Category: pyrrolines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oic acid Tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (100 mg, 201 mumol) was initially charged in 1.0 ml of DMF and (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid (46.8 mg, 301 mumol), 1-hydroxy-1H-benzotriazole hydrate (76.9 mg, 502 mumol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (77.0 mg, 402 mumol) were added. The reaction mixture was stirred overnight at RT and then ethyl acetate was added. The organic phase was washed twice with 5% citric acid solution, with sat. sodium hydrogen carbonate solution and then with sat. sodium chloride solution. The organic phase was dried over magnesium sulfate. The solvents were evaporated under vacuum and the residue purified by prep. RP-HPLC (column: Reprosil 125*30; 10mu, flow: 50 mL/min, MeCN/water/0.1% TFA). The solvents were evaporated under vacuum and the residue dried under high vacuum. This gave 19.1 mg (13% of theory) of the compound tert-Butyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oate. LC-MS (Method 1): Rt=0.87 min; MS (ESIpos): m/z=635 [M+H]+, 25021-08-3

The synthetic route of 25021-08-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; WITTROCK, Sven; BERNDT, Sandra; GRITZAN, Uwe; FITTING, Jenny; STELTE-LUDWIG, Beatrix; JONES, Patrick; MAHLERT, Christoph; VOTSMEIER, Christian; SCHOeNFELD, Dorian; TRAUTWEIN, Mark; WEBER, Ernst; PAWLOWSKI, Nikolaus; GREVEN, Simone; GLUeCK, Julian Marius; HAMMER, Stefanie; DIETZ, Lisa; MAeRSCH, Stephan; (357 pag.)US2020/138970; (2020); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69778-83-2,4-Methoxy-1H-pyrrol-2(5H)-one,as a common compound, the synthetic route is as follows.,69778-83-2

EXAMPLE 1 Compound (IV) To a solution of 2-formyl-5-undecylpyrrole (4 g; 16.03 mmols) and 4-methoxy-3-pyrrolin-2-one (3.63 g; 32.06 mmols) in DMSO (53 ml) 2N sodium hydroxyde (45 ml) is added under nitrogen atmosphere and the mixture is stirred at 60¡ã C. for 8 hours. After dilution with water (200 ml) the yellow suspension is extracted with dichloromethane (600 ml). The organic phase is shaken with water and brine, anhydrified over anhydrous sodium sulphate and evaporated to dryness. The crude material is taken up in hexane and filtered to give 4-methoxy-5-(5-undecyl-1H-pyrrol-2-yl-methylene)-1,5-dihydro-pyrrol-2-one (4.86 g; 14.11 mmols) as a yellow crystalline solid. Yield: 88percent. 1 NMR (400 mhz, CDCl3), ppm: 0.87 (3H, m), 1.2-1.5 (16H, m), 1.72 (2H, m), 2.73 (2H, m), 3.89 (3H, s), 5.08 (1H, d, J=1.7 Hz), 5.97 (1H, dd, J=2.4 and 3.2 Hz), 6.31 (1H, s), 6.36 (1H, t, J=3.2 Hz), 10.25 (1H, bs), 10.74 (1H, bs).

As the paragraph descriping shows that 69778-83-2 is playing an increasingly important role.

Reference£º
Patent; Pharmacia & Upjohn S.p.A.; US6071947; (2000); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

6913-92-4, Cycloaddition of the nitrone 7 on benzyl-3-pyrroline 2 in order to obtain the heterobicycle 8: The nitrone 7 (300 mg, 2.29 mmol) and benzyl-3-pyrroline 2 (0.8 ml, 4.20 mmol) are dissolved in toluene (3 ml) and stirred for 1 h at 80 C. with microwave irradiation. TLC (AcOEt/petroleum ether 1/3) shows total transformation of the nitrone. The solvent is then evaporated before purification of the cycloadduct 8 (390 ring, 58%) on a silica column (eluent: AcOEt/toluene 1/4) which removes the more polar compounds also formed. Aspect: colorless oil. Rf=0.4 (EtOAc/toluene 1/4). 1H NMR (500 MHz, CDCl3): delta 7.35-7.2 (m, 5H, H-Ar), 4.60 (dd, 1H, 3J=4.9 Hz, J=7.4 Hz, H-4), 4.20 (q, 2H, 3J=7.1 Hz, H-8, H-8?), 3.7 (d, 1H, 2J=13.2 Hz, H-11), 3.58 (d, 1H, 2J=13.2 Hz, H-11?), 3.24 (q, 1H, 3J=7.1 Hz, H-3), 3.16 (br s, 1H, H-6), 3.00 (d, 1H, 3J=11 Hz, H-5), 2.94 (d, 1H, 3J=9.8 Hz, H-2), 2.78 (s, 3H, NCH3), 2.28 (br s, 1H, H-2?), 2.19 (br s, 1H, H-5?), 1.27 (t, 3H, 3J=7.1 Hz, H-9) ppm. 13C NMR (126 MHz, CDCl3): delta 170.03 (C-7), 138.58, 128.73, 128.41, 127.17 (C-Ar), 81.03 (C-4), 75.48 (C-6), 61.26 (C-8), 59.08 (C-11), 58.77 (C-5), 56.79 (C-2), 52.54 (C-3), 43.85 (NCH3), 14.24 (C-9) ppm. HRMS ESI: m/z calcul. for C16H23N2O3 [M+H]+: 291.1703. found: 291.1702.

The synthetic route of 6913-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Praly, Jean-Pierre; Aouadi, Kaiss; Cecioni, Samy; Denoroy, Luc; Parrot, Sandrine; US2015/175537; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-beta-alanine The title compound was prepared from commercially available (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid by coupling with tert-Butyl beta-alaninate hydrochloride (1:1) in the presence of EDCI/HOBt and N,N-diisopropylethylamine and subsequent deprotection with trifluoroacetic acid. LC-MS (Method 1): Rt=0.32 min; MS (ESIpos): m/z=227 (M+H)+., 25021-08-3

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; WITTROCK, Sven; BERNDT, Sandra; GRITZAN, Uwe; FITTING, Jenny; STELTE-LUDWIG, Beatrix; JONES, Patrick; MAHLERT, Christoph; VOTSMEIER, Christian; SCHOeNFELD, Dorian; TRAUTWEIN, Mark; WEBER, Ernst; PAWLOWSKI, Nikolaus; GREVEN, Simone; GLUeCK, Julian Marius; HAMMER, Stefanie; DIETZ, Lisa; MAeRSCH, Stephan; (357 pag.)US2020/138970; (2020); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of analogue 2 was undertaken following the procedure of Baker et al.2 Purified amylin-(1-8) (9) (10.0 mg, 12.4 x 10-3 mmol) was dissolved in a deoxygenated mixture of acetonitrile (12.0 mL) and 250 mM potassium phosphate buffer (24.0 mL, pH 7) and was further deoxygenated for 30 min (argon). 2,3-Dibromomaleimide (3.46 mg, 13.59 x 10-3 mmol) was then added and the resulting yellow mixture was stirred at room temperature for 30 min under argon during which time all the starting material had disappeared as judged by analytical RP-HPLC (Figure S 5). Crude product 2 was lyophilised and purified by RP-HPLC on a preparative Waters XTerra Prep. C18 column at a flow rate of 10 mL/min, using a linear gradient of 1%B to 36%B over 23 min (ca. 1.5%B per minute). Fractions were lyophilised to give the title compound 2 as a white amorphous solid (1.7 mg, 15%)., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kowalczyk, Renata; Harris, Paul W.R.; Brimble, Margaret A.; Callon, Karen E.; Watson, Maureen; Cornish, Jillian; Bioorganic and Medicinal Chemistry; vol. 20; 8; (2012); p. 2661 – 2668;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

6913-92-4, 1-Benzyl-3-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6913-92-4, Example 2Synthesis of 3-benzyl-6-oxa-3-aza-bicyclo[3.1.0]hexane (1-2) To an ice-cooled solution of 1 -benzyl pyrroline (0.01 mol), 98% H2SO4 (0.012 mol), water (1.5 g), and acetone (10 mL) in a round bottom flask was added 77% m-CPBA (0.013 mol) with stirring, and allowed to react for about 50 h at room temperature. After completion of the reaction (TLC monitor), acetone was evaporated under reduced pressure, and the mixture was neutralized by 1M NaOH, and extracted with toluene (30 mL ¡Á3). The precipitates that appeared were filtered, and the filtrate was repeatedly washed with water (30 mL ¡Á2). After the solvent was evaporated under reduced pressure, pure product was obtained in 77% yield via column chromatography (silica gel, CH2Cl2:EtOAc :MeOH, 7.5: 2.00: 0.5).

As the paragraph descriping shows that 6913-92-4 is playing an increasingly important role.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

541-59-3,541-59-3, Maleimide is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methylchloroformate (4.4 niL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 niL of EtOAc at 0 0C. The suspension was stirred at 0 C for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

As the paragraph descriping shows that 541-59-3 is playing an increasingly important role.

Reference£º
Patent; ENZON PHARMACEUTICALS, INC.; WO2008/34124; (2008); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-59-3,Maleimide,as a common compound, the synthetic route is as follows.,541-59-3

Example 1 Preparation of N-Methoxycarbonylmaleimide STR13 To a 1000 ml 3-neck round bottom flask was added 400 ml of ethyl acetate. The flask was placed in an ice bath and the temperature was allowed to drop to about 0 C. To the cooled flask was sequentially added with stirring 7.76 g of maleimide and 8.8 ml of N-methylmorpholine. Then, through an addition funnel was added to the stirring mixture 6.26 ml of methyl chloroformate at a rate so as not to raise the temperature above 3 C. Through the addition funnel was then added 5 ml of ethyl acetate as washing and the washing was added to the reaction mixture. The reaction mixture was stirred for 30 minutes at between 0-3 C. Thereafter, the reaction mixture was filtered through a Buchner funnel. The flask was washed 2* with 10 ml of ethyl acetate and the washings were also filtered. The resulting precipitate was washed 2*with 10 ml of ethyl acetate. The combined filtrate and washings were extracted with 100 ml of ice cold water, dried (10 g Na2 SO4), and evaporated to dryness under reduced pressure.

As the paragraph descriping shows that 541-59-3 is playing an increasingly important role.

Reference£º
Patent; Hybritech Incorporated; US5091542; (1992); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an oven-dried 250 ml round bottom flask of dibromomaleimide (DBM) (1.001 g, 3.93mmol), dry methanol (25.0 mL) was added. The solution was allowed to stir at 40 C under N2 gas. In another flask, an anhydrous solution of trifluoromethylbenzyl mercaptan (3.18 g, 16.57 mmol), TCEP (0.50 g, 1.24 mmol), and sodium acetate (1.31 g, 15.99 mmol) in dry methanol (25.0 mL) was added in 6.25 mL increments to the flask with DBM every 30 minutes under anhydrous conditions at 40 C. The reaction mixture was stirred for 4 hours. The solvents were removed in vacuo. The crude product was dissolved in dichloromethane to vacuum filtrate product of sodium acetate and solution was dried in vacuo. The crude product was purified via column chromatography and dried in vacuo to yield intermediate product (1) as a yellow powder (0.918 g, 1.92 mmol, 49%). Rf data (9:1DCM/hexanes) 0.32; 1H NMR (400 MHz CDCl3) delta data 7.63 (4H, d, CH), 7.56 (4H, d, CH), 4.49 (4H, s, CH); 13CNMR (500 MHz CDCl3) delta data 165.7, 140.7, 136.5, 129.2, 129.2, 129.2, 129.2, 125.7, 35.4; HRMS calcd forC20H12F6NO2S2 (M-) 476.0219, found: 476.0214.

1122-10-7, 1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Letter; Hidalgo, Francisco J.; Lorentz, Nathan A. P.; Luu, Tintin B.; Tran, Jonathan D.; Wickremasinghe, Praveen D.; Martini, Olnita; Iovine, Peter M.; Schellinger, Joan G.; Letters in Organic Chemistry; vol. 17; 2; (2020); p. 85 – 89;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: To the solution of dibromomaleimide 1a orN-methyldibromomaleimide 1b (1 mmol) in THF (20 ml)was added solution of the thiophenol (2.2 mmol) and triethylamine(2.2 mmol) in one portion. The resulting solutionwas stirred at room temperature for 1 h, then evaporated invacuo and the residue was redissolved in ethyl acetate-water(20 + 20 ml) mixture. The organic layer was separated,washed with aq. NaHCO3, dried over anhydrous Na2SO4and evaporated. The residue was purified by flash chromatography(ethyl acetate: petroleum ether 3:1)., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Panov, Alexey A.; Lavrenov, Sergey N.; Simonov, Alexander Y.; Mirchink, Elena P.; Isakova, Elena B.; Trenin, Alexey S.; Journal of Antibiotics; vol. 72; 2; (2019); p. 122 – 124;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem