Heterocyclic Building Blocks-Pyrrolines

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.31970-04-4, name is Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate. Here is a downstream synthesis route of the compound 31970-04-4. 31970-04-4

(2) Benzyl 2,5-dihydropyrrole-1-carboxylate (25 g) was dissolved in chloroform (125 mL), and mCPBA (39 g) was slowly added with ice cooling. The mixture was stirred at room temperature for 1 day, then diluted with chloroform, and washed with saturated aqueous sodium thiosulfate and saturated aqueous sodium hydrogencarbonate. The organic layer was dried with anhydrous sodium sulfate, then the desiccant was removed by filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate = 8:2-1:99) to obtain benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate (18 g). MS: ESI+ (m/z) 242 (M++Na)

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 31970-04-4

Reference£º
Patent; Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.; EP2003131; (2008); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. An updated downstream synthesis route of 1334177-86-4 as follows.

EDCI.HCI (46 mg, 0.24 mmol) was added to a solution of 145 and Mal-PEG8-acid (130 mg,0.22 mmol) in CHCI3 (10 mL) and stirred at room temperature for 2 hr. LC/MS shows 78%starting material present. A further 2 eq EDCI.HCI was added in portions to push the reaction to completion. The reaction mixture was washed with water (10 mL), dried (Biotage PS) and evaporated to dryness, under reduced pressure, to leave a yellow solid which was purified by prep HPLC to leave the product I as an off-white solid (90 mg, 34%yield). LC/MS (method B): retention time 1.47 mins, (ES+) rnlz 1445.9 [M+ H].

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Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; GREGSON, Stephen John; (207 pag.)WO2018/192944; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole. Here is a downstream synthesis route of the compound 5264-35-7

5264-35-7, Step 1 To a solution of 5-methoxy-3,4-dihydro-2H-pyrrole (1.98 g; 20 mmol) in methanol (20 mL) was slowly add cyanamide (0.882 g; 21 mmol). After 5 minutes, a suspension appeared and the reaction mixture was stirred at room temperature for 8 days. The volatiles were removed under reduced pressure to afford 2.18 g (100percent) of N-(pyrrolidin-2-ylidene)cyanamide as a white solid which was used without further purification. ESI/APCI(+): 110 (M+H). 1H NMR (DMSO-d6) delta 9.50-8.60 (bs, 1H, NH); 3.44 (m, 2H, CH2); 2.66 (m, 2H, CH2); 2.02 (m, 2H, CH2).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Katholieke Universiteit Leuven; Chaltin, Patrick; Christ, Frauke; Debyser, Zeger; De Maeyer, Marc; Marchand, Arnaud; Marchand, Damien; Voet, Arnout; US2013/245049; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: Benzyl cis-3,4-dihvdroxypyrrolidine-l-carboxylate (127)To a solution of compound 126 (3.0 g, 14.76 mmol) in a mixture of acetone and water (32 mL and 6 mL) was added N-methylmorpholine-N- oxide (2.25 g, 19.21 mmol) followed by the addition of osmium tetroxide solution (4percent aqueous, 0.7 mL). The yellow mixture was stirred at ambient temperature overnight. To this solution was added solid sodium metabisulfite (Na2S205, 5.0 g) and the mixture was stirred for 1 h. Acetone was removed from the reaction mixture by evaporation, and the solid obtained was suspended in ethyl acetate and filtered. The solid was dissolved in water, extracted with ethyl acetate and combined with the filtrate. The organic phase was washed with brine, dried (Na2S04) and evaporated to get the crude compound 127. This material was purified by flash chromatography using 1-8percent methanol /dichloromethane as eluent to isolate the pure product as a white solid (3.02 g, 86percent).1H NMR (CDC13, 300MHz) : delta ppm 7.39-7.26 (m, 5H), 5.11 (s, 2H), 4.28-4.20 (m, 2H), 3.65 (dd, J = 11.0, 5.5 Hz, 2H), 3.41 (dt, J = 11.0, 4.1 Hz, 2H), 2.61-2.58 (m, 2H). APCI+ = 238., 31970-04-4

As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; ALNYLAM PHARMACEUTICALS, INC.; RAJEEV, Kallanthottathil, G.; MANOHARAN, Muthiah; JAYARAMAN, Muthusamy; MAIER, Martin; JAYAPRAKASH, Narayanannair, K.; BUTLER, David; WO2012/99755; (2012); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5264-35-7

