Heterocyclic Building Blocks-Pyrrolines

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. An updated downstream synthesis route of 55750-48-6 as follows., 55750-48-6

[ 4313] 30 mg (30 f.tmol) oflntermediate 89 were taken up in2 ml of 1 ,4-dioxane and admixed with 4 ml of saturatedsodium hydrogencarbonate solution and then with 7.5 mg (50f.tmol) of methyl 2,5-dioxo-2,5-dihydro-18-pyrrole-1-carboxylate.The reaction mixture was stirred at RT for 1 handthen concentrated in vacuo. The remaining residue was purifiedby means of preparative HPLC. After lyophilization, 24mg (74% of theory) of the title compound were obtained.[4314] HPLC (Method 5): R,=2.2 min;[4315] LC-MS (Method 1): R,=l.Ol min; MS (ESipos):rnlz=1006 (M+Hr.

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Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
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73286-71-2, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.73286-71-2, name is N-Boc-2-pyrroline, below Introduce a new synthetic route.

To N-Boc pyrroline (480 mg; 2.83 mmol) and chloro oxime 2a (557 mg; 2.93 mmol) in ethyl acetate (15 mL), was added dropwise triethylamine (0.4 mL) in ethyl acetate (15 mL). The reaction mixture was stirred at room temperature for 24 hours. An additional portion of chloro oxime 2a (234 mg; 1.23 mmol) and triethylamine were added. After stirring overnight, the reaction mixture was poured into water (50 mL) and extracted. The organic layer was dried (MgSO4), filtered and evaporated. Chromatography with 30% ethyl acetate/hexanes yielded 3a as a white solid.MS 345 (M+Na).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of N-Boc-2-pyrroline. We look forward to the emergence of more reaction modes in the future.

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Patent; Macielag, Mark J.; Weidner-Wells, Michele A.; Lin, Shu-Chen; US2009/29980; (2009); A1;,
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.73286-71-2, name is N-Boc-2-pyrroline. Here is a downstream synthesis route of the compound 73286-71-2. 73286-71-2

Reference Example 1; tert-Butyl (3aR*,9bR*)-2,3,3a,4,5,5a,9a,9b-octahydro-lH- pyrrolo[3,2-c]quinoline-1-carboxylate; Sodium (1.2 g, 50 mmol) was dissolved in methanol (15 ml), aniline (0.9 g, 10 mmol) was added at room temperature, and the mixture was stirred for 10 min. This mixture was added to a suspension of paraformaldehyde (0.42 g, 14 mmol) in methanol (10 ml), and the mixture was stirred at room temperature for 5 hrs. The reaction mixture was poured into ice water, and the mixture was extracted with diethyl ether. The extract was dried (over anhydrous MgS04), and the solvent was evaporated under reduced pressure. The residue was dissolved in methanol (20 ml), tert-butyl 2,3-dihydro- 1H-pyrrole-1-carboxylate (850 mg, 5 mmol) was added and the mixture was heated under reflux for 18 hrs. The residue was subjected to column chromatography using silica gel (30 g) and eluted with hexane-ethyl acetate (9: 1-4:1, v/v) to give the title compound (180 mg, 12%) as an amorphous form. ?H-NMR (CDC13) 8: 1 . 48 (9H, d, J=6.1 Hz) , 1 . 76-2 . 01 (2H, m), 2.23-2.45 (lH, m), 3.13-3.57 (5H, m), 5.09 (lH, dd, J=47.2,4.0 Hz), 6.54-6.85 (2H, m), 7.10-7.23 (2H, m). LC/MS (ESI) m/z: 275 (MH+).

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 73286-71-2

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Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/105802; (2005); A1;,
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6913-92-4, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.6913-92-4, name is 1-Benzyl-3-pyrroline. A new synthetic method of this compound is introduced below.

Example 16 2-benryl-5-tert butyl-1,2,3,3a-tetrahydrocyclopenta[c]pyrrol-4(6aH)-one. To a solution of 3,3-dimethyl-1-butyne (29 mg, 0.34 mmol) in 1,2-dichloroethane (1ml) cooled at 0C was added CO2(CO)8 (118 mg, 0.34 mmol) and the mixture was stirred 15 min at 0C and 40 minutes at room temperature. A solution of 1-benzyl-3-pyrroline (50 mg, 0.31 mmol) in 1,2-dichloroethane (1 ml) and dimethylsulfoxide (72 mul, 1.01 mmol) were added and the mixture was heated at 83C for 20 hours. The reaction mixture was filtered through celite and washed with CH2Cl2. The filtrate was concentrated and the crude was purified by flash chromatography: silica gel, dichloromethane, to afforded the product (11 mg, 13%) as yellow oil. 1H NMR (400 MHz, CDCl3): delta (ppm) 7.29-7.17 (m, 5H), 7.08 (d, J=3Hz, 1H), 3.59-3.47 (AB system, 2H), 3.17 (m, 1H), 3.04 (d, J=9Hz, 1H), 2.72 (m, 1H), 2.68 (d, J=9Hz, 1H), 2.35 (t, J=9Hz, 1H), 2.30 (t, J=9Hz, 1H), 1.20 (s, 9H). 13C NMR (75 MHz, CDCl3) delta (ppm) 209.28, 156.44, 154.52, 128.27, 128.19, 126.88, 58.69, 58.78, 56.15, 50.23, 42.00, 31.72, 28.33,. MS (El+) m/z: 269.17 (M+).

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Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; EP1849772; (2007); A1;,
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One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level. 55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate, introduce a new downstream synthesis route., 55750-48-6

A solution of amine 6 (17.8 mg, 0.04 mmol) in 1 M aqueous solution of NaHC03 (1 mL) was treated with methoxycarbonylmaleimide (37.94 mg, 0.24 mmol) at 0 [C.] After 5 min, the mixture was diluted with water [(1] mL) and acetonitrile (2 [ML),] and then stirred at room temperature for 4 h. After adding [CH2C12] (50 [ML),] the organic layer was separated and washed with brine [(3X10] mL). The organic layer was then dried [(NA2SO4),] filtered, and concentrated. The oily residue was purified by flash chromatography (CH2Cl2/MeOH 95: 5) to give maleimide 7 (23.2 mg, 76%); Rf 0. 42 [(CH2CI2/MEOH] 95: 5) [; IH-NMR (CDCL3/TMS)] : [No.6. ]70 (s, 2 H, CH=CH), 6.69 (s, 4 H, CH=CH), 6.68 (s, 2 H, CH=CH), 4.98 (d, [1] H, [J=3.] 4 Hz, H-1), 3.95-3. 82 (m, 2 H, H-4, and [OCHHCH2CH2N),] 3. [80No.3. ] 35 (m, 22 H, H-2, H-3, H-5, H-6, H-6′, [OCH2CH2CH2N,] [OCH2CH2CH2N,] and [OCH2CH3),] 1.96-1. 78 (m, 8 H, [OCH2CH2CH2N),] 1.25 (t, 3 H, J=7.1 Hz, [OCH2CH3)] ; ES-MS: 779.28 (M+Na) [+,] 401.29 (M+2Na) [2+.]

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 55750-48-6. We look forward to the emergence of more reaction modes in the future.

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Patent; UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE; WO2004/802; (2003); A2;,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.134272-64-3, name is N-(2-Aminoethyl)maleimide Hydrochloride. An updated downstream synthesis route of 134272-64-3 as follows., 134272-64-3

To a solution of NHS ester, 7a (5 mg, 4.82 muetaiotaomicron) and l-(2-aminoethyl)-lH- pyrrole-2,5-dione hydrochloride (1.7 mg, 9.64 muiotaetaomicron) in anhydrous dichloromethane (200 mu) was added DIPEA (1.512 mu, 8.68 muiotaetaomicron) under nitrogen. The mixture was stirred at room temperature for 4 hours and then concentrated in vacuo. The resulting residue was purified by RP-HPLC (CI 8, CH3CN / H20). Fractions containing desired product were frozen and lyophilized to give maleimide, compound D7 (3.5 mg, 68% yield). LCMS = 4.61 min (15 min method). MS (m z): 1062.8 (M + 1)+.

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Patent; IMMUNOGEN, INC.; MACROGENICS, INC.; HICKS, Stuart William; YODER, Nicholas C.; BARAT, Bhaswati; BONVINI, Ezio; DIEDRICH, Gundo; JOHNSON, Leslie S.; LOO, Deryk; SCRIBNER, Juniper A.; (260 pag.)WO2018/119196; (2018); A1;,
Pyrroline – Wikipedia
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.2973-17-3, name is 1-Allyl-1H-pyrrole-2,5-dione. An updated downstream synthesis route of 2973-17-3 as follows., 2973-17-3

Synthesis Example f-III-4 Synthesis of Silicone Compound: 1 = 1, m = n = 0, X1 = X3 = Substituent A-6 in the Chemical Structure 1 Drip 3.95 parts of the compound f-II: N-aryl maleimide, 10 parts of toluene, and 0.055 parts of xylene solution of 2 % by weight platinum / 1,3-divinyl-1,1,3,3-tetramethyl disiloxane complex (manufactured by Sigma-Aldrich Co.) to a solution of 3.0 parts of silicone compound: (1,1,3,3,5,5-hexamethyl trisiloxane (manufactured by Sigma-Aldrich Co) and 3.0 parts of toluene in about 60 minutes while stirring at a room temperature followed by reaction under the same condition one night. Thereafter, distill away the solvent with a reduced pressure, conduct stripping treatment for two hours with a reduced pressure of 10 mmHg at 40 C and confirm disappearance of absorption (2155 cm-1 of Si-H in infra-red absorption spectrum to obtain 4.85 parts of the target silicone compound f-M4. The infra-red absorption spectrum graph is shown as Fig. 8D., 2973-17-3

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Patent; Ricoh Company, Ltd.; EP2520579; (2012); A2;,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.69778-83-2, name is 4-Methoxy-1H-pyrrol-2(5H)-one. An updated downstream synthesis route of 69778-83-2 as follows., 69778-83-2

A. A mixture of 4-methoxy-3-pyrrolin-2-one (3 g), 1-octanol (7.4 ml) and methanesulfonic acid (0.2 g) were heated at 100¡ã C. for 2 hours under reduced pressure (40 mbars). The product was chromatographed on silica gel, eluding with 2percent methanol in methylene chloride, to give 4-octyloxy-3-pyrrolin-2-one.

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Patent; Researche Syntex France, S.A.; US4997846; (1991); A;,
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An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.1122-10-7, name is 3,4-Dibromo-1H-pyrrole-2,5-dione. Here is a downstream synthesis route of the compound 1122-10-7. 1122-10-7

Ac-Arg-Arg-Arg-Arg-Cys-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys-Arg-Arg-Arg-Arg-NH2 (2 mg) was dissolved in Dulbecco’s phosphate buffered saline (5 mL, without Ca, Mg) and acetonitrile (5 mL). 3,4-dibromomaleimide (0.2 mg, 1 eq.) was added to the solution, and the mixture was stirred for 1 h at room temperature. To the resulting mixture was added H2O (10 mL) and the solution was filtered and applied to the preparative HPLC, and linear density gradient elution (60 min) was then performed with eluents A/B: 75:25-65:35 using eluent A: 0.1% TFA in water and eluent B: 0.1% TFA-containing acetonitrile on preparative HPLC using YMC-Actus Triart Prep C8-S S-10mum 20 nm column (30 ¡Á 250 mm); flow rate: 15 mL/min. The fractions containing the product were collected and lyophilized to give 1.6 mg of peptide 15 as a yellow powder; mass spectrum: (M + H)+ 2655.54 (calcd 2655.38). Elution time on RP-HPLC: 8.05 min. Elution conditions: YMC Triart C8 column (4.6 ¡Á 100 mm), linear density gradient elution with eluents A/B = 80/20-30/70 (25 min), using 0.1% TFA in water as eluent A and 0.1% TFA-containing acetonitrile as eluent B; flow rate: 1 mL/min., 1122-10-7

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1122-10-7

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Article; Niida, Ayumu; Sasaki, Shigekazu; Yonemori, Kazuko; Sameshima, Tomoya; Yaguchi, Masahiro; Asami, Taiji; Sakamoto, Kotaro; Kamaura, Masahiro; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2757 – 2761;,
Pyrroline – Wikipedia
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25021-08-3, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.25021-08-3, name is 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid. A new synthetic method of this compound is introduced below.

tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (100 mg, 201 mumol) was initially charged in 1.0 ml of DMF, and (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid (46.8 mg, 301 mumol), 1-hydroxy-1H-benzotriazole hydrate (76.9 mg, 502 mumol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (77.0 mg, 402 mumol) were added. The reaction mixture was stirred at RT overnight, and ethyl acetate was then added. The organic phase was washed twice with 5% citric acid solution, with saturated sodium hydrogencarbonate solution and once with saturated sodium chloride solution. The organic phase was dried over magnesium sulphate. The solvents were evaporated under reduced pressure and the residue was purified by preparative RP-HPLC (column: Reprosil 125*30; 10mu, flow rate: 50 ml/min, MeCN/water/0.1% TFA). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 19.1 mg (13% of theory) of tert-butyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oate. LC-MS (Method 1): Rt=0.87 min; MS (ESIpos): m/z=635 [M+H]+, 25021-08-3

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid. We look forward to the emergence of more reaction modes in the future.

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Patent; Bayer Pharma Aktiengesellschaft; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; MARX, Leo; STELTE-LUDWIG, Beatrix; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (684 pag.)US2018/169256; (2018); A1;,
Pyrroline – Wikipedia
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