500 ml_ of saturated Na2C03 aqueous solution was added and the resulting mixture was stirred at room temperature for 1 h. The organic layer was separated, washed with water and brine, dried over anhydrous Na2S04, filtered, and concentrated in vacuo. The desired product as a yellow oil was obtained in 83% yield (29.5 g) by flash column chromatography. Rf = 0.5 (30% EtOAc in hexanes). 1H NMR (CDCI3, 400 MHz): delta 3.38 (2H, dd, J = 12.8, 6.0 Hz ), 3.68 (2H, d, J = 3.6 Hz), 3.87 (2H, dd, J = 13.2, 19.6), 5.1 1 (2H, s), 7.33( 5H, m). LC/MS (uplc): MH+ 220.0, 0.69 min., 31970-04-4

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 31970-04-4

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Patent; NOVARTIS AG; IRM LLC; BARSANTI, Paul A.; CHAMOIN, Sylvie; DOUMAMPOUOM-METOUL, Lionel; GEIERSTANGER, Bernhard Hubert; GROTZFELD, Robert Martin; GUERRO-LAGASSE, Stephanie; JONES, Darryl Brynley; KARPOV, Alexei; LAFRANCE, Marc; NIETO-OBERHUBER, Cristina; OU, Weijia; PIIZZI, Grazia; WO2014/151030; (2014); A1;,
Pyrroline – Wikipedia
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. An updated downstream synthesis route of 1334177-86-4 as follows., 1334177-86-4

(C) (115,1 laS) -4-((2R, 5R) -3 7-(2, 5-dioxo-2 , 5-dihydro- 1H-pyrrol- 1-yI)-5-isopropyl-2-methyl- 4,7, 35-trioxo- 10, 13, 16, 19,22,25,28,3 1-octaoxa-3, 6, 34-triazaheptatriacontanamido)benzyl 11- hydroxy-8-((5-(((1 15, 1 laS)- 1 1-hydroxy- 1 0-(((4-((1OR, 13R)- lO-isopropyl- 13-met hyl-8, 11- dioxo-2, 5-dioxa-9, 12-diazatetradecanamido) benzyl) oxy)carbonyl)- 7-methoxy-2-methyl-5- oxo-5, 10, 11, 1 la-tetrahydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiazepin-8-yI) oxy)pentyl) oxy) -7- methoxy-2-methyl-5-oxo- 11,1 la-dihydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiaze pine- 10(5H)- carboxylate (106)N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 105 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) in chloroform (5 mL). The reaction was stirred for 1.5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/i0% methanol] gave 106 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 mm; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5).

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid, you can also browse my other articles.

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Patent; CANCER RESEARCH TECHNOLOGY LIMITED; VAN BERKEL, Patricius Henrikus Cornelis; HOWARD, Philip Wilson; WILLIAMS, David G; WO2015/159076; (2015); A1;,
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1-Pyrroline | C4H7N – PubChem

872-32-2, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.872-32-2, name is 2-Methyl-1-pyrroline. A new synthetic method of this compound is introduced below.

872-32-2, 5-Methyl-3,4-dihydro-2H-pyrrole (1.00 g, 12.0 mmol) was dissolved in carbon tetrachloride. To the solution was added NCS (12.85 g, 96 mmol) as a solid and reaction mixture heated to 85 0C and stirred overnight. The mixture was cooled to 0 0C and the precipitate filtered off and the solvent evaporated. The residue was dissolved in methanol and sodium methoxide (3.90 g, 72.2 mmol) was added. The resulting suspension was heated to reflux and stirred for 3 h. The methanol was evaporated and the residue suspended in Et20. The solid was filtered off and the ether evaporated. The residue was dissolved in DCM and 2M HCI was added. The biphasic solution was stirred until no SM remained. The phases were separated and the organic layer was dried over MgSO4 and evaporated to an orange oil. The crude oil was adsorbed onto silica and run on 40 g of silica with EtOAc and Hexanes to afford the title compound as an orange solid (0.2958 g, 1.854 mmol, 15.41 percent yield). 1H NMR (400 MHz, CDCI3): delta ppm 9.54 (br. s., 1 H), 6.80 (s., 1 H), 6.17 (s., 1 H), 3.83 (s, 3 H). MS: m/z 160.0 (M+1 ).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 872-32-2. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.17057-04-4, name is 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid. A new synthetic method of this compound is introduced below.

General procedure: An oven-dried flask was cooled under a stream of nitrogen and charged with azomethine N-oxide 1 (5 mmol), maleimide 2 (5 mmol) and sodium dried toluene (25 mL). The flask was equipped with a reflux condenser and the mixture was refluxed for 6 hrs (Scheme 3) until the substrates were consumed as judged by TLC. On completion the reaction mixture was concentrated and the precipitated compound was filtered. The crude product consists of a mixture of cis and trans isomers which was subjected to column chromatography over silica gel (100-200 mesh) using hexane: ethyl acetate (9:1) mixture as eluent., 17057-04-4

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 17057-04-4, you can also browse my other articles.

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Article; Kaur, Anjandeep; Singh, Baldev; Jaggi, Amteshwar Singh; Bioorganic and Medicinal Chemistry Letters; vol. 23; 3; (2013); p. 797 – 801;,
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The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.25021-08-3, name is 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid. A new synthetic method of this compound is introduced below., 25021-08-3

[0001236] To a mixture of Example 2.160.3 (557.5 mg), 2-(2,5-dioxo-2,5-dihydro- lH-pyrrol-l- yl)acetic acid (272 mg) and 0-(7-azabenzotriazol-l-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (667 mg) inN N-dimethylformamide (1.75 mL) at 0 C was added Nu,Nu- diisopropylethylamine (0.459 mL). The resulting mixture was stirred at 0 C for 1 hour. The reaction mixture was mixed with saturated aqueous NH4C1 mixture, extracted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography, eluting with petroleum ether/ ethyl acetate (2/1), to provide the title compound. MS (LC-MS) m/e 795.3 (M+Na) +., 25021-08-3

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 25021-08-3, you can also browse my other articles.

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Patent; ABBVIE INC.; TAO, Zhi-Fu; DOHERTY, George; WANG, Xilu; SULLIVAN, Gerard M.; SONG, Xiaohong; KUNZER, Aaron R.; WENDT, Michael D.; MARIN, Violeta L.; FREY, Robin R.; CULLEN, Steve C.; WELCH, Dennie S.; SHEN, Xiaoqiang; BENNETT, Nathan B.; HAIGHT, Anthony R.; ACKLER, Scott L.; BOGHAERT, Erwin R.; SOUERS, Andrew J.; JUDD, Andrew S.; (623 pag.)WO2016/94509; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route.

A mixture of chelate 8 (0.32 g, 1 mmol) and butyrolactim 2a (n = 1) (0.39 g, 4 mmol) was refluxed in toluene (7 mL) for 20 h. The solvent was evaporated, the residue was three times crystallized from ethanol to obtain chelate 10a (0.16 g, 42percent) with m.p. 235?236 C (decomp.)., 5264-35-7

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 5264-35-7, you can also browse my other articles.

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Article; Ruban; Potapova; Baranin; Dorokhov; Russian Chemical Bulletin; vol. 63; 10; (2014); p. 2260 – 2263; Izv. Akad. Nauk, Ser. Khim.; vol. 63; 10; (2014); p. 2260 – 2263,4;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. A new synthetic method of this compound is introduced below.

N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 42 (203 mg, 0.146 mmol) and maleimide-PEGs acid (87 mg, 0.146 mmol) in chloroform (5 ml_). The reaction was stirred for 1 .5 h then diluted with chloroform (50 ml_), washed with water (50 ml_), brine (30 ml_), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/10% methanol] gave 43 as a pale yellow solid (205 mg, 72%). LC/MS, System 1 : RT 5.75 min; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5)., 1334177-86-4

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid, you can also browse my other articles.

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Patent; SPIROGEN SARL; HOWARD, Philip, Wilson; EZEADI, Ebele; D’HOOGE, Francois; PATEL, Neki; KEMP, Gary; WO2015/52322; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

69778-83-2, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.69778-83-2, name is 4-Methoxy-1H-pyrrol-2(5H)-one. An updated downstream synthesis route of 69778-83-2 as follows.

Example 1 Compound (VII) To a solution of 2-formyl-5-undecylpyrrole (4 g; 16.03 mmols) and 4-methoxy-3-pyrrolin-2-one (3.63 g; 32.06 mmols) in DMSO (53 ml) 2N sodium hydroxyde (45 ml) is added under nitrogen atmosphere and the mixture is stirred at 60¡ã C. for 8 hours. After dilution with water (200 ml) the yellow suspension is extracted with dichloromethane (600 ml). The organic phase is shacked with water and brine, anhydrified over anhydrous sodium sulphate and evaporated to dryness. The crude material is taken up in hexane and filtered to give 4-methoxy-5-(5-undecyl-1H-pyrrol-2-yl-methylene)-1,5-dihydro-pyrrol-2-one (4.86 g; 14.11 mmols) as a yellow crystalline solid. Yield: 88percent. 1 NMR (400 mhz, CDCl3), ppm: 0.87 (3H, m), 1.2-1.5 (16H, m), 1.72 (2H, m), 2.73 (2H, m), 3.89 (3H, s), 5.08 (1H, d, J=1.7 Hz), 5.97 (1H, dd, J=2.4 and 3.2 Hz), 6.31 (1H, s), 6.36 (1H, t, J=3.2 Hz), 10.25 (1H, bs), 10.74 (1H, bs)., 69778-83-2

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 69778-83-2

Reference£º
Patent; Pharmacia & UpJohn S.p.A.; US5847127; (1998); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem