Category: pyrrolines

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-methyl-1-pyrroline (2.8 g, 33.7 mmol) and the corresponding cyclic phosphite 2a-2e (30.6 mmol) were stirred in toluene (5 mL) for 4-6 h at room temperature (conversion was checked by TLC or 31P NMR), the mixture was poured into 30 mL water, slowly acidified to pH 3 with 11 N HCl then quickly extracted with tert-butyl methyl ether (TBME) (3 .x. 20 mL). The aqueous phase was basified to pH 9-10 with NaOH pellets then extracted with CH2Cl2 (4 .x. 20 mL). The combined organic phases were dried over MgSO4, filtered and roto-evaporated to give the crude aminophosphonates 3a-3e as white powders which were then purified by SiO2 column chromatography with eluent CH2Cl2/EtOH 8/1., 872-32-2

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gosset, Gae?lle; Cle?ment, Jean-Louis; Culcasi, Marcel; Rockenbauer, Antal; Pietri, Sylvia; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2218 – 2230;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate (2 g, 9.84 mmol) was taken in THF (16 mL) and water (6 mL), to it OsO4 (25 mg, 0.098 mmol), NMO (1.6 g, 13 mmol) were added. The reaction mixture was stirred at room temperature for 15 h. The reaction mixture was concentrated and the crude was partitioned between EtOAc and water. Layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over Na2SO4, concentrated and purified by column chromatography to yield the pure benzyl 3,4-dihydroxypyrrolidine-1-carboxylate (2.2 g, 95percent).

31970-04-4, 31970-04-4 Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate 643471, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION; US2012/295874; (2012); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5264-35-7,5-Methoxy-3,4-dihydro-2H-pyrrole,as a common compound, the synthetic route is as follows.

5-methoxy-3,4-dihydro-2H-pyrrole (0.3 mL) was added to the solution of 5-propyl-8- [(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole tetraTFA salt (110 mg, 138 mg) in methanol (1 mL) at room temperature. The EPO mixture was stirred at room temperature overnight and purified by preparative HPLC (10-70percent CH3CN) to afford the title compound as its TFA salt (31mg). MS (M+l): 407.1. 1H NMR (400 MHz, CD3OD) delta ppm 0.91 (t, J=7.42 Hz, 3 H), 0.99 (d, J=6.44 Hz, 3 H), 1.06 – 1.28 (m, 2 H), 1.55 – 1.89 (m, 5 H), 2.14 – 2.39 (m, 2 H), 2.89 (s, 1 H), 3.00 – 3.21 (m, 4 H), 3.67 – 3.92 (m, 3 H), 3.94 – 4.06 (m, 2 H), 4.08 – 4.18 (m, 2 H), 4.60 (s, 1 H), 4.79 – 4.89 (m, 2 H), 7.17 – 7.27 (m, 1 H), 7.41 – 7.60 (m, 2 H)., 5264-35-7

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca AB; WO2006/101434; (2006); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5264-35-7, Step A: Preparation of 3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1) To a stirred solution of 3,4-dihydro-5-methoxy-2H-pyrrole (5.00 g, 50.43 mmol) in ethanol (30 mL) was added ammonium chloride (2.68 g, 50.43 mmol). The reaction mixture was stirred at room temperature for 24 h. The organic layer was then concentrated under reduced pressure to afford the title product as a white solid (6.0 g), which was used without further purification in the next step.

5264-35-7 5-Methoxy-3,4-dihydro-2H-pyrrole 353443, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; US2010/99561; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6,55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

30 mg (30 mumol) of Intermediate 89 were taken up in 2 ml of 1,4-dioxane and admixed with 4 ml of saturated sodium hydrogencarbonate solution and then with 7.5 mg (50 mumol) of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. The reaction mixture was stirred at RT for 1 h and then concentrated under reduced pressure. The remaining residue was purified by means of preparative HPLC. After lyophilization, 24 mg (74% of theory) of the title compound were obtained. [1937] HPLC (Method 5): Rt=2.2 min; [1938] LC-MS (Method 1): Rt=1.01 min; MS (ESIpos): m/z=1006 (M+H)+.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lerchen, Hans-Georg; Hammer, Stefanie; Harrenga, Axel; Kopitz, Charlotte Christine; Nising, Carl Friedrich; Sommer, Anette; Stelte-Luowig, Beatrix; Mahlert, Christoph; Schuhmacher, Joachim; Golfier, Sven; Greven, Simone; Bruder, Sandra; US2015/23989; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the olefin (10. 0g, 49 MMOL) in CH2CI2 (250 ML, 0.2M) was added MCPBA (22g, 2.0 eq. ). The reaction was stirred for 48h and 200ML of saturated sodium thiosulfate was added. After 20 min, the layers were separated and the organic layer was washed with 2N NAOH (2 x 100ML). The organic layer was dried MgS04, filtered and concentrated to provide the title compound as an oil (10.79 G, 99%): 1H NMR (300 MHz, CDCI3) 8 7.35, 5.13, 3.93-3. 84,3. 71,3. 43-3.38 ; IR (LIQ.) 2209. (w), 2068 (w), 1958 (w), 1706 (s), 1455,1448, 1428 (s), 1397 (s), 1364, 1327 (s), 1214,1206, 1107 (s), 848 (s), 699, cm-1 Anal. CALCD for C12 H13 N 03 : C, 65.74 ; H, 5.98 ; N, 6.39. Found: C, 65.45 ; H, 6.07 ; N, 5.99.

31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/99201; (2004); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

55750-48-6,55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00170] Amine 5 (366 mg. 606 muetaiotaomicron), Hunig’s base (314 mg, 2.43 muetaiotaomicron) and methoxycarbonylmaleimide (104 mg, 667 muetaiotaomicron) were dissolved in dichloroethane (5 mL) and heated at 70 C. After twenty hours, the mixture was concentrated and chromatographed (silica gel, 0 to 10% MeOH in CH2C12) to give maleimide 29 (227 mg, 54%) as a glass. LC/MS gave a single peak with m/z = 684.3 [M+l]+, 1 HNMR (DMSO-d6) delta 8.41 (t,J = 5 Hz, 1H), 7.92 (br s, 1H), 7.74 (d, J = 8 Hz, 1H), 7.26 (br s, 1H), 6.99 (s, 2H), 6.77 (d, J = 2 Hz, 1H), 6.67 (dd, J = 2, 8 Hz, 1H), 3.3.38-3.53 (m, 20H), 3.35 (t, J = 6 Hz,2H), 3.2 (q, J = 6 Hz, 2H), 2.92 (s, 2H), 2.4 (s, 3H), 2.33 (s, 2H), 1.81 (p, J = 6 Hz, 2H), 1.69 (p, J = 6 Hz, 2H), 1.01 (s, 6H).

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; DUKE UNIVERSITY; HAYSTEAD, Timothy, A.J.; HUGHES, Philip, Floyd; (96 pag.)WO2017/184956; (2017); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

31970-04-4, To a stirred solution of compound 1 (15g, 73.81 mmol, 1eq) inDCM (300mL) was added then the resulting mixture was stirred for 48h. TLC analysis indicated formation of a polar spot. The reaction mixture was basified with aqueous NaHC03 and extracted with EtOAc (3x100ml_). The combined organic layer was dried over Na2S04 then concentrated to crude compound. The crude compound was purified by column chromatography (silica gel, 100-200 mesh) using 0-20% EtOAc in petroleum ether as eluent to afford compound 2 (15.2g, 93%) as yellow color liquid.

31970-04-4 Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate 643471, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: 4-Chloro-benzenesulfonyl chloride (6.33 g, 30 mmol) was added to a solution of 4-dimethylaminopyridine (DMAP) (3.67 g, 30 mmol) in anhydrous DMF (25 mL) at 0 ¡ãC. The reaction was stirred at 23¡ã C for 30 minutes. A solution of 2-methyl-l-pyrroline (2.08 g, 25 mmol) in anhydrous DMF (25 mL) was added and the reaction was stirred at the same temperature for 1 hour. Methanesulfonic acid (4.87 mL, 75 mmol) was added to the reaction at 0 ¡ãC. The reaction was then stirred at 23¡ã C for 2 hours. 4-Bromo-2-fluoro-phenyl hydrazine hydrochloride (9.06 g, 35.7 mmol) was added and stirred for an additional hour at 23¡ã C. The reaction was then heated to 85 ¡ãC for 12 hours in a sealed tube. The reaction was then cooled to room temperature and concentrated in vacuo. The resulting residue was dissolved in ethyl acetate and washed with saturated aqueous solution of NaHC03 followed by brine. The combined organic layers were dried over anhydrous Na2S04; filtered and concentrated in vacuo to give a crude product, which was purified by column (0241) chromatography on silica gel eluting with 70:30 Hex: EtOAc to give N-(2-(5-bromo-7-fluoro- 2-methyl-lH-indol-3-yl)ethyl)-4-chlorobenzenesulfonamide (SI) as an off-white solid

The synthetic route of 872-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; WANG, Xiang; BARBOUR, Patrick; (44 pag.)WO2016/176634; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part A: Phenylmethyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate. To a 0 0C solution of phenylmethyl 2,5-dihydro-1H-pyrrole-1-carboxylate (10.30 g, 50.68 mmol) in DCM (250 mL) was added m-CPBA (wet; ca. 75%; 17.49g). The solution was stirred and warmed to room temperature overnight. The solution was diluted with DCM and washed with 2 x 10% aq. NaHCO”3 – 1 N aq. NaOH (1 :1 ). The organic phase was dried over anhydrous Na2SO4, filtered, concentrated in vacuo, and purified by silica gel chromatography (40% EtOAc in hexanes) to give phenylmethyl 6-oxa-3- azabicyclo[3.1.0]hexane-3-carboxylate (7.90 g, 71 % yield) as a light yellow oil., 31970-04-4

31970-04-4 Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate 643471, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem