Category: pyrrolines

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-L-valyl-N-{3-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]propyl}-L-alaninamide The title compound was prepared from Example M9 first by coupling to N-[(benzyloxy)carbonyl]-L-valyl-L-alanine in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protecting group was removed by hydrogenating over 10% palladium on activated carbon at RT under hydrogen standard pressure for 1 hour and then converting the deprotected intermediate to the title compound by coupling to (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine. LC-MS (Method 1): Rt=1.21 min; MS (ESIpos): m/z=777 (M+H)+., 25021-08-3

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; MARX, Leo; JOHANNES, Sarah Anna Liesa; STELTE-LUDWIG, Beatrix; DIETZ, Lisa; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (481 pag.)US2019/77752; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: Dried pressure tube was charged with magnetic stir bar and50 mg of PdSiO2 catalysts (1 mol% with respect to amine). Then,1.0 mL o-xylene was added, followed by the addition of 0.5 mmolof amine and 1 mmol of benzyl alcohol. The pressure tube wasflushed with argon was closed with screw cap. Then it was placedin the preheated aluminum block and reaction was allowed to progressfor 30 h at 150 C. After completion of the reaction, pressuretube was removed from aluminum block and cooled down to roomtemperature. The catalyst was filtered out by ciliate and reactionproducts were analyzed by GC-MS and the corresponding amineswere purified by column chromatography. The yields of selectedamines were determined by GC analysis using n-hexadecane asstandard. For this purpose, after completion of the reaction, nhexadecane(100 mL) as standard was added to the reaction pressuretube and the reaction products were diluted with ethyl acetate followed by filtration using plug of silica and then subjected GCanalysis., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Alshammari, Ahmad S.; Natte, Kishore; Kalevaru, Narayana V.; Bagabas, Abdulaziz; Jagadeesh, Rajenahally V.; Journal of Catalysis; vol. 382; (2020); p. 141 – 149;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,3-dibromomaleimide (0.255 g, 1.0mmol) in tetrahydrofuran (4 ml) N-methylmorpholine (76 mul, 1.1mmol) and methyl chloroformate (85 mul, 1.1mmol) were added at 0 C. When TLC (nhexane:acetone=8:2) showed complete conversion of the starting material(3 h), the reaction mixture was diluted with CH2Cl2, filtered through a pad ofCelite and evaporated. The obtained crude 4 (0.308 g) was reacted, withoutpurification, with t-butyl mercaptan 2g (237 mul, 2.1mmol) according to generalmethod A to give compound 6g (0.150 g). The crude product was used forfurther step without purification.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.

151038-94-7, [4593] 8 mg (7.5 f.tmol) ofN-(3-carboxypropyl)-N-methylL-valyl-N -[ (3R,4S,5S)-3-methoxy-1-{ (2S)-2-[ (1 R,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2S,3E)-1-phenyl-4-( 4-sulphophenyl)but-3-en-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 2.8 mg(8.2 f.tmol) of 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazidetrifluoroacetate, 3.4 mg (9 f.tmol) ofHATU and3.9 fll ofHunig’s base were stirred in 0.77 ml ofDMF at RTfor 20 h. Subsequently, the reaction mixture was purified bymeans of preparative HPLC.[4594] 3 mg (31% of theory) of the title compound wereobtained.[4595] LC-MS (Method 1): R,=0.90 min; MS (ESipos):m/z=1164 (M+Ht

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 2,3-dibromo-N-isobutane-maleimide:Dissolve 200 mg of sodium hydride in 10 mL of N, N-dimethylformamide in an ice-water bath.Dissolve 600mg of 2,3-dibromomaleimide in 10mLN, N-dimethylformamide was added dropwise to sodium hydride,After stirring for 30min, 1-bromo-2-methylpropane was added, and the reaction was heated to 60 C for 1h.Quenched by saturated ammonium chloride after cooling,Ethyl acetate extraction, drying over anhydrous sodium sulfate, concentration, column chromatography403 mg of product was obtained., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Wang Ying; Wang Ruifang; Wang Pengfei; Liu Yanwei; Wei Xiaofang; Liu Jianjun; Li Zhiyi; Hu Xiaoxiao; (24 pag.)CN110551054; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4 (8.53 g, 0.055 mol) was refluxed for 1 hour in thionyl chloride (40 mL).Evaporate excess thionyl chloride,The intermediate acid chloride was obtained as a dark oil.20 degrees,The oil was dissolved in dichloromethane (30 mL).And slowly added dropwise to a solution of amino compound 3 (11.66 g, 0.05 mol) and triethylamine (10.12 g, 0.1 mol) in dichloromethane (70 ml).Stirring was continued for 2 hours.The reaction solution was washed with dilute hydrochloric acid and 5% aqueous sodium hydroxide solution, respectively.The organic phase is concentrated and dried,The resulting residue was dissolved in isopropanol (60 ml) at 50 C.36% hydrochloric acid (25.35 g, 0.25 mol) was added dropwise, and stirring was continued for 2 hours.Slowly add water (100 ml),Cool to 5 degrees to precipitate a light solid.filter,The filter cake is washed with cold water.The filter cake was dried to obtain 12.57 g of product 5,The yield was 80%., 25021-08-3

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Zhenlaimai New Materials Technology Co., Ltd.; Wang Ruidong; Xiao Juan; (11 pag.)CN108892631; (2018); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1)., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

17057-04-4, The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

69778-83-2, 4-Methoxy-1H-pyrrol-2(5H)-one is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

69778-83-2, Preparation of 5-bromo-3-methoxypyrrole-2-carboxaldehyde B To a solution of phosphoryl bromide (220 mol percent, 5.58 g) in dry dichloromethane (20 mL) was added DMF (220 mol percent, 1.4 mL) dropwise over 2 minutes. The resulting reaction mixture was stirred at room temperature for 30 min and concentrated in vacuo to provide the Vilsmeyer complex as a white solid. After drying in vacuo for 1 h, the white solid was suspended in dry dichloromethane (20 mL) and cooled to 0¡ã C. A solution of 4-methoxy-3-pyrrolin-2-one (A) (1 g, 8.84 mmol) in dichloromethane (10 mL) was added dropwise and the resulting reaction mixture was stirred at 0¡ã C. for 30 min, then at room temperature for 20 h. The mixture was poured onto ice (75 mL), treated with aqueous NaOH 4N (50 mL), diluted with EtOAc (100 mL), and stirred for 15 min. The layers were separated, and the aqueous layer was extracted with EtOAc (3*60 mL). The combined organic layers were washed with brine (3*200 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford a crude residue that was purified using flash column chromatography over silica gel with a gradient elution of 0-20percent EtOAC/Hexanes to provide Compound B as a white solid. NMR 1H (300 MHz, CDCl3): delta (ppm) 3.95 (s, 3H); 5.90 (s, 1H); 9.30 (s, 1H), 9.92-10.34 (bs, 1H). m/z: 205.1 [M+1]

As the paragraph descriping shows that 69778-83-2 is playing an increasingly important role.

Reference£º
Patent; Dairi, Kenza; Lavallee, Jean-Francois; Doyle, Terrence W.; US2005/267073; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dibromomaleimide 1a, 2.0 g (7.84 mmol), was dissolved in 15 mL of anhydrous DMF, and 0.9 mL (9.51 mmol) of 4-fluoroaniline and 2 mL (11.5 mmol) of DIPEA were added. The mixture was stirred for 24 h at 50C and poured into a mixture of water and ethyl acetate. The organic layer was separated, washed with dilute aqueous HCl, and evaporated under reduced pressure, and the residue was purified by column chromatography using petroleum ether-ethyl acetate (5 : 1) as eluent.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Panov; Simonov, A. Yu.; Korolev; Russian Journal of Organic Chemistry; vol. 55; 12; (2019); p. 1847 – 1852; Zh. Org. Khim.; vol. 55; 12; (2019); p. 1850 – 1856,7;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem