Heterocyclic Building Blocks-Pyrrolines

5264-35-7, In an article, published in an article,authors is Bubenyak, Mate, once mentioned the application of 5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole,molecular formula is C5H9NO, is a conventional compound. this article was the specific content is as follows.

Synthesis of bioisosteric 5-sulfa-rutaecarpine derivatives

Rutaecarpine (Evodia rutaecarpa) derivatives were synthesized by bioisosteric replacements of the quinazolone moiety of the pentacyclic system with benzothiadiazine 1,1-dioxide. Syntheses were performed efficiently by formation of phenylhydrazones via active methylene group transformations of pyrrolo-and pyrido[1,2-b]1,2,4-benzothiadiazine 5,5-dioxides, and subsequent Fischer-indolization. Preliminary testing of compound 3 showed cytotoxic activity against HeLa cells and apoptosis inducing effect. ARKAT-USA, Inc.

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25021-08-3, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 25021-08-3

For PVC heat stabilizer and its synthetic method (by machine translation)

The present invention provides a novel metal-soap heat stabilizer, the structure comprises a maleimide group, substituted amide group, […] group and metal ion, can be used as the heat stabilizer PVC processing process. Compared with the existing heat stabilizer, its advantage lies in a plurality of functional groups in the synthesis of the same molecule, can better coordination function; in the molecule there is a plurality of ether groups and amide, complex processing can be rapidly produced in the process of a Lewis acid such as zinc chloride, significantly reduce the products in the processing of the zinc burning phenomenon, and has better long-term thermal stability. The compounds of novel structure, the synthetic process route is comparatively simple, rich source of raw materials, product is non-toxic, environmental protection, with the traditional calcium-zinc stabilizer control, has more excellent initial and long-term thermal stability, and there is little consumption, good compatibility with the polymer, can be used as a traditional calcium zinc heat stabilizer upgrading products. Its zinc, lime soap can be used as the main stabilizer, the stabilizer in the addition amount is 1 – 40%. (by machine translation)

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1122-10-7, In an article, published in an article,authors is Castaneda, Lourdes, once mentioned the application of 1122-10-7, Name is 3,4-Dibromo-1H-pyrrole-2,5-dione,molecular formula is C4HBr2NO2, is a conventional compound. this article was the specific content is as follows.

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation

In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody-drug conjugate bearing a thiomaleamic acid linker. This linker is stable at physiological pH and temperature, but quantitatively cleaves at lysosomal pH to release the drug payload.

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17057-04-4, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.17057-04-4, name is 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid. A new synthetic method of this compound is introduced below.

General procedure: An oven-dried flask was cooled under a stream of nitrogen and charged with azomethine N-oxide 1 (5 mmol), maleimide 2 (5 mmol) and sodium dried toluene (25 mL). The flask was equipped with a reflux condenser and the mixture was refluxed for 6 hrs (Scheme 3) until the substrates were consumed as judged by TLC. On completion the reaction mixture was concentrated and the precipitated compound was filtered. The crude product consists of a mixture of cis and trans isomers which was subjected to column chromatography over silica gel (100-200 mesh) using hexane: ethyl acetate (9:1) mixture as eluent., 17057-04-4

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 17057-04-4, you can also browse my other articles.

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Article; Kaur, Anjandeep; Singh, Baldev; Jaggi, Amteshwar Singh; Bioorganic and Medicinal Chemistry Letters; vol. 23; 3; (2013); p. 797 – 801;,
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872-32-2, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.872-32-2, name is 2-Methyl-1-pyrroline. A new synthetic method of this compound is introduced below.

872-32-2, 5-Methyl-3,4-dihydro-2H-pyrrole (1.00 g, 12.0 mmol) was dissolved in carbon tetrachloride. To the solution was added NCS (12.85 g, 96 mmol) as a solid and reaction mixture heated to 85 0C and stirred overnight. The mixture was cooled to 0 0C and the precipitate filtered off and the solvent evaporated. The residue was dissolved in methanol and sodium methoxide (3.90 g, 72.2 mmol) was added. The resulting suspension was heated to reflux and stirred for 3 h. The methanol was evaporated and the residue suspended in Et20. The solid was filtered off and the ether evaporated. The residue was dissolved in DCM and 2M HCI was added. The biphasic solution was stirred until no SM remained. The phases were separated and the organic layer was dried over MgSO4 and evaporated to an orange oil. The crude oil was adsorbed onto silica and run on 40 g of silica with EtOAc and Hexanes to afford the title compound as an orange solid (0.2958 g, 1.854 mmol, 15.41 percent yield). 1H NMR (400 MHz, CDCI3): delta ppm 9.54 (br. s., 1 H), 6.80 (s., 1 H), 6.17 (s., 1 H), 3.83 (s, 3 H). MS: m/z 160.0 (M+1 ).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 872-32-2. We look forward to the emergence of more reaction modes in the future.

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Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. An updated downstream synthesis route of 1334177-86-4 as follows., 1334177-86-4

(C) (115,1 laS) -4-((2R, 5R) -3 7-(2, 5-dioxo-2 , 5-dihydro- 1H-pyrrol- 1-yI)-5-isopropyl-2-methyl- 4,7, 35-trioxo- 10, 13, 16, 19,22,25,28,3 1-octaoxa-3, 6, 34-triazaheptatriacontanamido)benzyl 11- hydroxy-8-((5-(((1 15, 1 laS)- 1 1-hydroxy- 1 0-(((4-((1OR, 13R)- lO-isopropyl- 13-met hyl-8, 11- dioxo-2, 5-dioxa-9, 12-diazatetradecanamido) benzyl) oxy)carbonyl)- 7-methoxy-2-methyl-5- oxo-5, 10, 11, 1 la-tetrahydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiazepin-8-yI) oxy)pentyl) oxy) -7- methoxy-2-methyl-5-oxo- 11,1 la-dihydro- 1H-pyrrolo[2, 1-c][1, 4]benzodiaze pine- 10(5H)- carboxylate (106)N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 105 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) in chloroform (5 mL). The reaction was stirred for 1.5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/i0% methanol] gave 106 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 mm; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5).

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid, you can also browse my other articles.

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Patent; CANCER RESEARCH TECHNOLOGY LIMITED; VAN BERKEL, Patricius Henrikus Cornelis; HOWARD, Philip Wilson; WILLIAMS, David G; WO2015/159076; (2015); A1;,
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.31970-04-4, name is Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate. Here is a downstream synthesis route of the compound 31970-04-4. 31970-04-4

Benzyl 6-oxa-3-azabicvclo[3.1.Olhexane-3-carboxylate z To a solution of benzyl 2,5-dihydro-1 H-pyrrole-1-carboxylate (33 g, 163 mmol; 90% from Aldrich) in dichloromethane (540 ml_, 0.3 M solution) was added m-CPBA (44 g, 340 mmol, 77% from Aldrich). After the reaction mixture was stirred at room temperature for 18 h, 500 ml_ of saturated Na2C03 aqueous solution was added and the resulting mixture was stirred at room temperature for 1 h. The organic layer was separated, washed with water and brine, dried over anhydrous Na2S04, filtered, and concentrated in vacuo. The desired product as a yellow oil was obtained in 83% yield (29.5 g) by flash column chromatography. Rf = 0.5 (30% EtOAc in hexanes). 1H NMR (CDCI3, 400 MHz): delta 3.38 (2H, dd, J = 12.8, 6.0 Hz ), 3.68 (2H, d, J = 3.6 Hz), 3.87 (2H, dd, J = 13.2, 19.6), 5.1 1 (2H, s), 7.33( 5H, m). LC/MS (uplc): MH+ 220.0, 0.69 min., 31970-04-4

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 31970-04-4

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Patent; NOVARTIS AG; IRM LLC; BARSANTI, Paul A.; CHAMOIN, Sylvie; DOUMAMPOUOM-METOUL, Lionel; GEIERSTANGER, Bernhard Hubert; GROTZFELD, Robert Martin; GUERRO-LAGASSE, Stephanie; JONES, Darryl Brynley; KARPOV, Alexei; LAFRANCE, Marc; NIETO-OBERHUBER, Cristina; OU, Weijia; PIIZZI, Grazia; WO2014/151030; (2014); A1;,
Pyrroline – Wikipedia
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Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route., 5264-35-7

Triethylamine is added to a mixture of 5-methoxy-3,4-dihydro-2H-pyrrole (73 g, 0.73 mmol) and 3-oxopentanedioic acid diethyl ester (200 g, 0.99 mmol) at room temperature. The resulting solution is stirred for 5 days after which the reaction mixture is filtered to give 39 g (24percent yield) of 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester as a white solid. The NMR spectrum of the title compound is according to theory.1H NMR (CDCl3, 300 MHZ): delta 11.4 (s, 1H), 5.80 (s, 1H), 4.40 (q, 2H), 4.15 (t, 2H), 3.50 (t, 2H), 2.3-2.15 (m, 2H), 1.40 (t, 3H).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 5-Methoxy-3,4-dihydro-2H-pyrrole

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Patent; Novartis AG; US2009/275606; (2009); A1;,
Pyrroline – Wikipedia
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55750-48-6, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. Here is a downstream synthesis route of the compound 55750-48-6

55750-48-6, Step 1: t-Butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate(250 mg, 1.0 mmol) andmethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (156 mg, 1.0 mmol) were combined in saturated aqueous NaHCO3 (10 ml) and stirred for 1.5 h at 0C. The reaction mixture was acidified to pH 2 with hydrochloric acid (2 M) and extracted with EtOAc. The organic phase was washed with brine, dried with MgSO4, and concentrated. The crude was purified by ISCO using 0-4% MeOH/DCM to give t-butyl (2- (2-(2-(2,5 -dioxo-2,5 -dihydro- 1 H-pyrrol- 1 -yl)ethoxy)ethoxy)ethyl)carbamate as a colorless oil. MS m/z 229.2(M+1-Boc). Retention time 0.963 mm. ?H NMR (400 MHz, Chloroform-d) 6 6.71 (s, 2H), 5.04 (bs,1H), 3.74 (t, J = 5.4 Hz, 2H), 3.64 (t, J = 5.4 Hz, 2H), 3.61-3.59 (m, 2H), 3.56-3.54 (m, 2H), 3.50 (t, J =5.2 Hz, 2H), 3.31-3.26(m, 2H), 1.44 (s, 9H).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 55750-48-6

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Patent; NOVARTIS AG; ABRAMS, Tinya; COHEN, Steven; D’ALESSIO, Joseph Anthony; DAMIANO, Jason; DURR, Clemens; GEIERSTANGER, Bernhard Hubert; HU, Qi-Ying; HUBER, Thomas; IMASE, Hidetomo; JIN, Yunho; MENEZES, Daniel; MILLER, Kathy; MOHSENI, Morvarid; OU, Weijia; RENDAHL, Katherine; UNO, Tetsuo; WAN, Yongqin; WANG, Xing; (350 pag.)WO2016/203432; (2016); A1;,
Pyrroline – Wikipedia
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55750-48-6, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. An updated downstream synthesis route of 55750-48-6 as follows.

64 mg (70 mumol) of N-(6-aminohexyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S,2R)-1-(1,2-oxazinan-2-ylcarbonyl)-2-phenylcyclopropyl]amino}-3-oxopropyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide (Intermediate 97) were taken up in 3 ml of 1:1 dioxane/water, then adjusted to pH 9 with 4 ml of saturated sodium hydrogencarbonate solution and subsequently admixed with 16.3 mg (110 mumol) of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. The reaction mixture was stirred at RT for 1 h and then concentrated under reduced pressure. Then another 8 mg (55 mumol) of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate were added, and the reaction mixture was adjusted again to pH 9 and stirred at RT for a further hour. This was followed by concentration and purification of the remaining residue by means of preparative HPLC. At first, 31 mg of an as yet uncyclized intermediate were obtained. 27 mg of this intermediate were taken up again in 2 ml of 1:1 dioxane/water and then admixed with 250 mul of saturated sodium hydrogencarbonate solution. After stirring at RT for 2 hours, the reaction mixture was concentrated and the residue was purified by means of preparative HPLC. After lyophilization, 20 mg (29% of theory) of the title compound were obtained. [1949] HPLC (Method 5): Rt=1.96 min; [1950] LC-MS (Method 1): Rt=0.97 min; MS (ESIpos): m/z=992 (M+H)+, 55750-48-6

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 55750-48-6

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Patent; Lerchen, Hans-Georg; Hammer, Stefanie; Harrenga, Axel; Kopitz, Charlotte Christine; Nising, Carl Friedrich; Sommer, Anette; Stelte-Luowig, Beatrix; Mahlert, Christoph; Schuhmacher, Joachim; Golfier, Sven; Greven, Simone; Bruder, Sandra; US2015/23989; (2015); A1;,
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