The reaction mixture comprising 1 mmol of 1-[N-(5,5-dimethyl-3,4,5,6-tetrahydropyrimidinium-2-yl)amino]dodecane-12-ammonium ditrifluoroacetate, 1 mmol (1 eq.) of 3,4-dihydro-5-methoxy-2H-pyrrole and 0.5 ml of triethylamine in 10 ml of absolute ethanol is heated under reflux for 20 hours. After cooling down to ambient temperature, the reaction mixture is evaporated to dryness and chromatographed on a silica column (CH2Cl2/CH3OH/NH4OH 85:13:2) in order to produce the product, in the form of an oil, with a yield of 65percent. NMR 1H (CD3OD, 360 MHz), delta (ppm): 1.12 (s, 6H); 1.36 (m, 16H); 1.60 (n, 2H); 1.69 (m, 2H); 2.28 (m, 2H); 2.93 (m, 2H); 3.09 (s, 4H); 3.22 (m, 2H); 3.31 (m, 2H); 3.75 (m, 2H). MS-ES+: [M+H]+: 378; [M+H+TFA]+: 492; [M+2H]++/2: 189.5

As the paragraph descriping shows that 5264-35-7 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2005/176819; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.,55750-48-6

[ 4313] 30 mg (30 f.tmol) oflntermediate 89 were taken up in2 ml of 1 ,4-dioxane and admixed with 4 ml of saturatedsodium hydrogencarbonate solution and then with 7.5 mg (50f.tmol) of methyl 2,5-dioxo-2,5-dihydro-18-pyrrole-1-carboxylate.The reaction mixture was stirred at RT for 1 handthen concentrated in vacuo. The remaining residue was purifiedby means of preparative HPLC. After lyophilization, 24mg (74% of theory) of the title compound were obtained.[4314] HPLC (Method 5): R,=2.2 min;[4315] LC-MS (Method 1): R,=l.Ol min; MS (ESipos):rnlz=1006 (M+Hr.

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 2; Ci5-l-methyl-3 (9Z,12ZVocta^^; Benzyl 3,4-dihvdroxypyrrolidine-l-carboxylate (9): In a 500 mL RBF, the Cbz Pyrroline (15 gs 73.8 mmol) was dissolved in a mixture of 100 mL THF, 60 mL t-BuOH and 40 mL water for addition of the NMO (30.6 ml, 148 mmol) solution followed by the osmium tetraoxide (0.925 ml, 0.074 mmol) solution. Heated in a 70C oil bath. Solution slowly went from yellow to brown. After 2h, cooled to RT and added 50 mL 10percent aqueous NaHS03. Concentrated and partitioned between 100 mL brine and 100 mL EtOAc. Separated layers and extracted with 100 mL EtOAc. Dried over MgS04, filtered and concentrated to 22.3 g of thick yellow oil. Flash column chromatography from 50-100percent EtOAc in hexane provided compound 9. .H NMR (400 MHz, CDC13) 5 7.35 (m, 5H), 5.22 (s, 2H), 4.42 (m, 4H), 3.63 (m, 2H), 3.42 (m, 3H), 3.20 (m, IH)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; STANTON, Matthew, G.; BEUTNER, Gregory, L.; WO2012/61259; (2012); A2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, General procedure: The maleimide was added to a suspension of P25 in methanol (10%) and acetonitrile (90%). The resulting mixture was then purged with argon for 15 min. The mixture was irradiated with eight 29 cm 15 W Philips Cleo tubes (lambda = 350 nm). Following irradiation the P25 powder was removed via filtration through Celite.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manley, David W.; Buzzetti, Luca; MacKessack-Leitch, Andrew; Walton, John C.; Molecules; vol. 19; 9; (2014); p. 15324 – 15338;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate (2.00 g, 9.80 mmol) in CH2Cl2 (10 mL) was added slowly 3-chloroperbenzoic acid (3.00 g, 14.80 mmol) at 0¡ã C. The reaction mixture was stirred for 13 h at room temperature, then quenched with saturated sodium thiosulfate aqueous solution and extracted with EtOAc. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 6:1 (v/v) PE/EtOAc) to give the title compound as colorless oil (1.75 g, 81.02percent)., 31970-04-4

The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; Zhang, Jiancun; Zhang, Yingjun; Zhang, Weihong; Liu, Bing; Zhang, Jiquan; Liu, Jinlei; Zhang, Lu; US2014/228361; (2014); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7,5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-pyrrolidinone was combined with dimethylsulphate in benzene and refluxed for 3 h. After purification including distillation, the resulting 2-methylimino ester pyrrolidine was combined with excess lithium phenoxide (PhLi) in dry ether at room temperature for 18 h to yield the title compound.

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Benkovic, Stephen J.; Shapiro, Lucy; Wright, Rachel; Stephens, Craig; Kahng, Lyn Sue; Berdis, Anthony; Lee, Irene; US2005/227933; (2005); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem