Category: pyrrolines

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: A mixture of 2-methyl-1-pyrroline (2.8 g, 33.7 mmol) and the corresponding cyclic phosphite 2a-2e (30.6 mmol) were stirred in toluene (5 mL) for 4-6 h at room temperature (conversion was checked by TLC or 31P NMR), the mixture was poured into 30 mL water, slowly acidified to pH 3 with 11 N HCl then quickly extracted with tert-butyl methyl ether (TBME) (3 .x. 20 mL). The aqueous phase was basified to pH 9-10 with NaOH pellets then extracted with CH2Cl2 (4 .x. 20 mL). The combined organic phases were dried over MgSO4, filtered and roto-evaporated to give the crude aminophosphonates 3a-3e as white powders which were then purified by SiO2 column chromatography with eluent CH2Cl2/EtOH 8/1.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Gosset, Gae?lle; Cle?ment, Jean-Louis; Culcasi, Marcel; Rockenbauer, Antal; Pietri, Sylvia; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2218 – 2230;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, 186 mg (555 mumol) of 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid trifluoroacetate were dissolved in 2.6 ml of saturated sodium hydrogencarbonate solution and admixed at 0 C. with 86 mg (555 mumol) of N-methoxycarbonylmaleimide. The reaction mixture was stirred at 0 C. for 40 min and at RT for 1 h, then cooled again to 0 C., adjusted to pH 3 with sulphuric acid and extracted 3¡Á with 25 ml of ethyl acetate. The combined organic phases were dried over magnesium sulphate and concentrated. [1548] 126 mg (75% of theory) of the title compound were obtained. [1549] LC-MS (Method 1): Rt=0.53 min; m/z=302 (M+H)+

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; Lerchen, Hans-Georg; Hammer, Stefanie; Harrenga, Axel; Kopitz, Charlotte Christine; Nising, Carl Friedrich; Sommer, Anette; Stelte-Luowig, Beatrix; Mahlert, Christoph; Schuhmacher, Joachim; Golfier, Sven; Greven, Simone; Bruder, Sandra; US2015/23989; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Benzyl 2H-pyrrole-l(5H)-carboxylate (25 g, 0.12 mol) was dissolved in DCM (500 mL) at 00C. m-CPBA (42 g, 0.24 mol) was added in portions at 00C, and the mixture was stirred at RT for 3 days. The reaction mixture was filtered, and the filtrate was washed Na2S2O3 (3 M, 100 mL), NaHCO3 (1 M, 100 mL) and brine (100 mL). The organic layer was dried over Na2SO4 and purified by silica gel chromatography (PE : EtOAc = 10:1) to afford the product benzyl 6-oxa-3-aza-bicyclo[3.1.0]hexane-3- carboxylate (10 g, 37%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3): delta 7.39-7.26 (m, 5H), 5.11 (d, 2H), 3.83 (dd, 2H), 3.68 (d, 2H), 3.39 (dd, 2H).

31970-04-4, As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1B (2.1 g, 10 mmol), 194 5-methoxy-3,4-dihydro-2H-pyrrole (1.49 g, 15 mmol) and 4 cetic acid (5 drops) in 170 methanol (12 mL) was heated by microwave at 100 C. for 2 hours. The mixture was concentrated and the residue was purified by column chromatography on silica gel (EtOAc/Pet. Ether, 1/4 to 4/1, v/v) to give 76A (2 g, 76% yield) as a white 195solid: ESI m/z 266.9, 264.9 [M+H]+ ., 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Seal Rock Therapeutics, Inc.; BROWN, Samuel David; US2018/291002; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, [4325] 64 mg (70 flillOI) ofN-(6-aminohexyl)-N-methyl-Lvalyl-N -[ (3R,4S,5S)-3-methoxy-1-{ (2S)-2-[ (1 R,2R)-1-methoxy-2-methyl-3-{ [ (1 S,2R)-1-(1 ,2-oxazinan-2-ylcarbonyl)-2-phenylcyclopropyl]amino }-3-oxopropyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N -methyl-L-valinamide(Intermediate 97) were taken up in 3 ml of 1:1 dioxane/water,then adjusted to pH 9 with 4 ml of saturated sodium hydrogencarbonatesolution and subsequently admixed with 16.3mg (11 0 f.tmol) of methyl2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. The reaction mixture was stirred at RT for 1 hand then concentrated in vacuo. Then another 8 mg (55 f.tmol)of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylatewere added, and the reaction mixture was adjusted again to189Sep.3,2015pH 9 and stirred at RT for another hour. This was followed byconcentration and purification of the remaining residue bymeans of preparative HPLC. At first, 31 mg of an as yetuncyclized intermediate were obtained. 27 mg of this intermediatewere taken up again in 2 ml of 1:1 dioxane/water andthen admixed with 250 fll of saturated sodium hydrogencarbonatesolution. After stirring at RT for 2 hours, the reactionmixture was concentrated, and the residue was purified bymeans of preparative HPLC. After lyophilization, 20 mg(29% of theory) of the title compound were obtained.[4326] HPLC (Method 5): R,=l.96 min;[4327] LC-MS (Method 1): R,=0.97 min; MS (ESipos):rnz=992 (M+Hr.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55750-48-6, Preparation of Intermediate 4-(4-(2, 5-dioxo-2 , 5-dihydro- 1H-p yrrol- 1-yI)butyl)- 1, 2,4-triazolidine-3,5-dione (I-14b):To 4-(4-aminobutyl)-1 ,2,4-triazolidine-3,5-dione hydrochloride (I-i 4a: 42 mg, 0.201 mmol) in NaHCO3 sat aqueous solution (1.006 mL) at 0C was added N-methoxycarbonylmaleimide (31.2 mg, 0.20 1 mmol). The mixture was stirred at 0C for 1 h, and then at room temperature for 2h. The mixture was purified by preparative hplc (0-60% CH3CN(0.1 %TFA in H20)), and then lyophilized, giving 4-(4-(2,5-dioxo-2,5-dihydro-1 H-pyrrol1-yl)butyl)-1,2,4-triazolidine-3,5-dione (l-14b: 10 mg, 20%) a white solid. LC-MS (M+1) 253.3,= 0.89 minute. 1H NMR (400 MHz, CD3CN) 6 ppm 1.51 – 1.62 (m, 4 H) 3.45 (t, J=6.44 Hz, 2 H)3.49 (t, J=6.44 Hz, 2 H) 6.76 (s, 2 H) 7.52 (br. s., 2 H).

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; ADAMO, Roberto; ALLAN, Martin; BERTI, Francesco; DANIELI, Elisa; HU, Qi-Ying; WO2013/9564; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.,5264-35-7

To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1 .98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 1 10 (M+H). 1 H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1 H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CHALTIN, Patrick; CHRIST, Frauke; DEBYSER, Zeger; DE MAEYER, Marc; MARCHAND, Arnaud; MARCHAND, Damien; VOET, Arnout; WO2012/65963; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of benzyl 2,5-dihydro-l H-pyrrole-l -carboxylate (2.00 g, 9.80 mmol) in CH2C12 (10 mL) was added slowly 3-chloroperbenzoic acid (3.00 g, 14.80 mmol) at 0 ¡ãC. The reaction mixture was stirred for 13 h at room temperature, then quenched with saturated sodium thiosulfate aqueous solution and extracted with EtOAc. The organic phase was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 6: 1 (v/v) PE/EtOAc) to give the title compound as colorless oil (1.75 g, 81.02 percent)., 31970-04-4

As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem