Category: pyrrolines

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate (2.00 g, 9.80 mmol) in CH2Cl2 (10 mL) was added slowly 3-chloroperbenzoic acid (3.00 g, 14.80 mmol) at 0¡ã C. The reaction mixture was stirred for 13 h at room temperature, then quenched with saturated sodium thiosulfate aqueous solution and extracted with EtOAc. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 6:1 (v/v) PE/EtOAc) to give the title compound as colorless oil (1.75 g, 81.02percent)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; Zhang, Jiancun; Zhang, Yingjun; Zhang, Weihong; Liu, Bing; Zhang, Jiquan; Liu, Jinlei; Zhang, Lu; US2014/228361; (2014); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, General procedure: The maleimide was added to a suspension of P25 in methanol (10%) and acetonitrile (90%). The resulting mixture was then purged with argon for 15 min. The mixture was irradiated with eight 29 cm 15 W Philips Cleo tubes (lambda = 350 nm). Following irradiation the P25 powder was removed via filtration through Celite.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manley, David W.; Buzzetti, Luca; MacKessack-Leitch, Andrew; Walton, John C.; Molecules; vol. 19; 9; (2014); p. 15324 – 15338;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 2; Ci5-l-methyl-3 (9Z,12ZVocta^^; Benzyl 3,4-dihvdroxypyrrolidine-l-carboxylate (9): In a 500 mL RBF, the Cbz Pyrroline (15 gs 73.8 mmol) was dissolved in a mixture of 100 mL THF, 60 mL t-BuOH and 40 mL water for addition of the NMO (30.6 ml, 148 mmol) solution followed by the osmium tetraoxide (0.925 ml, 0.074 mmol) solution. Heated in a 70C oil bath. Solution slowly went from yellow to brown. After 2h, cooled to RT and added 50 mL 10percent aqueous NaHS03. Concentrated and partitioned between 100 mL brine and 100 mL EtOAc. Separated layers and extracted with 100 mL EtOAc. Dried over MgS04, filtered and concentrated to 22.3 g of thick yellow oil. Flash column chromatography from 50-100percent EtOAc in hexane provided compound 9. .H NMR (400 MHz, CDC13) 5 7.35 (m, 5H), 5.22 (s, 2H), 4.42 (m, 4H), 3.63 (m, 2H), 3.42 (m, 3H), 3.20 (m, IH)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; STANTON, Matthew, G.; BEUTNER, Gregory, L.; WO2012/61259; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.,55750-48-6

[ 4313] 30 mg (30 f.tmol) oflntermediate 89 were taken up in2 ml of 1 ,4-dioxane and admixed with 4 ml of saturatedsodium hydrogencarbonate solution and then with 7.5 mg (50f.tmol) of methyl 2,5-dioxo-2,5-dihydro-18-pyrrole-1-carboxylate.The reaction mixture was stirred at RT for 1 handthen concentrated in vacuo. The remaining residue was purifiedby means of preparative HPLC. After lyophilization, 24mg (74% of theory) of the title compound were obtained.[4314] HPLC (Method 5): R,=2.2 min;[4315] LC-MS (Method 1): R,=l.Ol min; MS (ESipos):rnlz=1006 (M+Hr.

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

The reaction mixture comprising 1 mmol of 1-[N-(5,5-dimethyl-3,4,5,6-tetrahydropyrimidinium-2-yl)amino]dodecane-12-ammonium ditrifluoroacetate, 1 mmol (1 eq.) of 3,4-dihydro-5-methoxy-2H-pyrrole and 0.5 ml of triethylamine in 10 ml of absolute ethanol is heated under reflux for 20 hours. After cooling down to ambient temperature, the reaction mixture is evaporated to dryness and chromatographed on a silica column (CH2Cl2/CH3OH/NH4OH 85:13:2) in order to produce the product, in the form of an oil, with a yield of 65percent. NMR 1H (CD3OD, 360 MHz), delta (ppm): 1.12 (s, 6H); 1.36 (m, 16H); 1.60 (n, 2H); 1.69 (m, 2H); 2.28 (m, 2H); 2.93 (m, 2H); 3.09 (s, 4H); 3.22 (m, 2H); 3.31 (m, 2H); 3.75 (m, 2H). MS-ES+: [M+H]+: 378; [M+H+TFA]+: 492; [M+2H]++/2: 189.5

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2005/176819; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: Benzyl cis-3,4-dihvdroxypyrrolidine-l-carboxylate (127)To a solution of compound 126 (3.0 g, 14.76 mmol) in a mixture of acetone and water (32 mL and 6 mL) was added N-methylmorpholine-N- oxide (2.25 g, 19.21 mmol) followed by the addition of osmium tetroxide solution (4percent aqueous, 0.7 mL). The yellow mixture was stirred at ambient temperature overnight. To this solution was added solid sodium metabisulfite (Na2S205, 5.0 g) and the mixture was stirred for 1 h. Acetone was removed from the reaction mixture by evaporation, and the solid obtained was suspended in ethyl acetate and filtered. The solid was dissolved in water, extracted with ethyl acetate and combined with the filtrate. The organic phase was washed with brine, dried (Na2S04) and evaporated to get the crude compound 127. This material was purified by flash chromatography using 1-8percent methanol /dichloromethane as eluent to isolate the pure product as a white solid (3.02 g, 86percent).1H NMR (CDC13, 300MHz) : delta ppm 7.39-7.26 (m, 5H), 5.11 (s, 2H), 4.28-4.20 (m, 2H), 3.65 (dd, J = 11.0, 5.5 Hz, 2H), 3.41 (dt, J = 11.0, 4.1 Hz, 2H), 2.61-2.58 (m, 2H). APCI+ = 238., 31970-04-4

As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; ALNYLAM PHARMACEUTICALS, INC.; RAJEEV, Kallanthottathil, G.; MANOHARAN, Muthiah; JAYARAMAN, Muthusamy; MAIER, Martin; JAYAPRAKASH, Narayanannair, K.; BUTLER, David; WO2012/99755; (2012); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

3. 2-diphenylpyrrole (Compound 76) 2-pyrrolidinone was combined with dimethylsulphate in benzene and refluxed for 3h. After purification including distillation, the resulting 2-methylimino ester pyrrolidine was combined with excess lithium phenoxide (PhLi) in dry ether at room temperature for 18h to yield the title compound., 5264-35-7

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; The Penn State Research Foundation; EP1420021; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-49-7, Ethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55750-49-7, To a solution of 1-((tert-butoxycarbonyl)amino)-2-aminoethane (42)23 26, 27 (1.13 g, 7.1 minol) in saturated NaHCO3 (35 mL) at 0 C was added N-(ethoxycarbonyl)maleimide22 (45) (1.1 g, 7.1 minol). The reaction mixture was warmed to rt and stirred for 15 min.THF (55 mL) was then added and the reaction mixture stirred for a further 45 mi H20 (50 mL) was added and the aqueous phase extracted with EtOAc (3 x 75 mL). The combined organic extracts were washed with saturated NaCI (100 mL) and dried over Mg504. Removal of the solvent in vacuo gave an off-white solid that was purified by flash chromatography (0%, then 5%, then 10% EtOAc in CH2CI2) to yleld the title compound 46(1.1 g 58%) as a white solid. Mp. 126-128 C; Rf(10% EtOAc in CH2CI2) 0.28; IR (ATR)vmaxjcm1 3350 (C-H), 3089 (C-H), 2977, 1701 (C=O), 1678 (C=O), 1516, 1434, 1288,1256, 1167, 944, 844, 692, 623; 1H NMR (400 MHz, CDCI3) oe 1.40 (9H, 5), 3.30-3.35 (2H,m), 3.66 (2H, t, J = 6.0 Hz), 4.74 (1H, br 5), 6.71 (2H, 5); 13C NMR (100 MHz, CDCI3) oe28.3, 38.0, 39.4, 79.5, 131.1, 155.9, 170.8. The 1H and 13C NMR data obtained was in agreement with that reported from literature.23

As the paragraph descriping shows that 55750-49-7 is playing an increasingly important role.

Reference£º
Patent; SAMMUT, Ivan Andrew; HARRISON, Joanne Clare; HEWITT, Russell James; READ, Morgayn Iona; STANLEY, Nathan John; WOODS, Laura Molly; KUEH, Jui Thiang Brian; JAY-SMITH, Morgan; SMITH, Robin Andrew James; GILES, Gregory; LARSEN, Lesley; RENNISON, David; BRIMBLE, Margaret Anne; LARSEN, David Samuel; (209 pag.)WO2017/95237; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step I: Epoxidation of alkene[00146] To a solution of benzyl 2,5-dihydro- 1 H-pyrrole- 1 -carboxylate (33 g, 163 mmol) in dichloromethane (0.3 M solution) was added MCPBA (44 g, 340 mmol, 77% from Aldrich). After the reaction mixture was stirred at room temperature for 18 h, 500 mL of saturated Na2C03 aqueous solution was added and the resulting mixture was stirred at room temperature for 1 h. The organic layer was separated, washed with water and brine, dried over anhydrous Na2S04, filtered, and concentrated in vacuo. The desired product as a yellow oil was obtained in 83% yield (29.5 g) by flash column chromatography. NMR (CDCl3j 400 MHz): delta 3.38 (2H, m ), 3.68 (2H, m), 3.87 (2H, m), 5.1 1 (2H, s), 7.33( 5H, m). LC/MS (uplc): MH+ 220.0, 0.69 min.

31970-04-4, As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; BARSANTI, Paul, A.; DING, Yu; HAN, Wooseok; WO2011/128388; (2011); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55750-48-6, To a cooled (0 C) solution of 5-aminopentan-1-ol (100 mg, 0.97 tmol) in saturated aqueous NaHCO3 (16 mL) was added N-methoxycarbonylmaleimide (150 mg, 0.64 tmol). The mixture was stirred for 1.5 h and extracted with DCM (2 x 20 mL). Thecombined organic layers were dried (Na2SO4) and concentrated. The product 47 was obtained as a colorless oil (137 mg, 0.75 mmol, 75%). ?H NIVIR (400 MHz, CDC13) (ppm) 6.69 (s, 2H), 3.70-3.67 (m, 1H), 3.67-3.60 (m, 2H), 3.53 (t, J 7.1 Hz, 2H), 1.68- 1.54 (m, 4H), 1.42-1.31 (m, 2H).

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN BERKEL, Sander Sebastiaan; VAN DELFT, Floris Louis; (150 pag.)WO2016/53107; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem