Heterocyclic Building Blocks-Pyrrolines

17057-04-4, 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Equimolar quantities of maleimide (2) and nitrones (5a-k and 6a-k) were refluxed in toluene (20 ml) and ethyl alcohol (5 ml) for 8-10 h (TLC monitoring using petroleum ether and hexane 1:1) followed by cooling with addition of dry ether. The products (7a-k and 8a-k) were separated out after filtration and recrystallized from toluene and petroleum ether mixture (1:1) to yield cis-isomers (7aa-7ka and 8aa-8ka). The mother liquor on further work up provided trans-isomers which were recrystallized from ethanol and diethyl ether mixture (1:1) (7aa’-7ka’ and 8aa’-8ka’) (Fig. 3).7 These stereoisomers were characterized by their 1H NMR, IR and mass spectra in addition to their melting points and elementary analysis. These stereoisomers have identical IR spectra and elemental analysis but differ in their melting points, 1H NMR and mass spectra.

The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Anand, Preet; Singh, Baldev; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 521 – 530;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.

General procedure: An oven-dried flask was cooled under a stream of nitrogen and charged with azomethine N-oxide 1 (5 mmol), maleimide 2 (5 mmol) and sodium dried toluene (25 mL). The flask was equipped with a reflux condenser and the mixture was refluxed for 6 hrs (Scheme 3) until the substrates were consumed as judged by TLC. On completion the reaction mixture was concentrated and the precipitated compound was filtered. The crude product consists of a mixture of cis and trans isomers which was subjected to column chromatography over silica gel (100-200 mesh) using hexane: ethyl acetate (9:1) mixture as eluent.

The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kaur, Anjandeep; Singh, Baldev; Jaggi, Amteshwar Singh; Bioorganic and Medicinal Chemistry Letters; vol. 23; 3; (2013); p. 797 – 801;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

Reference Example 49 Preparation of Bromo-dansyl-cystamine-maleimide A round bottomed flask was charged with di-dansyl cystamine (48 mg, 0.08 mmol), TCEP (23 mg, 1 eq), and MeOH (10 ml). The reaction mixture was stirred at ambient temperature under argon for 3 hrs. Dibromomaleimide (41 mg, 2 eq) in MeOH (10 ml), was added to the reaction mixture. After 16 hrs, the reaction mixture was concentrated in vacuo. The residue was worked up with DCM and brine. The organic layers were combined, dried (MgSO4) and purified by flash chromatography (silica gel, 0-15% EtOAC-DCM) to yield the desired compound (17 mg, 22%). 1HNMR (CDCl3, 600 MHz), delta8.5 (1H, d J 8.5 Hz aromatic H’s), delta8.2 (2H, m aromatic H’s), delta7.6 (1H, s CONH), delta7.53 (2H, m, aromatic H’s), delta7.15 (1H, d, J=7.4 Hz aromatic H’s), delta5.30 (1H, t, J 5.6 SO2NH), delta3.38 (2H, t, J 6.3 SCH2), delta3.26 (2H, q, J 6.3 NHCH2), delta2.88 (6H, s NCH3); 13CNMR (CDCl3, 150 MHz), delta165.5, 162.9, 152.2, 142.5, 134.5, 130.95, 129.94, 129.92, 129.5, 128.7, 123.3, 119.0, 118.5, 115.4, 45.5, 43.7, 30.5; IR (cm-1) 3295 (br) 1726 (s) MS (ES+) m/z relative intensity: 485 (M, 100); Exact mass calculated for [C18H19N3O4S2Br] requires m/z 484.0000. Found 783.9982.

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; UCL Business Plc; Smith, Mark; Caddick, Stephen; Baker, James; Chudasama, Vijay; (80 pag.)US9295729; (2016); B2;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The carboxylic acid of ligand HL was activated according to a published procedure [16] . Briefly, a solution of HL (48?mg, 0.309?mmol) and DCC (64?mg, 0.309?mmol), dissolved in 1?mL of anhydrous DMF, was sonicated in an ultrasonic bath for 15?min at room temperature. The colorless solution became dark red and a white solid (dicyclohexylurea, DCU) precipitated. Then the precipitate was separated by centrifugation and the supernatant was added very slowly (dropwise for 30?min) to a suspension of (OC-6-44)-diamminedichloridohydroxido(2-hydroxyethanolato)platinum(IV), 2, (100?mg, 0.276?mmol) in 5?mL of anhydrous DMF. The reaction was carried out overnight at room temperature. The mixture was then cooled to -20?C for about 30?min and the precipitate was eliminated by filtration (PTFE filter with a porosity 0.45?mum). The solvent was evaporated by a rotary evaporator and the yellow oil obtained was dissolved in ultrapure water, in order to allow the precipitation of the remained DCU. The yellow solution was filtered (0.45?mum porosity), the water was removed under reduced pressure and the reaction product was precipitated with acetone/diethyl ether and then dried in vacuo. Yield: 83?mg (60%). 1H NMR (D2O) delta: 1.19 (t, 3H, -OCH2CH3, 3J?=?6.95?Hz), 3.43 (q, 2H, -OCH2CH3, 3J?=?6.95?Hz), 4.39 (s, 2H, -OCOCH2), 6.97 (s, 2H, -NCOCH=CH) ppm; 13C NMR (D2O) delta: 16.1 (-OCH2CH3), 40.0 (-OCOCH2), 67.7 (-OCH2CH3), 134.7 (-NCOCH=CH), 172.4 (-NCOCH=CH), 176.3 (-OCOCH2) ppm; 195Pt NMR (D2O) delta: 904?ppm (multiplet of five lines, 1JPt-N?=?197.4?Hz). ESI-MS (positive ion mode): 500?m/z [M?+?H]+, calcd for C8H16Cl2N3O5Pt [M?+?H]+ 500?m/z. Elem. Anal. found: C 19.58; H 3.24; N 8.13%.; calcd. for C8H15Cl2N3O5Pt: C 19.25; H 3.03; N 8.42%.

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various.

Reference£º
Article; Gabano, Elisabetta; Perin, Elena; Bonzani, Diego; Ravera, Mauro; Inorganica Chimica Acta; vol. 488; (2019); p. 195 – 200;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134272-64-3,N-(2-Aminoethyl)maleimide Hydrochloride,as a common compound, the synthetic route is as follows.

Step 2: To a solution of the NHS ester, compound 6a (12.3 mg, 0.011 mmol) and N-(2-aminoethyl)maleimide hydrochloride (2.0 mg, 0.011 mmol) in anhydrous dichloromethane (0.3 mL) was added DIPEA (0.0022 mL, 0.013 mmol). The mixture was stirred at room temperature for 3 hours then it was stripped under reduced pressure. The residue was purified by semi-preparative reverse phase HPLC (CI 8 column, CH3CN/H2O). The fractions that contained pure product were combined, frozen and lyophilized to give the desired maleimide, compound D6 (10 mg, 80% yield). LCMS = 8.3 min (15 min method). MS (m/z): 1181.8 (M + 1)+.

As the paragraph descriping shows that 134272-64-3 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; CHITTENDEN, Thomas; DECKERT, Jutta; HICKS, Stuart, William; LAI, Katharine, C.; PARK, Peter, U.; RUI, Lingyun; TAVARES, Daniel, J.; KOHLI, Neeraj; (274 pag.)WO2018/129029; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound [3-7]a-i (0.01mole) and thionyl chloride (0.01mole) placed in dry benzene (10 ml.) and refluxed for 7 hours. The excess of thionyl chloride and benzene were removed under vacuum after cooling .

25021-08-3 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 319935, apyrrolines compound, is more and more widely used in various.

Reference£º
Article; Samir, Ali H.; Saeed, Ruwaidah S.; Matty, Fadhel S.; Oriental Journal of Chemistry; vol. 34; 1; (2018); p. 286 – 294;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.766-36-9,3-Ethyl-4-methyl-2,5-dihydro-1H-pyrrol-2-one,as a common compound, the synthetic route is as follows.

EXAMPLE 7 trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(3-ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl) -2H-benzo[b]pyran-3-ol 2.4 g (0.08 mol) of 80percent NaH are introduced into a solution of 14.4 g (0.072 mol) of trans-3-bromo-6-cyano-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran -4-ol in 200 ml of DMSO. The mixture is stirred for one hour at 20¡ã C., and 3.6 g (0.12 mol) of 80percent NaH and 15 g (0.12 mol) of 3-ethyl-4-methyl-2-oxo-3-pyrroline are introduced. The reaction mixture is stirred at 40¡ã C. for three hours and then introduced into ice water, and the product is filtered off with suction, dried and chromatographed on a silica gel column using methylene chloride/methanol (95: 5). The product obtained in this way crystallizes from a little ethanol. Crystals of melting point 207¡ã-208¡ã C. C19 H22 N2 O4 (326,41) calc. C 69.92;H 6.80;N 8.58; found C 70.0;H 6.7;N 8.6;

As the paragraph descriping shows that 766-36-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5043344; (1991); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

134272-64-3, N-(2-Aminoethyl)maleimide Hydrochloride is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

NHS ester, compound 5a (8.2 mg, 7.6 muiotaetaomicron) and l-(2-aminoethyl)-lH-pyrrole-2,5- dione hydrochloride (2.2 mg, 0.011 mmol) were dissolved in anhydrous dichloromethane (305 mu) at room temperature. DIPEA (2.66 mu, 0.015mmol) was added and the reaction and was stirred for 3.5 hours. The reaction mixture was concentrated and was purified by RPHPLC (CI 8 column, CH3CN/H20, gradient, 35% to 55%). The desired product fractions were frozen and lyophilized to give maleimide, compound D5 as a solid white powder (5.3 mg, 58% yield). LCMS = 5.11 min (8 min method). MS (m z): 1100.6 (M + 1)+.

134272-64-3 N-(2-Aminoethyl)maleimide Hydrochloride 22118207, apyrrolines compound, is more and more widely used in various.

Reference£º
Patent; IMMUNOGEN, INC.; CHITTENDEN, Thomas; DECKERT, Jutta; HICKS, Stuart, William; LAI, Katharine, C.; PARK, Peter, U.; RUI, Lingyun; TAVARES, Daniel, J.; KOHLI, Neeraj; (274 pag.)WO2018/129029; (2018); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25021-08-3,2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid,as a common compound, the synthetic route is as follows.

Complex (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 3, (56?mg, 0.15?mmol) suspended in 1?mL of DMF was added to a solution of activated ligand HL (0.74?mmol) in 1?mL of DMF (see above). The mixture reacted for 24?h at room temperature. Then, the precipitate was discarded by centrifugation and the solvent removed by means of a rotary evaporator. The residue was dissolved in 200?muL of methanol and precipitated by adding 25?mL of diethyl ether. The crystalline solid is washed with diethyl ether. Yield: 43?mg (56%). 1H NMR (DMSO-d6) delta: 1.91 (s, 3H, CH3), 4.17 (s, 2H, CH2), 6.49 (m, 6H, NH3), 7.09 (s, 2H, CH) ppm; 13C NMR (DMSO-d6) delta: 22.5 (CH3), 47.5 (CH2), 134.8 (CH), 170.4 (NC(O)), 174.4 (OC(O)CH2), 178.0 (OC(O)CH3) ppm; 195Pt NMR (DMSO-d6) delta: 1230?ppm. ESI-MS (positive ion mode): 514?m/z [M?+?H]+, calcd for C8H14Cl2N3O6Pt [M?+?H]+ 514?m/z. Elem. Anal. found: C 18.96; H 2.78; N 7.93%; calcd. for C8H13Cl2N3O6Pt: C 18.72; H 2.55; N 8.19%.

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Article; Gabano, Elisabetta; Perin, Elena; Bonzani, Diego; Ravera, Mauro; Inorganica Chimica Acta; vol. 488; (2019); p. 195 – 200;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

NaOAc (0.42 mL, 5.10 mmol) and thiophenol(0.91 mL, 9.02 mmol) were added to a stirred solutionof 3,4-dibromomaleimide (1.00 g, 3.92 mmol) in MeOH (40 mL). After 30 min of stirring at roomtemperature the mixture was concentrated to dryness and the crude residue waspurified by column chromatography (5% to 20% EtOAc/petrol) to yield the title compound as a yellow solid (0.90mg, 2.87 mmol, 73%). m.p. 108-110 C; nmax(cm-1) 3274, 1774, 1719, 1329,1042, 741; dH (CDCl3, 600MHz) 7.29 (2H, t, J = 7.2 Hz, ArH), 7.25 (4H, t, J = 7.2Hz, ArH), 7.19 (4H, d, J = 7.2 Hz, ArH); dC (CDCl3, 150 MHz) 166.3 (s), 136.7(s), 131.9 (d), 129.1 (d), 128.8 (s), 128.6 (d); HRMS (EI): Mass calculated for C16H10O2NS2312.0153, observed: 312.0153.

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Castaneda, Lourdes; Wright, Zoe V.F.; Marculescu, Cristina; Tran, Trang M.; Chudasama, Vijay; Maruani, Antoine; Hull, Elizabeth A.; Nunes, Joao P.M.; Fitzmaurice, Richard J.; Smith, Mark E.B.; Jones, Lyn H.; Caddick, Stephen; Baker, James R.; Tetrahedron Letters; vol. 54; 27; (2013); p. 3493 – 3495;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem