Category: pyrrolines

55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55750-48-6

0-(P-D-glucopyranos-1 -yl)decyl-maleimide (38) N-(methoxycarbonyl) maleimide(37) (0.014 g, 0.09 mmol) was added at RT to a stirring solution of (10-Aminodecyl) p-D-glucopyranoside(0.015 g, 0.04 mmol) in dioxane (0.75 ml_) and sat. NaHC03 (aq) (1.5 ml_). The reaction was stirred for 1 hr after which the reaction was quenched with EtOAc (10 ml_) and water (10 mL). The organic phase was separated out and the aq. phase extracted with EtOAc (3 x 10 mL). The organic layers were combined, dried, filtered and the solvent evaporated under vacuum. The residue was adsorbed onto silica and purified with column chromatography (CH2CI2: MeOH 9: 1 ). The title compound was obtained as a clear oil (0.01 1 g, 60 %) Rf = 0.15 (CH2CI2: MeOH 9:1 ) deltaEta (CD3OD, 300 MHz): 6.79 (2H, s, 374′), 4.24 (1 H, d, J = 7.5 Hz, H-1 “), 3.93-3.84 (2H, m, H-6″a/H-10a), 3.69-3.64 (1 H, m, H-6″b), 3.57-3.50 (1 H, dt, J = 6.6, 9.6 Hz, H-10b), 3.48 (2H, t, J = 6.9 Hz, H-1 ), 3.38-3.22 (3H, m, H-3’74’75”), 3.19-3.13 (1 H, m, H-2″), 1.64-1 .54 (4H, m, H-2/9), 1.42-1 .28 (12H, m, AlkCHz). 5C (CD3OD, 100 MHz): 172.6 (C-275′), 135.3 (C-374′), 104.4 (C-1 “), 78.2 (C-3″), 77.9 (C-2″), 75.1 (C-5″), 71 .7 (C-10), 70.9 (C-4″), 62.8 (C-6”), 38.5 (C-1 ), 30.8 (C-2), 30.5 (x3), 30.1 , 29.4, 27.7, 27.0 (CH2Alk)

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED; UNIVERSITY OF CAPE TOWN; DRIVER, Cathryn Helena Stanford; ZEEVAART, Jan Rijn; PARKER, Mohamed Iqbal; HUNTER, Roger; (67 pag.)WO2016/46793; (2016); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

To a flask containing 18-1 (2.87 g, 28.9 mmol) at room temperature, diethyl 1,3-acetonedicarboxylate (7.90 mL, 43.4 mmol) and triethylamine (0.45 mL, 3.2 mmol) were added. The mixture was stirred at room temperature overnight then was heated to 35¡ã C. for 3 days. The mixture was cooled to room temperature and diluted with ether. The resulting suspension was filtered, washing with ether. Additional solid precipitated from the filtrate which was collected by filtration. The combined solids were dried under vacuum to give ethyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate (18-2, 2.52 g) as a white solid.

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; Aviara Pharmaceuticals, Inc.; Biediger, Ronald J.; Benish, Michele A.; Hardy, Lindsay Bonner; Boyd, Vincent A.; Market, Robert V.; Thrash, Thomas P.; Young, Brandon M.; (83 pag.)US2018/312523; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.

872-32-2, 5-Methyl-3,4-dihydro-2H-pyrrole (1.00 g, 12.0 mmol) was dissolved in carbon tetrachloride. To the solution was added NCS (12.85 g, 96 mmol) as a solid and reaction mixture heated to 85 0C and stirred overnight. The mixture was cooled to 0 0C and the precipitate filtered off and the solvent evaporated. The residue was dissolved in methanol and sodium methoxide (3.90 g, 72.2 mmol) was added. The resulting suspension was heated to reflux and stirred for 3 h. The methanol was evaporated and the residue suspended in Et20. The solid was filtered off and the ether evaporated. The residue was dissolved in DCM and 2M HCI was added. The biphasic solution was stirred until no SM remained. The phases were separated and the organic layer was dried over MgSO4 and evaporated to an orange oil. The crude oil was adsorbed onto silica and run on 40 g of silica with EtOAc and Hexanes to afford the title compound as an orange solid (0.2958 g, 1.854 mmol, 15.41 percent yield). 1H NMR (400 MHz, CDCI3): delta ppm 9.54 (br. s., 1 H), 6.80 (s., 1 H), 6.17 (s., 1 H), 3.83 (s, 3 H). MS: m/z 160.0 (M+1 ).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[BENZYL-3-PYRROLINE-1-CARBOXYLATE] (5 g, 24.6 mmol) and 3-chloroperoxybenzoic acid (8.5 g, 49.2 mmol) were dissolved in dichloromethane (250 [ML)] and stirred for 16 h at room temperature. The reaction mixture was washed with sat. [NAHC03,] brine and dried [(MGS04).] The title compound was isolated by silica gel chromatography (0-35% EtOAc-hexanes). Yield 3.6 g (68%). [1H NMR] (300 MHz, [CDC13)] : 3.34-3. 40 (d, [J=] 11 Hz, 2H), 3.66 (s, 2H), 3.80- 3.89 (t, [J=] 12 Hz, 2H), 5. [10] (s, 2H), 7.27-7. [38] (m, [5H).]

31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/33451; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, To an ice-cooled mixture of Compound I (5.0 g) and THF (150 mL) was added NCS (64.2 g), and the mixture was stirred at 55¡ãC for 1 hour. To the reaction mixture was added water, and the mixture was extracted with hexane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give Compound II.

872-32-2 2-Methyl-1-pyrroline 70103, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; Dainippon Sumitomo Pharma Co., Ltd.; HORIUCHI, Yoshihiro; FUJIWARA, Hiroaki; SUDA, Hitoshi; SASAKI, Izumi; IWATA, Mitsutaka; SAWAMURA, Kiyoto; EP2612848; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of amine 8 (23.9 mg, 29. 0 [JMOL)] dissolved in 1 M aqueous solution of NaHCO3 (1 mL) was treated with methoxycarbonylmaleimide (27.03 mg, 17. [4] pmol) at [0 C.] After 5 min, the mixture was diluted with water (1 [ML)] and acetonitrile (2 mL), and then stirred at room temperature for 1 h. The mixture was diluted with CH2Cl2 (50 mL) and washed with brine [(3X10] mL). The organic phase was dried over [NA2SO4,] filtered and concentrated. The oily residue was purified by flash chromatography [(CH2CL2/MEOH] 96: 4) to give maleimide 9 (20.3 mg, 71%) ; Rf 0. 45 [(CH2CL2/MEOH] 96: 4) [;’H-NMR (CDC13/TMS)] : [No.6. ]72 (s, 8 H, CH=CH), 4.94 (d, [1] H, J=3. 4 Hz, [H-1),] 3.95-3. 82 (m, 2 H, H-4, and [OCHHCH2CH2N),] 3. [80No.3. ]45 (m, 22 H, H-2, H-3, H-5, H-6, H-6′, [OCH2CH2CH2S,] SCH2CH2N, and [OCH2CH3),] 2.90-2. 60 (m, 16 H, [OCH2CH2CH2SCH2CH2N),] 1.96-1. 82 (m, 8 H, OCH2CH2CH2S), 1.23 (t, 3 H, J=7.1 Hz, OCH2CH3) ; ES-MS: 1019.49 (M+Na) [+,] 951 (M-OEt) +.

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE; WO2004/802; (2003); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.872-32-2,2-Methyl-1-pyrroline,as a common compound, the synthetic route is as follows.,872-32-2

General procedure: Acyl chloride (1.2 mmol, 1.2 equiv) was added to a solution of 4-dimethylaminopyridine (DMAP) (1.2 mmol, 1.2 equiv) in acetonitrile (1.0 mL) at 0 ¡ãC. The reaction was stirred at room temperature for 15 min. A solution of the 5-methyl-3,4-dihydro-2H-pyrrole (1.0 mmol) in acetonitrile (1.0 mL) was added and the reaction was stirred at room temperature for 3 h. p-Toluenesulfonic acid monohydrate (3.0 mmol, 3.0 equiv) was added at 0 ¡ãC under inert atmosphere. The reaction was then stirred at room temperature for 2 h. Arylhydrazine (1.5 mmol, 1.5 equiv) was added and stirred for an addition 5 min at room temperature. The reaction was then heated to 82 ¡ãC for 20 h. The reaction cools down to room temperature. The residue was then dissolved in ethyl acetate and washed with brine and a saturated aqueous solution of NaHCO3. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude solid, which was purified by column chromatography on silica gel.

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang; Tetrahedron; vol. 68; 3; (2012); p. 813 – 818;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

Triethylamine is added to a mixture of 5-methoxy-3,4-dihydro-2H-pyrrole (73 g, 0.73 mmol) and 3-oxopentanedioic acid diethyl ester (200 g, 0.99 mmol) at room temperature. The resulting solution is stirred for 5 days after which the reaction mixture is filtered to give 39 g (24percent yield) of 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester as a white solid. The NMR spectrum of the title compound is according to theory.1H NMR (CDCl3, 300 MHZ): delta 11.4 (s, 1H), 5.80 (s, 1H), 4.40 (q, 2H), 4.15 (t, 2H), 3.50 (t, 2H), 2.3-2.15 (m, 2H), 1.40 (t, 3H).

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novartis AG; US2009/275606; (2009); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55750-48-6

Using a 40 mL vial, a solution of prop-2-yn-1 -amine (500 mg, 9.08 mmol) in 15 mL of sat. aqueous NaHCO3 was cooled to 0 C with ice bath and then methyl 2,5-dioxo-2,5-dihydro-1 H-pyrrole-1 -carboxylate (1 .27 g, 8.17 mmol) was added. The reaction mixture was then stirred at the same temperature for 4 h and then extracted wtih 50 mL of CH2CI2 three times. The combined organic layers were dried over Na2SO4, concentrated, purified by ISCO (24 g, silica gel) and concentrated to give 1-(prop-2-yn-1-yl)-1H-pyrrole- 2,5-dione (i-3). 1H-NMR (CDCI3, 400 MHz) O 6.76 (s, 2H), 4.29 (d, 2H, J = 2.8 Hz), 2.21(t, 1H, J=2.8 Hz).

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; GRUNEWALD, Jan; JIN, Yunho; OU, Weijia; UNO, Tetsuo; (279 pag.)WO2016/71856; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: To a solution of i-Pr2NH (1.52 g, 2.1 mL, 15 mmol, 1.5 equiv) in anhyd THF (20 mL) was added n-BuLi (6 mL, 15 mmol, 1.5 equiv, 2.5 M in hexane) via a syringe at 0 ¡ãC under a nitrogen atmosphere, and the resulting solution was stirred for 30 min at 0 ¡ãC. Subsequently, 2-methyl-1-pyrroline (1; 0.83 g, 0.95 mL, 10 mmol, 1 equiv) was added via a syringe at 0 ¡ãC and the resulting solution was stirred for 1 h at 0 ¡ãC. Then, a solution of 1-benzyl-2-(bromomethyl)aziridine (2, R = Ph;8 2.25 g, 10 mmol, 1 equiv) in THF (10 mL) was added via a syringe at 0 ¡ãC and the resulting solution was stirred for 17 h at r.t. Afterwards, the reaction mixture was poured into H2O (50 mL) and extracted with Et2O (3 ¡Á 50 mL). Drying (MgSO4), filtration of the drying agent, and evaporation of the solvent in vacuo furnished 3a as an orange oil; yield: 2.12 g (9.3 mmol, 93percent). Because of the high purity of the obtained aziridines 3 (purity >95percent, 1H NMR), these compounds were used as such in the next step.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Dolfen, Jeroen; D?hooghe, Matthias; Synthesis; vol. 49; 10; (2017); p. 2215 – 2222;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem